A5037745385- Reproductive System and Pregnancy
- Salivary Gland Disorders and Functions
- Immunodeficiency and Autoimmune Disorders
- Asthma and respiratory diseases
- Pregnancy and Medication Impact
- T-cell and B-cell Immunology
- Research on Leishmaniasis Studies
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Diabetes and associated disorders
- Gastrointestinal disorders and treatments
- Endometriosis Research and Treatment
- Cancer Cells and Metastasis
- Trypanosoma species research and implications
- Blood disorders and treatments
- Cervical Cancer and HPV Research
- Allergic Rhinitis and Sensitization
- Salivary Gland Tumors Diagnosis and Treatment
- Dermatological and Skeletal Disorders
- Systemic Sclerosis and Related Diseases
- Viral-associated cancers and disorders
- Cancer Immunotherapy and Biomarkers
- Contact Dermatitis and Allergies
- Colorectal and Anal Carcinomas
- Mast cells and histamine
Universidade Nova de Lisboa
2016-2025
Hospital do Espírito Santo
2024
Universidade Lusófona
2024
University of Lisbon
2012-2024
Instituto Politécnico de Lisboa
2024
University of Évora
2024
Weatherford College
2023
Universidade do Porto
2014-2022
ISPA - Instituto Universitário
2022
Nova Medical (United States)
2006-2021
B cells play a role in pregnancy due to their humoral and regulatory activities. To our knowledge, different maturational stages (from transitional memory) of circulating cell subsets have not yet been characterized (cell quantification phenotype identification) healthy pregnant women. Thus, the objective study was characterize these (as well as cells) from late post-partum compare them with non-pregnant In all enrolled women, flow cytometry used according expression IgD CD38 (Bm1-Bm5...
Background: The autoinflammation and phospholipase Cγ2 (PLCγ2)-associated antibody deficiency immune dysregulation (APLAID) syndrome is a rare primary immunodeficiency caused by gain-of-function mutation S707Y in the PLCG2 gene previously described two patients from one family. APLAID presented with early-onset blistering skin lesions, posterior uveitis, inflammatory bowel disease (IBD) recurrent sinopulmonary infections humoral defect, but lacked circulating autoantibodies had no...
BackgroundPredominantly antibody deficiencies (PADs) are the most prevalent primary immunodeficiencies, but their B-cell defects and underlying genetic alterations remain largely unknown.ObjectiveWe investigated patients with PADs for distribution of 41 blood plasma cell (PC) subsets, including subsets defined by expression distinct immunoglobulin heavy chain subclasses.MethodsBlood samples from 139 PADs, 61 common variable immunodeficiency (CVID), 68 selective IgA deficiency (IgAdef), 10...
Adiponectin/leptin ratio, triacylglycerols, and waist-to-hip ratio explained almost half of HOMA-IR variance in the context obesity. This study provides evidence to support adipose tissue dysfunction as a central feature pathophysiology obesity insulin resistance. Early identification individuals at higher risk developing metabolic complications through assessment staging its transient phenotypes can contribute improve therapeutic decision-making.
Endometriosis, a debilitating condition, affects one in ten women of reproductive age. Its pathophysiology remains unclear, though deficiencies immune surveillance are thought to create an environment conducive the evasion ectopic endometrial cells from system. Our research explores immunological impact endometriosis both locally and systemically, emphasizing natural killer (NK) T cell subpopulations. We incorporated 62 female patients who underwent laparoscopic surgery; those, 47 had...
Abstract This study presents a workflow for identifying and characterizing patients with Heart Failure (HF) multimorbidity utilizing data from Electronic Health Records. Multimorbidity, the co-occurrence of two or more chronic conditions, poses significant challenge on healthcare systems. Nonetheless, understanding multimorbidity, including most common disease interactions, risk factors, treatment responses, remains limited, particularly complex heterogeneous conditions like HF. We conducted...
DNA Ligase 4 is critical to nonhomologous end joining, necessary for V(D)J recombination in T and B cell development. deficiency a rare autosomal recessive disorder caused by hypomorphic mutations the gene, that can lead wide range of phenotypes. We describe case causing type T-B-NK+ atypical SCID, highlighting clinical immunologic manifestations. An eight-year-old female, from São Nicolau Island (Cape Verde), presented at our hospital with history recurrent pneumonia suppurative otitis,...
Abstract The present study investigated the operational feasibility of recently developed Salmon Welfare Index Model (SWIM 1.0) designed for Atlantic salmon ( Salmo salar L) in production cages. Ten farms containing spring smolts were visited twice, first between May and June year sea cages, secondly 2-3 months later. On each farm SWIM 1.0 assessments carried out two cages assumed by farmer to represent best worst welfare status. applied indicators (WIs) water temperature, salinity, stocking...
B cells are vital for the normal evolution of pregnancy due to their humoral and possible regulatory activities. Our group others have documented that circulating B-cell subsets undergo changes from late postpartum period. However, underlying mechanisms poorly understood. Therefore, this study examined degree activation in by analyzing levels serum markers healthy pregnant women during third trimester pregnancy, day delivery, period.A prospective including non-pregnant attending routine care...
Objective: Tinnitus is associated with various conditions such as presbycusis, infectious, autoimmune and many other diseases. Our study aims to identify an association between inflammatory markers the presence of tinnitus or hearing loss (HL).Design: Exploratory including a structured interview, complete ENT observation, audiological evaluation.Study Sample: Sixty women 54 men (55 75 years) from Portuguese population, without sensory presbycusis and/or tinnitus.Results: IL10 levels were...
Torque teno virus (TTV) was recently identified as a potential biomarker for the degree of immunosuppression, and potentially predictor rejection infection in solid organ transplant patients. We evaluated TTV viral load kidney (KT) patients during first year post-transplant to examine overall kinetics their relationships with deleterious events, including episodes formation de novo donor-specific antibodies (DSAs). In single-center, prospective observational cohort study, 81 KT were...
Objective Type 1 diabetes (T1D) develops in distinct stages, before and after disease onset. Whether the natural course translates into different immunologic patterns is still uncertain. This study aimed at identifying peripheral immune key time-points, T1D children undergoing remission phase. Methods Children with new-onset healthy age gender-matched controls were recruited a pediatric hospital. Peripheral blood samples evaluated by flow cytometry 3 longitudinal time-points: onset (T1),...
A functional vascular endothelial growth factor (VEGF-A) autocrine loop is crucial for bladder cancer cell survival. We reasoned that treatment with the anti-VEGF antibody bevacizumab may result either in prevention or adaptation to compensate VEGF deprivation.The cytotoxicity of different levels and its effect on gene expression was analyzed human lines.Inhibition proliferation observed at >2.5 mg/ml bevacizumab. Non-muscle-invasive cells expressed high concentrations VEGF-A, were less...
Abstract Sjögren's syndrome (SjS) is characterized by lymphocytic infiltration of exocrine glands, i.e. autoimmune epithelitis. Lymphocytes are central in SjS pathogenesis, with B-cell hyperactivity mediated T-cells. B-cells main targets Epstein-Barr virus (EBV) infection, a frequently-suggested trigger for SjS. We aimed to evaluate how the EBV infection modulates B and T-cell subsets SjS, including as controls Rheumatoid arthritis patients (RA) healthy participants (HC). presented decreased...
Acute pancreatitis (AP) is an increasingly frequent disease in which inflammation plays a crucial role. Fifty patients hospitalized with AP were included and peripheral blood samples analyzed for B T cell subpopulations at the time of hospitalization 48 h after diagnosis. The Bedside Index Severity Pancreatitis (BISAP) length hospital stay also recorded. A healthy control (HC) group 15 outpatients was included. showed higher neutrophil/lymphocyte (N/L) ratios percentages cells than HC group....