A5081900122- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- IgG4-Related and Inflammatory Diseases
- Chronic Lymphocytic Leukemia Research
- Platelet Disorders and Treatments
- Cystic Fibrosis Research Advances
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroendocrine Tumor Research Advances
- Asthma and respiratory diseases
- Blood groups and transfusion
- Autoimmune Bullous Skin Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nutrition and Health Studies
- Parvovirus B19 Infection Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Vascular Malformations and Hemangiomas
- Parkinson's Disease Mechanisms and Treatments
- Abdominal Trauma and Injuries
- Congenital Ear and Nasal Anomalies
- Gastrointestinal disorders and treatments
- Soft tissue tumor case studies
- Eosinophilic Disorders and Syndromes
- Skin Protection and Aging
Masaryk University
2011-2024
St. Anne's University Hospital Brno
2012-2024
University Hospital Brno
2012-2024
Ocní klinika
2018
BackgroundPredominantly antibody deficiencies (PADs) are the most prevalent primary immunodeficiencies, but their B-cell defects and underlying genetic alterations remain largely unknown.ObjectiveWe investigated patients with PADs for distribution of 41 blood plasma cell (PC) subsets, including subsets defined by expression distinct immunoglobulin heavy chain subclasses.MethodsBlood samples from 139 PADs, 61 common variable immunodeficiency (CVID), 68 selective IgA deficiency (IgAdef), 10...
Despite the progress in understanding how COVID-19 infection may impact immunocompromised patients, data on inborn errors of immunity (IEI) remain limited and ambiguous. Therefore, we examined risk severe course hospital admission a large cohort patients with IEI. In this multicenter nationwide retrospective survey-based trial, demographic, clinical, laboratory were collected by investigating physicians from 8 national referral centers for diagnosis treatment IEI using COVID-19-IEI clinical...
Common variable immunodeficiency disorders (CVID) represent a group of primary diseases characterized by hypogammaglobulinemia and impaired specific Ab response, resulting in recurrent infections due to dysfunctional immune response. The mechanisms mediating deficiency CVID remain be determined. Previous studies indicated that dysregulation patients is associated with chronic microbial translocation, systemic activation, altered homeostasis lymphocytic myeloid lineages. A detailed...
Abstract Surface IgD is coexpressed with IgM on naive mature B cells. Still, the role of surface remains enigmatic even 50 y after its initial discovery. In this study, we examined in vivo human cell homeostasis and Ab responses four individuals heterozygous nonsense mutations IGHD. All IGHD had normal numbers cells serum Igs did not show signs immunodeficiency or immune dysregulation. IgD+ IgD− were present equal showed similar immunophenotypes, except for decreased expression CD79b subset....
Common variable immunodeficiency disorders (CVIDs) represent a group of primary diseases characterized by hypogammaglobulinemia and dysfunctional immune response to invading pathogens. Previous studies have indicated that CVID is associated with microbial translocation systemic myeloid cell activation. The goal this study was determine whether patients display elevated levels markers granulocyte activation the are further influenced intravenous immunoglobulin (IVIg) infusions. plasma...
Secondary immunodeficiencies (SID) represents heterogeneous group of acquired impairment immune system function with diverse etiology. It is mostly a combined disorder both humoral and cellular component the innate adaptive response. SID occurs mainly in adulthood. Among most important causes development belong diabetes mellitus, liver kidney functions, protein-energy malnutrition, splenic defects immunosenescence. These deficiencies immunity are clinically manifested by an increased...
Abstract Common variable immunodeficiency disorder (CVID) is the most common form of primary antibody immunodeficiency. Due to low levels, CVID patients receive intravenous or subcutaneous immunoglobulin replacement therapy as treatment. associated with chronic activation granulocytes, including an increased percentage low‐density neutrophils (LDNs). In this study, we examined changes in LDNs and expression their surface markers 25 27 healthy donors (HD) after vitro stimulation whole blood...
A disease associated with immunoglobulin IgG4 is a rare unit very variable symptoms. We describe the course and treatment of in patient who presented multiple lymphadenopathy infiltrates area retroperitoneum pelvis signs chronic sclerosing pancreatitis. The was clinically manifested by significant loss weight, but also perception taste smell. diagnosis made based on high amount expressing plasma cells sampled tissue an increased concentration immunoglobulins type IgG mainly subclass IG4....
Respiratory allergies mostly allergic rhinitis and asthma represent an important increasing public health problem one of the priorities for European systems. There is concern regarding persistence severity diseases many difficulties systems in providing prompt specialized medical assistance. Our study aims to highlight main results Alliance 4Life project focused on evaluation burden management respiratory primary care from Romania comparative health-related data four Central Eastern countries.
Background Previous research showed that the intracellular complement system, with CD46 as its central molecule, regulates Th1 response associated IFN-γ production and transition to a type 1 regulatory (Tr1) characterized by IL-10 production. This can be influenced vitamin D (calcitriol), favouring shift towards Tr1 cells increased production, described in some autoimmune diseases. Objective It is unknown whether calcitriol modulates CD46-induced T allergic eosinophilic asthma value relation...
Idiopathic retroperitoneal fibrosis is characterized by the development of inflammatory infiltrates with marked along large vessels. Rituximab in combination glucocorticoids constitute an effective therapy, but responses are not long-lasting. In other similar situations, addition cyclophosphamide to achieved longer and deeper responses. This was reason use triple this case.
Vrozené poruchy imunitního systému (PID/IEIs) představují dynamicky se rozvíjející skupinu onemocnění, která je kromě zvýšené náchylnosti k infekcím charakterizována také výskytem autoimunitních, autoinflamatorních, alergických a maligních komplikací. V dnešní době bylo popsáno kolem 500 těchto onemocnění jejich počet neustále zvyšuje. Výsledkem dynamickému pokroku v diagnostice terapii rozvoj genetické diagnostiky, zavedení screeningového vyšetření PID/IEIs u novorozenců, stejně tak jako...
Interstitial lung processes (IPP), or diffuse parenchymal diseases, are a broad group of diseases characterized by varying degrees pulmonary fibrosis and inflammation affecting predominantly, but not exclusively, interstitium. IPP mostly occur in adulthood with maximum manifestation between 40 70 years age. Although present as primary diagnosis, they also belong to the portfolio disorders patients immunodeficiencies. The authors case reports interstitial involvement immunodeficiencies...
IgG4 related disease (IgG4-RD) is a rare and relatively new group of systemic inflammatory diseases characterized by inflammatory, fibrotic or sclerotic involvement one more organs accompanied increased IgG4plasma cells tissue infiltration andusually elevated serum IgG4(IgG4 > 1.35g/l, normal range 0.08-1.40 g/l) level. Histopathological findings are crucial for the diagnostics this disease. The authors present case report patient with associated manifested combination autoimmune...
Immunosenescence is characterized by remodeling and dysregulation of immune system due to aging process. These changes affect innate as well adaptive immunity. Due the complexity physiological processes, in which mechanisms interfere, also other systems organism are affected these changes. Thymus involution chronic antigenic stimulation main causes immunosenescence lead a proinflammatory setting organism. In addition impaired response against infections or reactivation latent infections,...
SouhrnVýchodiska: IgG4 tvoří nejméně zastoupenou podtřídu imunoglobulinů G (IgG) a od ostatních protilátek se odlišují svými zvláštními vlastnostmi.I když jejich funkce v imunitní odpovědi není zcela jasná, uplatňují zejména regulaci odpovědi.IgG4 je tvořen důsledku chronické nebo silné antigenní stimulace, přičemž takové situaci stává dominantně tvořenou podtřídou IgG.IgG4 hrají klíčovou roli toleranci u alergií nádorů.Tolerogenní potenciál uplatňuje léčbě alergických onemocnění pomocí...