A5039949996- Immunodeficiency and Autoimmune Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immune Cell Function and Interaction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- T-cell and B-cell Immunology
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Blood disorders and treatments
- Asthma and respiratory diseases
- Electrowetting and Microfluidic Technologies
- Immunotherapy and Immune Responses
- Mast cells and histamine
- Cell Adhesion Molecules Research
- Plant tissue culture and regeneration
- Blood Coagulation and Thrombosis Mechanisms
St. Anne's University Hospital Brno
2018-2024
Masaryk University
2018-2024
University Hospital Brno
2019-2024
Paul Ehrlich Institut
2021
Common variable immunodeficiency disorders (CVID) represent a group of primary diseases characterized by hypogammaglobulinemia and impaired specific Ab response, resulting in recurrent infections due to dysfunctional immune response. The mechanisms mediating deficiency CVID remain be determined. Previous studies indicated that dysregulation patients is associated with chronic microbial translocation, systemic activation, altered homeostasis lymphocytic myeloid lineages. A detailed...
Abstract Tumor Necrosis Factor Receptor 2 (TNFR2) expression is increasingly being linked to tolerogenic immune reactions and cells with suppressor function including a subset of T‐regulatory cells. B‐regulatory play an important role in control T‐cell responses inflammation. Recently, we described TNFR2 as marker for IL‐10‐producing B cells, hallmark this cell subset. Here, demonstrate that proliferation T reduced the presence positive human memory generated TLR9 ligand, while TNFR2‐...
Neutrophils impact on processes preceding the formation of bradykinin, a major swelling mediator in hereditary angioedema (HAE), yet their potential role HAE pathogenesis has not been sufficiently studied. We assessed relative mRNA expression 10 genes related to neutrophil activation using RNA extracted from peripheral blood neutrophils 23 patients symptom-free period and 39 healthy donors. Increased levels CD274, IL1B, IL1RN, IL8, MMP9, TLR4, together with lack mutual correlations detected...
Abstract Common variable immunodeficiency disorder (CVID) is the most common form of primary antibody immunodeficiency. Due to low levels, CVID patients receive intravenous or subcutaneous immunoglobulin replacement therapy as treatment. associated with chronic activation granulocytes, including an increased percentage low‐density neutrophils (LDNs). In this study, we examined changes in LDNs and expression their surface markers 25 27 healthy donors (HD) after vitro stimulation whole blood...
Background Previous research showed that the intracellular complement system, with CD46 as its central molecule, regulates Th1 response associated IFN-γ production and transition to a type 1 regulatory (Tr1) characterized by IL-10 production. This can be influenced vitamin D (calcitriol), favouring shift towards Tr1 cells increased production, described in some autoimmune diseases. Objective It is unknown whether calcitriol modulates CD46-induced T allergic eosinophilic asthma value relation...
Background. RTX, an anti-CD20 monoclonal antibody, added to chemotherapy has proven be effective in children and adolescents with high-grade, high-risk matured non-Hodgkin lymphoma. RTX leads prompt CD19+ B lymphocyte depletion. However, despite preserved immunoglobulin production by long-lived plasmablasts after treatment, patients remain at risk of prolonged hypogammaglobulinemia. Further, there are few general guidelines for immunology laboratories clinical feature monitoring...
Hereditary angioedema (HAE) is a rare genetic disorder with variable expressivity even in carriers of the same underlying defect, suggesting other and epigenetic factors participate modifying HAE severity. Recent knowledge indicates role immune cells several aspects pathogenesis, which makes monocytes macrophages candidates to mediate these effects. Here we combined search for phenotype gene variants characterization selected genes' mRNA levels monocyte symptom-free period. While no such...