A5054416766- Health Systems, Economic Evaluations, Quality of Life
- Clinical practice guidelines implementation
- Meta-analysis and systematic reviews
- Gut microbiota and health
- Nutritional Studies and Diet
- Statistical Methods and Inference
- Prostate Cancer Diagnosis and Treatment
- Insurance, Mortality, Demography, Risk Management
- Health disparities and outcomes
- Chronic Disease Management Strategies
- Advanced Causal Inference Techniques
- Immunodeficiency and Autoimmune Disorders
- Statistical Methods in Clinical Trials
- Emergency and Acute Care Studies
- Blood disorders and treatments
- Statistical Methods and Bayesian Inference
- Genomics, phytochemicals, and oxidative stress
- Urinary Bladder and Prostate Research
- Immune Cell Function and Interaction
- Prostate Cancer Treatment and Research
- Pharmaceutical Practices and Patient Outcomes
- Dementia and Cognitive Impairment Research
- Global Cancer Incidence and Screening
- Primary Care and Health Outcomes
- Plant-derived Lignans Synthesis and Bioactivity
University of Freiburg
2016-2025
University Medical Center Freiburg
2011-2021
Institute for Cancer Prevention
2021
Zimmer Biomet (Germany)
2012-2015
University of California, Irvine
2008
In order to build a common data pool and estimate the disease burden of primary immunodeficiencies (PID) in Europe, European Society for Immunodeficiencies (ESID) has developed an internet-based database clinical research on patients with PID. This is platform epidemiological analyses as well development new diagnostic therapeutic strategies identification novel disease-associated genes. Since its start 2004, 13,708 from 41 countries have been documented ESID database. Common variable...
Research on hospital-acquired infections (HAIs) requires the highest methodological standards to minimize risk of bias and avoid misleading interpretation. There are two major issues related specifically studies in this area, namely timing infection occurrence so-called competing risks, which deserve special attention. Just as a patient who acquires serious during hospital admission needs appropriate antibiotic treatment, data being collected need statistical analysis. We illustrate urgent...
In 2009, a federally funded clinical and research consortium (PID-NET, http://www.pid-net.org) established the first national registry for primary immunodeficiencies (PID) in Germany. The contains genetic information on PID patients is set up within framework of existing European Database Primary Immunodeficiencies, run by Society Immunodeficiencies. Following example other registries, central data entry clerk has been employed to support at participating centres. Regulations ethics...
An essential role of the gut microbiota in health and disease is strongly suggested by recent research. The composition modified multiple internal external factors, such as diet. A vegan diet known to show beneficial effects, yet unclear. Within a 4-week, monocentric, randomized, controlled trial with parallel group design (vegan (VD) vs. meat-rich (MD)) 53 healthy, omnivore, normal-weight participants (62% female, mean 31 years age), fecal samples were collected at beginning end analyzed...
Background: The goal of evidence-based medicine is to make clinical decisions based on the best available, relevant evidence. For this be possible, studies such as randomized controlled trials (RCTs), which are widely considered provide evidence all forms primary research, must visible and have an impact practice guidelines. We further investigated publicly commercially sponsored RCTs guidelines by measuring direct indirect impactful citations time guideline impact. Methods: sample from...
Abstract Background The goal of evidence-based medicine is to make clinical decisions based on the best available, relevant evidence. For this be possible, studies such as randomized controlled trials (RCTs), which are widely considered provide evidence all forms primary research, must visible and have an impact practice guidelines. We further investigated publicly commercially sponsored RCTs guidelines by measuring direct indirect impactful citations time guideline impact. Methods sample...
Background Information regarding the prevalence of infectious diseases (IDs) in child and adolescent refugees Europe is scarce. Here, we evaluate a standardized ID screening protocol cohort unaccompanied refugee minors (URMs) municipal region southwest Germany. Methods findings From January 2016 to December 2017, employed structured questionnaire screen 890 URMs. Collecting sociodemographic information medical history, also performed diagnostics panel, including complete blood count, urine...
Abstract Background To investigate infectious and non-infectious complications after transperineal prostate biopsy (TPB) without antibiotic prophylaxis in a multicenter cohort. Secondly, to identify whether increasing the number of cores was predictive for occurrence complications. Thirdly, examine relation between TPB erectile dysfunction. Methods We analyzed retrospective cohort 550 patients from three different urological centers undergoing prophylaxis. The median 26. Demographic clinical...
The interest in fermented food products has been increasing recent years. Details about their microbial composition and the effects of consumption on human gut microbiome are particular interest. However, evidence regarding potential to increase diversity, a measure likely associated with health, is lacking. To address this, we analyzed commercially available vegetables using 16S rRNA sequencing. We also conducted pilot study assess feasibility studying regular microbiome. Six healthy male...
Abstract Oral hygiene products containing tin are suitable to prevent erosive tooth wear, yet effects on the oral microbiota not known yet. Therefore, this study determined salivary microbiome of 16 participants using with stannous ions for three years (TG) compared a control group (CG) assess their influence microbiota. Participants were included in randomized controlled clinical trial (RCT) biannual visits. Illumina Miseq sequencing revealed as most abundant genera: Streptococcus (TG...
ABSTRACT The identification of similar patient pathways is a crucial task in healthcare analytics. A flexible tool to address this issue are parametric competing risks models, where transition intensities may be specified by variety distributions, thus particular being possibly time‐dependent. We assess the similarity between two such models examining transitions different health states. This research introduces method measure maximum differences over time, leading development test procedure...
The present human intervention trial investigated the health-promoting potential of B. carinata, with a focus on effects thermal processing bioactivity. Twenty-two healthy subjects consumed carinata preparation from raw (allyl isothiocyanate-containing) or cooked (no allyl isothiocyanate) leaves for five days in randomized crossover design. Peripheral blood mononuclear cells were exposed to aflatoxin B1 (AFB1), without metabolic activation using S9 mix, and subsequently analyzed DNA damage...
The debate about the value of biomedical publications led to recommendations for improving reporting quality. It is unclear what extent these have been endorsed by journals. We analyzed whether specific were included in author instructions, which journal characteristics associated with their endorsement, how endorsement domains changed and was change impact factor between 2010 2015.We considered two study samples consisting "Hematology" "Oncology" journals Journal Citation Report 2008 2014,...
Abstract Background Older patients at risk of functional decline are frequently affected by polypharmacy. This is associated with a further loss independence. However, relationship between disability and medications, such as ‘Potentially Inappropriate Medications’ (PIMs) ‘Potential Prescribing Omissions’ (PPOs), itemised for (de) prescribing in practice-orientated medication lists, has yet to be established. Methods As part randomised comparative effectiveness trial, LoChro , we conducted...