A5068099345- Neonatal and fetal brain pathology
- Cerebral Palsy and Movement Disorders
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Metabolism and Genetic Disorders
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Infectious Encephalopathies and Encephalitis
- Neonatal Health and Biochemistry
- Hip disorders and treatments
- Infant Development and Preterm Care
- Thermal Regulation in Medicine
- Bone fractures and treatments
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Neurogenetic and Muscular Disorders Research
- Neuroscience of respiration and sleep
- Cardiac Arrest and Resuscitation
- Airway Management and Intubation Techniques
- Inflammasome and immune disorders
- Traumatic Brain Injury and Neurovascular Disturbances
Trinity College Dublin
2017-2024
National Maternity Hospital
2019-2021
National Children’s Research Centre
2017-2021
Children's Health Ireland at Crumlin
2019-2021
St Michael’s Hospital
2021
Mater Misericordiae University Hospital
2021
University College Dublin
2021
Tallaght University Hospital
2017-2020
Our Lady's Hospital
2018
Cork University Hospital
2013
Cytokines are possible mediators of neuroinflammation and associated with adverse outcome in neonatal encephalopathy (NE). Our aim was to explore cytokine response children Neonatal Encephalopathy (NE) at school age compared age-matched controls.Follow up age, who had NE controls were assessed for their responses neurodevelopment outcome. Pro- anti-inflammatory cytokines the serum, [Interleukin (IL)-1α, IL-1β, IL-2, IL-6, IL-8, IL-18, Tumor necrosis factor (TNF)-α, TNF β, Interferon (IFN)-γ,...
Aim To examine pro‐ and anti‐inflammatory cytokines in children with cerebral palsy (CP) at baseline response to endotoxin (lipopolysaccharide), correlate outcomes compared age‐matched comparisons, evaluate their ability mount an immune response. Method Serum were assessed 12 (eight males, four females; mean age 10y 1mo [SD 1y 8mo], 6–16y) CP against comparisons 9y 1mo]). Pro‐ (interleukin‐1β, interleukin‐2, interleukin‐6, interleukin‐8, interleukin‐10, interleukin‐18, tumour necrosis factor...
We enumerated conventional and innate lymphocyte populations in neonates with neonatal encephalopathy (NE), school-age children post-NE, cerebral palsy age-matched controls. Using flow cytometry, we demonstrate alterations circulating T, B natural killer cell numbers. Invariant T Vδ2+ γδ numbers frequencies were strikingly higher NE, post-NE compared to controls, whereas mucosal-associated invariant cells Vδ1 depleted from palsy. Upon stimulation ex vivo, cells, Vδ2 NE more readily produced...
Introduction: Neonatal encephalopathy (NE) is associated with coagulation abnormalities. We aimed to investigate the serial alterations in profiles term infants NE and correlate their clinical outcomes. This was a prospective cohort study tertiary referral, university-affiliated maternity hospital. Neonates exposed perinatal asphyxia were recruited (n = 82) 39 received therapeutic hypothermia. Infants had tests including platelets, prothrombin time (PT), activated partial thromboplastin...
Neonatal encephalopathy (NE) is characterized by altered neurological function in term infants and inflammation plays an important pathophysiological role. Inflammatory cytokines interleukin (IL)-1β, IL-1ra IL-18 are activated the nucleotide-binding oligomerization domain (NOD)-, leucine-rich repeat (LRR)- NOD-like receptor protein 3 (NLRP3) inflammasome; furthermore, we aimed to examine role of inflammasome multiprotein complex involved proinflammatory responses from newborn period...
The immune system is inexperienced before birth and tends to be tolerogenic, rather than immunogenic. After birth, the adaptive develops while facing microbial challenges, but it can become impaired as old age progresses persistent inflammation lead chronic morbidity, disability frailty. To investigate potential contributions of lymphocyte subsets immunity from until age, we enumerated circulating innate conventional lymphocytes measured serum cytokine levels in 10 cord blood samples...
<h3>Background</h3> A variety of suction catheters (type, size and design) are recommended for oropharyngeal suctioning meconium during newborn resuscitation, but it is not known which performs best. In this study we compared different sizes soft catheters, the Yankauer (YK) portable bulb syringe (BS), in a solution varying viscosity. <h3>Methods</h3> Simulated (SM) was made using commercial canned pea soup two strengths, full-strength thick-particulate (TP) 50% strained diluted with water,...
Neonatal encephalopathy (NE) is associated with altered cognitive, motor, sensory abilities and behavioural outcomes. This case-control study aimed to assess whether Quality of Life (QoL) sleep disorders are affected in older children following NE compared age-matched controls.Children at school-age post-NE were recruited controls. Sleep QoL assessed the Pediatric Inventory Child Habit Questionnaire.One hundred an age range 4-6 years, including (n=45) controls (n = 55). Significantly higher...
Abstract Background: Cytokines are possible mediators of neuroinflammation and associated with adverse outcome in neonatal encephalopathy (NE) . Our aim was to explore cytokine response children Neonatal Encephalopathy at school age compared age-matched controls. Method: Follow up age, who had NE controls were assessed for their responses neurodevelopment outcome. Pro- anti-inflammatory cytokines the serum, [Interleukin (IL)-1α, IL-1β, IL-2, IL-6, IL-8, IL-18, Tumor necrosis factor (TNF)-α,...
Abstract Background: Cytokines are possible mediators of neuroinflammation and associated with adverse outcome in neonatal encephalopathy (NE) . Our aim was to explore cytokine response children Neonatal Encephalopathy at school age compared age-matched controls. Method: Follow up age, who had NE controls were assessed for their responses neurodevelopment outcome. Pro- anti-inflammatory cytokines the serum, [Interleukin (IL)-1α, IL-1β, IL-2, IL-6, IL-8, IL-18, Tumor necrosis factor (TNF)-α,...
Abstract Objective: Cytokines are possible mediators of neuroinflammation and associated with adverse outcome in neonatal encephalopathy (NE). Our aim was to explore cytokine response children Neonatal Encephalopathy (NE) at school age compared age-matched controls. Method: Follow up age, who had NE controls were assessed for their responses neurodevelopment outcome. Pro- anti-inflammatory cytokines the serum, [Interleukin (IL)-1α, IL-1β, IL-2, IL-6, IL-8, IL-18, Tumor necrosis factor...