<b><i>Background:</i></b> Infants with neonatal encephalopathy (NE) of hypoxic-ischaemic origin are at risk oxidative and ischaemia-reperfusion injury, which may induce abnormal inflammatory responses involving excessive cytokine production release in serum cerebrospinal fluid (CSF). Systemic inflammation is found infants NE, we therefore were interested cytokines associated hypoxia, including vascular endothelial growth factor (VEGF) erythropoietin (Epo)....

This study aimed to assess vitamin D status, and its determinants, in paediatric patients with suspected sepsis who were admitted a intensive care unit (PICU). We also investigated the association between status clinical outcomes.Serum 25-hydroxy (25OHD) determinants prospectively assessed children (<12 years old) PICU. The relationship 25OHD outcomes was evaluated. Vitamin control of similar age.We enrolled 120 PICU 30 controls. <50 nmol/L 59% lower than controls (47 ± 29 vs 66 26 nmol/L, p...

Perinatal asphyxia is associated with multi-organ injury including acute kidney (AKI). New urinary biomarkers may detect more subtle renal injury.Urinary (albumin, beta-2 microglobulin, cystatin-C, epidermal growth factor, neutrophil gelatinase-associated lipocalin, osteopontin, uromodulin) were serially measured from days 1 to 7 in term infants perinatal and controls compared 'Kidney Disease Improving Global Outcome' scoring of encephalopathy grade.A total 255 urine samples taken exposed (n...

Aim: To investigate the relationship between cytokines associated with innate immune cell activation and brain injury outcome in infants NE compared to neonatal controls. Methods: Serum CSF biomarkers activated neutrophils monocytes [Interleukin-8 (IL-8) Granulocyte-Macrophage-Colony-Stimulating-Factor (GM-CSF)] were serially measured using duplex immunoassays on days 1, 3 7 term newborns Results grade of encephalopathy, seizures, MRI imaging, mortality Bayley Score Infant Toddler...

Background. Vitamin D has important skeletal and extraskeletal roles but those living at northerly latitudes are risk of suboptimal levels because reduced sunlight exposure. Aim. To describe the vitamin status Irish children identify factors predictive status. Methods. A prospective cross sectional study was undertaken over a 12 month period. Two hundred fifty two healthy attending for minor medical or surgical procedures were recruited. All had 25-hydroxyvitamin (25OHD), parathyroid hormone...

Troponin is a sensitive marker of asphyxia in term infants mirroring the myocardial injury sustained global hypoxia-ischaemia. In addition, troponin severity stroke adults and neonatal encephalopathy (NE). We aimed to examine relationship between T with perinatal brain on MRI correlate neurodevelopmental outcome.Serum was sampled requiring resuscitation at birth and/or tertiary referral centre. Birth history, clinical parameters, neuroimaging developmental outcome (Bayley Scores Infant...

The timely administration of intrapartum antibiotic prophylaxis (IAP) to eligible pregnant mothers reduces the risk early onset Group B Streptococcus (GBS) neonatal sepsis. incidence GBS sepsis is increasing, in spite national guidelines for its prevention. This retrospective cohort study was undertaken assess culture-proven before and after a change practice on management babies born at Sunderland Royal Hospital between January 1 2008 December 31 2017. data regarding factors, outcomes were...

<b>1329</b> <h3>Objectives</h3> To determine the value of SPECT/CT for detecting and localizing lesions on ¹¹¹In octreotide scintigraphy. <h3>Methods</h3> Forty-eight pts. (61±19 years; 44% males; 56% females) underwent using an integrated SPECT/low energy CT system 24 hrs. after injection 222 MBq ¹¹¹In-octreotide. SPECT data were acquired medium collimators 48 min, &amp; reconstructed by iterative reconstruction, a Butterworth filter with cutoff = 0.7 order 10...

<h3>Background</h3> Term infants with NE of hypoxic-ischaemic origin, have been exposed to generalised oxidative injury which may cause excessive cytokine production and release in serum CSF. Cytokine levels correlate severity brain aid outcome prediction. <h3>Objective</h3> To investigate the relationship between CSF biomarkers a group term perinatal hypoxia-ischaemia compared controls. <h3>Design/Methods</h3> Levels [VEGF, IL-8, Epo, GM-CSF] were serially measured over day 1–11 newborns...

The authors have no conflicts of interest to disclose.

A preterm baby girl born at 25 weeks gestation was evaluated for discharge home. The Senior House Officer asked to prescribe vitamins and iron. He questioned the local guideline found there were no international consensus guidelines vitamin D supplementation in infants on discharge. How much of intake (Intervention) given (patient), would maintain adequacy, ≥50 nmol/L (≥20 ng/mL) (outcome)? ### Primary sources MEDLINE searched via PubMed from 1980 March 2017. advanced search mode used...

Abstract Ojectives Transient neonatal Myasthenia gravis is a postsynaptic neuromuscular junction disorder seen in 10–21% of infants born to mothers with myasthenia gravis. Alemtuzumab an anti-CD52 monoclonal antibody used the treatment multiple sclerosis. The possibility developing pregnant mother treated rare. Case presentation We report case transient following for sclerosis mother. Conclusions Therapy increases risk secondary autoimmune diseases including

Vitamin D is essential for good bone health particularly during infancy, a time of rapid growth.Given Irelands northerly latitude, Irish children are at risk suboptimal vitamin levels.The aim our study was to describe the status group infants and identify factors predictive status.A cross sectional undertaken over 12 month period in single paediatric tertiary referral centre Dublin.Fifty four healthy term (<1 year age) attending hospital minor medical or surgical procedures were...

<h3>Background</h3> Following a perinatal hypoxic-is chaemic insult, term infants are at risk of multi-organ injury including AKI. Infants with NE experience up-regulation urinary cytokines which may reflect severity brain injury. <h3>Objective</h3> To investigate the association between novel biomarkers and outcome in group compared to controls. <h3>Methods</h3> Levels [Albumin, B2M, Cystatin-C, EGF, NGAL, Osteopontin, Uromodulin] were serially measured over day 1–11 newborns These values...

<h3>Introduction</h3> Newborn infants are at risk of vitamin D deficiency and various studies implicate as having immunomodulatory effect. Adequate generation reactive oxygen intermediates (ROI) by neutrophils (PMN) during sepsis is bactericidal. However, production neutrophil oxidase activity in the presence impaired neonates. <h3>Aim</h3> To examine <i><i>in vitro</i></i> effect 1, 25(OH)₂D₃on whole blood PMN monocyte ROI, TLR4, CD11b newborn vitro</i></i>....

<h3>Background</h3> Hypovitaminosis D is widespread among pregnant women and their infants. Recent studies implicate Vitamin as having anti-inflammatory effects which may be beneficial in preterm infants who are at high risk of inflammatory disorders. <h3>Aim</h3> To assess serum 25OHD status NICU mothers any associations between vitamin levels outcome. <h3>Methods</h3> Serum were prospectively evaluated by radioimmunoassay from (&lt; 32 weeks gestation) birth. correlated with outcomes...

<h3>Background</h3> Infection and inflammation can be antecedents of Neonatal Encephalopathy (NE) increase the risk neurological sequelae. Vitamin D is a potent immunomodulator may alter systemic inflammatory repose in NE. <h3>Aim</h3> To investigate <i><i>in vitro</i></i> effect 1,25(OH)₂D₃on whole blood intracellular neutrophil production ROI NE patients at 72–96 h age. <h3>Methods</h3> Infants with were recruited their demographics details, grade NE, MRI results,...