A5023465182- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Neonatal Health and Biochemistry
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Congenital Heart Disease Studies
- Acute Kidney Injury Research
- Fetal and Pediatric Neurological Disorders
- Metabolism and Genetic Disorders
- Infectious Encephalopathies and Encephalitis
- Pregnancy and preeclampsia studies
- Neonatal and Maternal Infections
- Neuroscience of respiration and sleep
- Aortic Disease and Treatment Approaches
- Atomic and Subatomic Physics Research
- Parvovirus B19 Infection Studies
- Thermal Regulation in Medicine
- Infant Development and Preterm Care
- EEG and Brain-Computer Interfaces
- Blood Coagulation and Thrombosis Mechanisms
- Airway Management and Intubation Techniques
- Prenatal Screening and Diagnostics
- Virology and Viral Diseases
- Ethics and Legal Issues in Pediatric Healthcare
- Advanced MRI Techniques and Applications
National Maternity Hospital
2008-2024
Karolinska Institutet
2024
Nationwide Children's Hospital
2024
Centre Hospitalier Universitaire Sainte-Justine
2024
Université de Montréal
2024
Royal College of Surgeons in Ireland
2011-2021
National Children’s Research Centre
2011-2021
Trinity College Dublin
2019-2020
Tallaght University Hospital
2019-2020
Research Network (United States)
2020
<b><i>Background:</i></b> Infants with neonatal encephalopathy (NE) of hypoxic-ischaemic origin are at risk oxidative and ischaemia-reperfusion injury, which may induce abnormal inflammatory responses involving excessive cytokine production release in serum cerebrospinal fluid (CSF). Systemic inflammation is found infants NE, we therefore were interested cytokines associated hypoxia, including vascular endothelial growth factor (VEGF) erythropoietin (Epo)....
Cytokines are possible mediators of neuroinflammation and associated with adverse outcome in neonatal encephalopathy (NE). Our aim was to explore cytokine response children Neonatal Encephalopathy (NE) at school age compared age-matched controls.Follow up age, who had NE controls were assessed for their responses neurodevelopment outcome. Pro- anti-inflammatory cytokines the serum, [Interleukin (IL)-1α, IL-1β, IL-2, IL-6, IL-8, IL-18, Tumor necrosis factor (TNF)-α, TNF β, Interferon (IFN)-γ,...
Abstract Aim Inflammatory cytokines may play a role in the final common pathway pathogenesis of hypoxic‐ischaemic injury experimental models. We aimed to profile systemic pro‐and anti‐inflammatory response over first week life term infants at risk neonatal encephalopathy. Method In tertiary referral university intensive care unit, serial blood samples were analysed from 41 (requiring resuscitation birth) this prospective observational pilot study. Serum levels 10 evaluated including...
Studies suggest that trace element and vitamin deficiencies are common in children with autism spectrum disorder (ASD). Data describing the rates of ASD population northwest Ireland is lacking. We wished to determine prevalence zinc A deficiency compared controls within this geographical area.Parents aged 2-18 years were invited participate study. The control group consisted well attending paediatric department for routine blood sampling. Children on supplements excluded from both groups....
BackgroundMagnetic resonance imaging (MRI) scoring systems are used in the neonatal period to predict outcome infants with encephalopathy. Our aim was assess relationship between three MRI scores and neurodevelopmental assessed using Bayley Scales of Infant Toddler Development, third edition (Bayley-III), at two years encephalopathy.MethodsTerm-born neonates evidence perinatal asphyxia born 2011 2015 were retrospectively reviewed. scanning performed within first weeks life scored Barkovich,...
Perinatal asphyxia is associated with multi-organ injury including acute kidney (AKI). New urinary biomarkers may detect more subtle renal injury.Urinary (albumin, beta-2 microglobulin, cystatin-C, epidermal growth factor, neutrophil gelatinase-associated lipocalin, osteopontin, uromodulin) were serially measured from days 1 to 7 in term infants perinatal and controls compared 'Kidney Disease Improving Global Outcome' scoring of encephalopathy grade.A total 255 urine samples taken exposed (n...
Introduction: Neonatal encephalopathy (NE) is associated with coagulation abnormalities. We aimed to investigate the serial alterations in profiles term infants NE and correlate their clinical outcomes. This was a prospective cohort study tertiary referral, university-affiliated maternity hospital. Neonates exposed perinatal asphyxia were recruited (n = 82) 39 received therapeutic hypothermia. Infants had tests including platelets, prothrombin time (PT), activated partial thromboplastin...
Aim: To investigate the relationship between cytokines associated with innate immune cell activation and brain injury outcome in infants NE compared to neonatal controls. Methods: Serum CSF biomarkers activated neutrophils monocytes [Interleukin-8 (IL-8) Granulocyte-Macrophage-Colony-Stimulating-Factor (GM-CSF)] were serially measured using duplex immunoassays on days 1, 3 7 term newborns Results grade of encephalopathy, seizures, MRI imaging, mortality Bayley Score Infant Toddler...
Neonatal encephalopathy (NE) is characterized by altered neurological function in term infants and inflammation plays an important pathophysiological role. Inflammatory cytokines interleukin (IL)-1β, IL-1ra IL-18 are activated the nucleotide-binding oligomerization domain (NOD)-, leucine-rich repeat (LRR)- NOD-like receptor protein 3 (NLRP3) inflammasome; furthermore, we aimed to examine role of inflammasome multiprotein complex involved proinflammatory responses from newborn period...
Introduction: Melatonin has been suggested an adjunctive therapy in neonatal encephalopathy (NE). reduces oxidative stress and neutrophil activation; however, the immunological effects NE have not studied. Methods: Infants with controls were prospectively recruited. Whole blood was sampled first week of life. Following endotoxin or melatonin treatment, diurnal variation measured by RT PCR for circadian rhythm genes (brain Muscle Arnt-Like protein [BMAL1], locomotor output cycles kaput...
Troponin is a sensitive marker of asphyxia in term infants mirroring the myocardial injury sustained global hypoxia-ischaemia. In addition, troponin severity stroke adults and neonatal encephalopathy (NE). We aimed to examine relationship between T with perinatal brain on MRI correlate neurodevelopmental outcome.Serum was sampled requiring resuscitation at birth and/or tertiary referral centre. Birth history, clinical parameters, neuroimaging developmental outcome (Bayley Scores Infant...
Neonatal encephalopathy (NE) is associated with an increased risk of multi-organ injury. The lack standardised definitions for dysfunction in NE hinders accurate quantification these complications.A simple neonatal scoring (MODE) system was created to include the cardiovascular, respiratory, gastrointestinal, haematological and neurological systems a maximum score 15. MODE then compared grade NE, Bayley Scales Infant Development (Bayley-III) at 2 years age mortality. used as it gave...
Abstract Aim Immune dysregulation and delayed onset of sleep wake cycling (SWC) are associated with worse outcome in neonatal encephalopathy (NE), however the association between immune dysfunction NE remains unclear. Aimed to evaluate systemic inflammation outcomes NE. Methods Amplitude‐integrated electroencephalography (aEEG) recordings were collected on infants undergoing therapeutic hypothermia (TH). Duration quality (SQ) examined. Blood samples during first 2 days life. Thirteen pro‐...
Neonatal encephalopathy (NE) is associated with altered cognitive, motor, sensory abilities and behavioural outcomes. This case-control study aimed to assess whether Quality of Life (QoL) sleep disorders are affected in older children following NE compared age-matched controls.Children at school-age post-NE were recruited controls. Sleep QoL assessed the Pediatric Inventory Child Habit Questionnaire.One hundred an age range 4-6 years, including (n=45) controls (n = 55). Significantly higher...
<h3>Introduction</h3> An elevated white cell count in term newborns with neonatal encephalopathy (NE) has been associated increased risk of mortality and neurological disability. <h3>Aims</h3> To examine the associations between blood (WBC) indices severely asphyxiated infants mortality/neurodevelopmental outcome at 2 years. <h3>Methods</h3> 69 NE were randomized to normothermia or hypothermia as part TOBY trial. Serial WBC parameters, clinical 2-year developmental assessments evaluated 62...