A5080810482- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- interferon and immune responses
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Neonatal and Maternal Infections
- Preterm Birth and Chorioamnionitis
- Cannabis and Cannabinoid Research
- Influenza Virus Research Studies
- Pulmonary Hypertension Research and Treatments
- Infant Nutrition and Health
- Cardiac, Anesthesia and Surgical Outcomes
- Immune cells in cancer
- Inflammation biomarkers and pathways
- Hematological disorders and diagnostics
- Neonatal and fetal brain pathology
- Congenital Heart Disease Studies
- Diet, Metabolism, and Disease
- Sleep and Wakefulness Research
- Infant Development and Preterm Care
- Neuroinflammation and Neurodegeneration Mechanisms
- Intensive Care Unit Cognitive Disorders
Mater Misericordiae University Hospital
2022-2025
Trinity College Dublin
2017-2023
University College Dublin
2023
Regenerative Medicine Institute
2020
Tallaght University Hospital
2017-2018
National Maternity Hospital
2017-2018
Boston Children's Hospital
2017
Royal College of Surgeons in Ireland
2016
Patients at risk of pulmonary hypertension frequently present for emergency orthopedic surgery. A right ventricular systolic pressure 35 mmHg or above, calculated from a tricuspid regurgitant jet on transthoracic echocardiogram, is considered an appropriate screening test hypertension. The aim this study was to evaluate the impact elevated detected preoperative outcomes after hip We undertook retrospective, single centre, case control 98 adult patients who had echocardiogram before...
Immunization is key to preventing infectious diseases, a leading cause of death early in life. However, due age-specific immunity, vaccines often demonstrate reduced efficacy newborns and young infants compared adults. Here we combined vitro vivo approaches identify adjuvant candidates for life immunization. We employed newborn adult bone marrow-derived dendritic cells (BMDCs) perform screening pattern recognition receptor agonists, found that the Stimulator Interferon Genes (STING) ligand...
Abstract Two million infants die each year from infectious diseases before they reach 12 mo; many of these are vaccine preventable in older populations. Pattern recognition receptors represent the critical front-line defense against pathogens. Evidence suggests that innate immune system does not fully develop until puberty, contributing to impaired response infection and responses neonates, infants, children. The activity pattern receptor family cytosolic nucleic acid (CNA) sensors this...
Introduction: Melatonin has been suggested an adjunctive therapy in neonatal encephalopathy (NE). reduces oxidative stress and neutrophil activation; however, the immunological effects NE have not studied. Methods: Infants with controls were prospectively recruited. Whole blood was sampled first week of life. Following endotoxin or melatonin treatment, diurnal variation measured by RT PCR for circadian rhythm genes (brain Muscle Arnt-Like protein [BMAL1], locomotor output cycles kaput...
Efficient and accurate diagnosis of neonatal sepsis is challenging. The potential impact for a reduction in morbidity mortality as well antibiotic usage has stimulated the ongoing search biomarkers early sepsis. objective this pilot study was to quantify levels sTREM-1 correlate with blood cultures inflammatory markers neonates evaluated sepsis.Neonates suspected were enrolled (n = 83; Preterm n 35; Term 48). Routine bloods evaluation included plasma quantified by ELISA.Term preterm 48) 16...
<title>Abstract</title> Patients at risk of pulmonary hypertension (PH) frequently present for emergency orthopedic surgery. A right ventricular systolic pressure (RVSP) 35 mmHg or above, calculated from a tricuspid regurgitant jet on transthoracic echocardiography (TTE) is widely considered an appropriate screening test PH.<sup>1</sup> The aim this study was to evaluate the impact elevated RVSP detected preoperative TTE outcomes after hip replacement fracture fixation We undertook...
Neonates display a marked gender disparity in morbidity and mortality. A higher percentage of premature male than female infants require invasive respiratory support preterm males have incidence lung disease e.g. bronchopulmonary dysplasia (BPD).The TLR4 pathway is an essential component innate immunity results NFκB activation. Many signalling genes are encoded on the X chromosome, including IKBKG/NEMO, IRAK-1, BTK. Genes which escape chromosome inactivation (XCI) may contribute to immune...
Background: Female neonates are well-recognised to have improved outcomes compared males. The mechanisms remain poorly understood, but hormonal influences on immune function may contribute the female advantage during infection and inflammation. aim of this study was investigate in vitro treatment effects 17β-estradiol (E2) its antagonism males versus females CD14+ monocyte cell surface receptor (TLR4, CD11b, ER-α, ER-β) expression reactive oxygen species (ROS) production from mononuclear...