A5015235650- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Neonatal and Maternal Infections
- Infant Development and Preterm Care
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Delphi Technique in Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Fetal and Pediatric Neurological Disorders
- Neuroscience of respiration and sleep
- Cerebral Palsy and Movement Disorders
- Congenital Diaphragmatic Hernia Studies
- Congenital Heart Disease Studies
- Kawasaki Disease and Coronary Complications
- Anesthesia and Neurotoxicity Research
- COVID-19 Clinical Research Studies
- Hip disorders and treatments
- Family and Disability Support Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Advanced Materials Characterization Techniques
- Folate and B Vitamins Research
- Neurogenetic and Muscular Disorders Research
- Thermal Regulation in Medicine
Health Research Board
2021-2024
Karolinska Institutet
2024
Trinity College Dublin
2019-2024
St. James's Hospital
2022-2024
Nationwide Children's Hospital
2024
Centre Hospitalier Universitaire Sainte-Justine
2024
Université de Montréal
2024
Coombe Women & Infants University Hospital
2020-2023
National Children’s Research Centre
2022
Tallaght University Hospital
2021-2022
Abstract Background ‘Neonatal encephalopathy’ (NE) describes a group of conditions in term infants presenting the earliest days after birth with disturbed neurological function cerebral origin. NE is aetiologically heterogenous; one cause peripartum hypoxic ischaemia. Lack uniformity terminology used to describe and its diagnostic criteria creates difficulty design interpretation research complicates communication families. The DEFINE study aims use modified Delphi approach form consensus...
Delphi surveys are commonly used to prioritise critical outcomes in core outcome set (COS) development. This trial aims compare a three-round (Multi-Round) (MRD) with Real-Time (RTD) the prioritisation of for inclusion COS neonatal encephalopathy treatments and explore whether 'feedback', 'iteration', 'initial condition' effects may occur two survey methods.
BackgroundMagnetic resonance imaging (MRI) scoring systems are used in the neonatal period to predict outcome infants with encephalopathy. Our aim was assess relationship between three MRI scores and neurodevelopmental assessed using Bayley Scales of Infant Toddler Development, third edition (Bayley-III), at two years encephalopathy.MethodsTerm-born neonates evidence perinatal asphyxia born 2011 2015 were retrospectively reviewed. scanning performed within first weeks life scored Barkovich,...
Abstract Background The Delphi method is used in a wide variety of settings as building consensus on important issues. Traditionally, the uses multiple rounds survey to allow for feedback other participants’ responses between rounds. By informing participants about how others answer question or prioritise specific topics, it allows diverse opinions inform process. For this reason, popular approach developing core outcome sets (COS), i.e. minimum agreed set standardised outcomes that should...
Objective To identify the outcomes considered important to parents or caregivers of infants diagnosed with neonatal encephalopathy, hypoxic ischaemic encephalopathy birth asphyxia in high-income and low- middle-income countries (LMiCs), as part outcome-identification process developing a core outcome set (COS) for treatment encephalopathy. Design A qualitative study involving 25 semistructured interviews other family members (caregivers) who were with, treated for, asphyxia. Setting...
Abstract Background Neonatal encephalopathy is a complex syndrome in infants that predominantly affects the brain and other organs. The leading cause lack of oxygen blood reaching brain. can result mortality or complications later life, including seizures, movement disorders cerebral palsy. Treatment options for neonatal are limited mainly to therapeutic hypothermia, although potential treatments emerging. However, evaluations effectiveness challenging because heterogeneity inconsistency...
Introduction: Melatonin has been suggested an adjunctive therapy in neonatal encephalopathy (NE). reduces oxidative stress and neutrophil activation; however, the immunological effects NE have not studied. Methods: Infants with controls were prospectively recruited. Whole blood was sampled first week of life. Following endotoxin or melatonin treatment, diurnal variation measured by RT PCR for circadian rhythm genes (brain Muscle Arnt-Like protein [BMAL1], locomotor output cycles kaput...
Background: Neonatal encephalopathy (NE) is associated with adverse neurodevelopmental outcome and linked systemic inflammation. Pro-inflammatory anti-inflammatory cytokines are known to play a role in the pathology of NE by activating innate immune cells. Methods: Eighty-seven infants were enrolled including 53 whom 52 received therapeutic hypothermia (TH) 34 term infant healthy controls (TC). Whole blood sampling was performed first 4 days life, 14-spot ELISA Multiplex Cytokine Array...
Troponin is a sensitive marker of asphyxia in term infants mirroring the myocardial injury sustained global hypoxia-ischaemia. In addition, troponin severity stroke adults and neonatal encephalopathy (NE). We aimed to examine relationship between T with perinatal brain on MRI correlate neurodevelopmental outcome.Serum was sampled requiring resuscitation at birth and/or tertiary referral centre. Birth history, clinical parameters, neuroimaging developmental outcome (Bayley Scores Infant...
Abstract Background Infants with Down syndrome (DS) have an altered immune response. We aimed to characterise the inflammatory response in infants DS and congenital heart disease (CHD) peri-operatively comparison CHD a normal chromosomal complement, healthy pre-operatively. Methods DS/CHD, without but (CHD only) were prospectively recruited serial serum cytokines evaluated using multiplex ELISA: tumour necrosis factor (TNF)-α TNF-β; interferon (IFN)-γ, interleukin (IL)-1α, IL-2, IL-6, IL-8,...
Neonatal encephalopathy (NE) is a significant cause of morbidity and mortality. Persistent inflammation activation leukocytes mediate brain injury in NE. The standard care for NE, therapeutic hypothermia (TH), does not improve outcomes nearly half moderate to severe cases, resulting the need new adjuvant therapies, immunomodulation holds promise. Our objective was explore systemic leukocyte phenotype infants with NE healthy controls response lipopolysaccharide (LPS). Twenty-four (NE II-20;...