A5088672516- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Fetal and Pediatric Neurological Disorders
- Congenital Heart Disease Studies
- Infant Health and Development
- Neonatal Health and Biochemistry
- Family and Patient Care in Intensive Care Units
- Neuroscience of respiration and sleep
- Pediatric Pain Management Techniques
- Congenital Diaphragmatic Hernia Studies
- Music Therapy and Health
- Hemoglobinopathies and Related Disorders
- Atomic and Subatomic Physics Research
- Language Development and Disorders
- Cardiovascular Conditions and Treatments
- Sepsis Diagnosis and Treatment
- Neonatal and Maternal Infections
- Mechanical Circulatory Support Devices
- Retinopathy of Prematurity Studies
- Infectious Encephalopathies and Encephalitis
- Assisted Reproductive Technology and Twin Pregnancy
- Advanced MRI Techniques and Applications
- Pregnancy and preeclampsia studies
National Maternity Hospital
1997-2021
Research Network (United States)
2020
University College Dublin
1997
Mater Hospital
1997
Mater Misericordiae University Hospital
1997
The aim of the study was to measure impact a designated Quiet period on NICU environment and its influence infants' physiological movement responses. group comprised 10 preterm infants assisted ventilation (mean gestational age 28.7 wk (range 24‐32 wk), mean birthweight 1322 g 600‐2060 g), meanage 5.2 d). in which were nursed altered terms reduced light, noise, staff activity infant handling. heart rate, blood pressure, oxygen saturation responses recorded during this compared with Normal...
<h3>Background</h3> There is little consensus regarding the use of echocardiography in patent ductus arteriosus (PDA) treatment preterm infants. The troponin T (cTnT) and N-terminal Pro-BNP (NTpBNP) combination with assessment may facilitate development a superior predictive model. <h3>Objective</h3> To investigate ability cTnT, NTpBNP PDA scoring system applied at 48 h life to predict death before discharge neurodevelopmental outcome 2 years age. <h3>Design/Methods</h3> Infants <32 weeks...
In a prospective study the degree of distress caused by retinopathy prematurity (ROP) screening in cohort preterm infants was assessed and modifying effects nesting reducing their discomfort evaluated.38 were included study. 19 placed nest with boundaries (intervention group) on cot blanket (control group). Observations made 2 minutes before, throughout, after ROP examination. The factors observed crying responses, neurobehavioural activity, physiological changes (heart rate, oxygen...
BackgroundMagnetic resonance imaging (MRI) scoring systems are used in the neonatal period to predict outcome infants with encephalopathy. Our aim was assess relationship between three MRI scores and neurodevelopmental assessed using Bayley Scales of Infant Toddler Development, third edition (Bayley-III), at two years encephalopathy.MethodsTerm-born neonates evidence perinatal asphyxia born 2011 2015 were retrospectively reviewed. scanning performed within first weeks life scored Barkovich,...
Aim: To investigate the relationship between cytokines associated with innate immune cell activation and brain injury outcome in infants NE compared to neonatal controls. Methods: Serum CSF biomarkers activated neutrophils monocytes [Interleukin-8 (IL-8) Granulocyte-Macrophage-Colony-Stimulating-Factor (GM-CSF)] were serially measured using duplex immunoassays on days 1, 3 7 term newborns Results grade of encephalopathy, seizures, MRI imaging, mortality Bayley Score Infant Toddler...
We discuss possible aetiological factors, MRI evolution of injury and neuro-developmental outcomes neonatal encephalopathy (NE). Thirty-six consecutive infants diagnosed with NE were included. In this cohort, four (11%) identified predominantly in the deep white matter on who significantly younger gestation, lower birthweight higher Apgars at one five minutes compared to controls. Placental high grade villitis unknown aetiology (VUA) was all these infants. Our hypothesis states VUA may...
The aim of the study was to measure impact a designated Quiet period on NICU environment and its influence infants' physiological movement responses. group comprised 10 preterm infants assisted ventilation (mean gestational age 28.7 wk (range 24-32 wk), mean birthweight 1,322 g 600-2,060 g), 5.2 d). in which were nursed altered terms reduced light, noise, staff activity infant handling. heart rate, blood pressure, oxygen saturation responses recorded during this compared with Normal...
Troponin is a sensitive marker of asphyxia in term infants mirroring the myocardial injury sustained global hypoxia-ischaemia. In addition, troponin severity stroke adults and neonatal encephalopathy (NE). We aimed to examine relationship between T with perinatal brain on MRI correlate neurodevelopmental outcome.Serum was sampled requiring resuscitation at birth and/or tertiary referral centre. Birth history, clinical parameters, neuroimaging developmental outcome (Bayley Scores Infant...
Neonatal encephalopathy (NE) is associated with an increased risk of multi-organ injury. The lack standardised definitions for dysfunction in NE hinders accurate quantification these complications.A simple neonatal scoring (MODE) system was created to include the cardiovascular, respiratory, gastrointestinal, haematological and neurological systems a maximum score 15. MODE then compared grade NE, Bayley Scales Infant Development (Bayley-III) at 2 years age mortality. used as it gave...
Abstract The pain, distress and emotional upset associated with the administration of neonatal intensive care is being increasingly recognized. We studied preterm infants' response patterns to endotracheal suctioning, one most distressing procedures performed during care. neurobehavioural physiological responses 15 infants were examined. study parameters infant body movement (distal limb, proximal truncal), heart rate oxygen saturation values. movements recorded a video camera. Heart an Ivy...
Abstract Iron is essential for growth and haematopoiesis but iron overload can have detrimental effects. The aim of this study to correlate indices at 1 month age in very low birth weight infants undergoing intensive care prior additional supplementation results with clinical measures 2 year corrected neurodevelopmental outcomes.A prospective observational cohort was undertaken a tertiary neonatal unit. In 45 eligible infants, existed 14 (31%) who had significantly decreased: mean (SD)...
Background: MRI scoring systems are used in the perinatal period to predict later neurodevelopmental outcome infants with neonatal encephalopathy (NE). Our objective was compare predictive ability of 3 for at 2 years age NE. Methods: We retrospectively analysed scans from term-born neonates NE first two weeks life between February 2011 and June 2015 using three systems: Barkovich, NICHD-NRN Weeke. Neurodevelopmental assessed Bayley Scales Infant Toddler Development, third edition...