A5090038285- Folate and B Vitamins Research
- Musculoskeletal pain and rehabilitation
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Cystic Fibrosis Research Advances
- Pelvic floor disorders treatments
- Neonatal Respiratory Health Research
- Esophageal and GI Pathology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Romani and Gypsy Studies
- Cardiac Health and Mental Health
- Health disparities and outcomes
- Anorectal Disease Treatments and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Acute Myocardial Infarction Research
- Gestational Diabetes Research and Management
- Dementia and Cognitive Impairment Research
- Acute Ischemic Stroke Management
- Pelvic and Acetabular Injuries
- Migration, Health and Trauma
- Cardiac, Anesthesia and Surgical Outcomes
- Stroke Rehabilitation and Recovery
- Eosinophilic Esophagitis
- Asthma and respiratory diseases
- Pregnancy and preeclampsia studies
University College Dublin
2011-2024
St. Vincent's University Hospital
1982-2024
Imperial College London
2023
Tallaght University Hospital
2003-2017
Trinity College Dublin
1996-2017
Sports Surgery Clinic
2017
Mater Misericordiae University Hospital
1997-2014
Beaumont Hospital
1994-2014
Connolly Hospital Blanchardstown
2009-2014
Economic and Social Research Institute
2014
Hyperhomocysteinemia arising from impaired methionine metabolism, probably usually due to a deficiency of cystathionine β-synthase, is associated with premature cerebral, peripheral, and possibly coronary vascular disease. Both the strength this association its independence other risk factors for cardiovascular disease are uncertain. We studied extent which could be explained by heterozygous β-synthase deficiency.
Using data from a recent case-control study, woman's risk of having child with neural tube defect (NTD) was found to be associated early pregnancy red cell folate levels in continuous dose-response relationship. These findings were used calculate the reduction NTD cases that would expected under two different strategies raise levels. Targeting high-risk individuals has small effect on population prevalence but can substantially change an individual's risk. produces individual large...
Background —A high plasma homocysteine concentration is a risk factor for atherosclerosis, and circulating concentrations of are related to levels folate vitamin B 6 . This study was performed explore the interrelationships between homocysteine, vitamins, vascular diseases evaluate role these vitamins as factors atherosclerosis. Methods —In multicenter case-control in Europe, 750 patients with documented disease 800 control subjects frequency-matched age sex were compared. Plasma total...
The use of confidence intervals has become standard in the presentation statistical results medical journals. Calculation limits can be straightforward using normal approximation with an estimate error, and particular cases exact solutions obtained from published tables. However, for a number commonly used measures epidemiology clinical research, formulae either are not available or so complex that calculation is tedious. author describes how approach to interval estimation which been...
<i>Background:</i> Prospective population-based studies are important to accurately determine the incidence and characteristics of stroke associated with atrial fibrillation (AF), while avoiding selection bias which may complicate hospital-based studies. <i>Methods:</i> We investigated AF-associated within North Dublin Population Stroke Study, a prospective cohort study stroke/transient ischaemic attack in 294,592 individuals, according recommended criteria for...
Abstract One hundred forty‐five synovial biopsy specimens were obtained from 30 procedures performed on the knee joints of 29 patients with rheumatoid arthritis. All had clinically active arthritis and none received slow‐acting disease‐modifying drugs or intraarticular corticosteroids. Scores assigned to each specimen for 6 histologic features quantify variation within joint. In majority joint biopsies, there was considerable clustering scores all features. Thus, a scale 0–10, 82%...
GRAHAM, IAN M.; DALY, LESLIE E.; REFSUM, HELGA ROBINSON, KILLIAN; BRATTSTRÖM, LARS UELAND, PER PALMA-REIS, ROBERTO J.; BOERS, GODFRIED H.J.; SHEAHAN, RICHARD G.; ISRAELSSON, B O; UITERWAAL, CUNO S.; MELEADY, RAYMOND; McMASTER, DOROTHY; VERHOFF, PETRA; WITTEMAN, JACQUELINE; RUBBA, PAOLO; BELLET, HÉLÈNE; WAUTRECHT, JAN C.; DE VALK, HAROLD W.; SALES LUIS, ARMANDO PARROT-ROULAUD, FRANCOISE TAN, KOK SOON; HIGGINS, ISABELLA; GARCON, DANIELLE; MEDRANO, MARIA JOSÉ; CANDITO, MIRANDE; EVANS, ALUN...
Subjects who stop smoking cigarettes after myocardial infarction have an improved rate of survival compared with those continue, but to date it was not known whether the benefit persisted for more than six years. A total 498 men aged under 60 years had survived a first episode unstable angina or by two were followed up life table methods further 13 Mortality in continued smoke significantly higher (82.1%) stopped (36.9%). These differences increased time. non-smokers initially and...
Objective Mediolateral episiotomy is associated with lower rates of significant perineal tears than midline episiotomy. However, the relationship between precise angle from and risk third‐degree tear has not been established. This study quantifies this relationship. Design Case–control study. Setting National Maternity Hospital, Dublin, Ireland. Sample One hundred primiparous women who had undergone right mediolateral 3 months previously. Methods Two groups were compared. Cases sustained...
Background This study reports the findings of first large-scale Phase III investigator-driven clinical trial to slow rate cognitive decline in Alzheimer disease with a dihydropyridine (DHP) calcium channel blocker, nilvadipine. Nilvadipine, licensed treat hypertension, reduces amyloid production, increases regional cerebral blood flow, and has demonstrated anti-inflammatory anti-tau activity preclinical studies, properties that could have disease-modifying effects for disease. We aimed...
Background and Purpose— Statins improve infarct volume neurological outcome in animal stroke models. We investigated the relationship between statin therapy ischemic North Dublin Population Stroke Study. Methods— A population-based prospective cohort study was performed using rigorous ascertainment methods. Prestroke acute (≤72 hours) poststroke medications were recorded. Modified Rankin score fatality assessed at 7, 28, 90 days 1 year. Results— Of 448 patients, statins prescribed before...
A randomised trial was initiated in Ireland 1981 to determine if periconceptional supplementation with either folic acid alone or a multivitamin preparation could reduce the recurrence risk of neural tube defects (NTDs) women previously affected pregnancy from 5.0% 1.0% less. The concluded before initial target number study subjects reached and without clear treatment effect being observed. total 354 were receive one three treatments: acid, multivitamins plus multivitamins. At end 257 had...
Homozygosity for the T allele of C677T polymorphism gene encoding folate dependent enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) is a risk factor neural tube defects. 1 Both homozygous (TT) and heterozygous (CT) genotypes are associated with lower tissue concentrations folate, higher homocysteine concentrations, activity than wild type (CC) genotype; these effects more marked in homozygotes.Low raised levels early pregnancy factors 2 We investigated possibility that CT genotype...
<b>Aim:</b> The aims of this study were to determine the reliability, responsiveness and minimally important change score Multiple Sclerosis Impact Scale (MSIS)-29 physical using Expanded Disability Status (EDSS) as an anchor measure. <b>Methods:</b> 214 patients with multiple sclerosis (MS) (EDSS 0–8.5) had concurrent MSIS-29 EDSS assessments at baseline up 4 years follow-up. <b>Results:</b> 116 unchanged scores. Stability (mean 0.1 points) was better in 85 0–5.0 than 31 5.5–8.5 whom fell...
Transient ischemic attack (TIA) etiologic data and the ABCD(2) score may improve early stroke risk prediction, but studies are required in population-based cohorts. We investigated external validity of score, carotid stenosis, atrial fibrillation for prediction recurrent after TIA.Patients with TIA North Dublin city population (N=294 529) were ascertained by using overlapping hospital community sources. The relations between individual items, fibrillation, examined.In confirmed cases...
Suicidal behaviour is known to aggregate in families. Patients with psychiatric disorders are at higher risk for suicide attempts (SA), however protective and genetic variants appear be independent of underlying disorders. Here we investigate genes important neurobiological pathways linked suicidal and/or associated endophenotypes, association SA among patients co-existing illness. Selected gene-gene gene-environment interactions were also tested. DNA was obtained from bloods 159 (76...
Genetic factors play a role in chronic obstructive pulmonary disease (COPD) but are poorly understood. A number of candidate genes have been proposed on the basis pathogenesis COPD. These include matrix metalloproteinase (MMP) which tissue remodelling and fit with protease - antiprotease imbalance theory for cause Previous genetic studies MMPs COPD had inadequate coverage genes, reported conflicting associations both single nucleotide polymorphisms (SNPs) SNP haplotypes, plausibly due to...