A5065693607- Suicide and Self-Harm Studies
- Treatment of Major Depression
- Tryptophan and brain disorders
- Electroconvulsive Therapy Studies
- Bipolar Disorder and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Treatment and Access
- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Innovations in Medical Education
- Schizophrenia research and treatment
- Mental Health Research Topics
- Psychosomatic Disorders and Their Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Grief, Bereavement, and Mental Health
- Personality Disorders and Psychopathology
- Healthcare professionals’ stress and burnout
- Stress Responses and Cortisol
- Homicide, Infanticide, and Child Abuse
- Posttraumatic Stress Disorder Research
- Attention Deficit Hyperactivity Disorder
- Neuroscience and Neuropharmacology Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health and Psychiatry
- Body Image and Dysmorphia Studies
RTX (United States)
2025
St. Vincent's University Hospital
2013-2024
University College Dublin
2014-2024
Louisiana State University Health Sciences Center Shreveport
2022-2023
The University of Texas Southwestern Medical Center
2023
Medical University of South Carolina
2022
Edward Via College of Osteopathic Medicine
2022
Louisiana State University in Shreveport
2022
University Hospitals Bristol and Weston NHS Foundation Trust
2021
Saint Vincent Health System
2021
Risk factors for suicide attempts have rarely been studied comprehensively in more than one psychiatric disorder, preventing estimation of the relative importance and generalizability different putative risk across diagnoses. The authors conducted a study patients with mood disorders, psychoses, other Their goal was to determine suicidal acts diagnostic boundaries develop hypothetical, explanatory, predictive model behavior that can subsequently be tested prospective study.Following...
OBJECTIVE: Suicidal behavior is highly prevalent in borderline personality disorder and major depressive episode, although the characteristics of suicide attempts two disorders are believed to differ. Comorbidity episode may obscure that uniquely related psychopathology each disorder. We compared suicidal patients with disorder, plus determine whether differed between groups if aspects core predicted specific attempt characteristics. METHOD: Eighty-one inpatients including 49 were 77 alone...
Traditionally, it has been widely assumed that the likelihood of response to ECT is independent adequacy previous treatment with antidepressant medications. However, recent research raised possibility medication-resistant patients depression have a poorer clinical outcome than who not failed adequate medication trials.Medication resistance 100 primary, unipolar, nonpsychotic major was evaluated during index episode Antidepressant Treatment History Form. Patients were recruited and treated at...
OBJECTIVE: This study investigated whether a higher frequency of reported childhood trauma would be found in depressed adults with levels trait impulsivity, aggression, and suicidal behavior. METHOD: In 136 adult inpatients, the authors assessed aggression history, number lifetime suicide attempts as well medical lethality intent to die associated most lethal attempt. These variables were then compared between those without history physical or sexual abuse. RESULTS: Subjects who an abuse...
Over 30,000 people a year commit suicide in the United States. Prior attempted and hopelessness are most powerful clinical predictors of future completed suicide. The authors hypothesized that "reasons for living" might protect or restrain patients with major depression from making attempt.Inpatients DSM-III-R were assessed depression, general psychopathology, history, reasons living, hopelessness. Of 84 patients, 45 had 39 not.The depressed who not expressed more feelings responsibility...
OBJECTIVE: Neuropsychological deficits in the context of psychiatric disease may be associated with suicide risk. In this study, neuropsychological performance was compared among depressed patients at least one prior attempt high lethality, low-lethality attempts, no and nonpatients. METHOD: Fifty unmedicated a major depressive episode (21 history attempts 14 15 previous low respectively) 22 nonpatients were assessed. Groups comparable age, education, occupational level, estimated premorbid...
OBJECTIVE: The antidepressant action of ECT may be related to its anticonvulsant properties. Positron emission tomography (PET) studies regional cerebral metabolic rate for glucose were used test this hypothesis. METHOD: Ten patients with major depression studied PET before and approximately 5 days after a course bilateral ECT. Statistical parametric mapping was identify regions decreased metabolism. RESULTS: Widespread metabolism identified ECT, especially in the frontal parietal cortex,...
Lower serotonergic activity correlates with high-lethality suicide attempts in major depression. Postmortem studies of serotonin receptors suicides localize changes to the ventral prefrontal cortex (PFC). We studied response PFC depressed patients surviving a attempt.Depressed history attempt (n = 16) were compared those low-lethality 9) for level depression, suicidal intent and ideation, impulsivity, aggression, neuropsychological test performance. Subjects scanned while medication free...
We examined the risk of attempted suicide in 100 inpatients during a major depressive episode. hypothesized that patients who attempt have vulnerability for suicidal behavior independent severity or duration depression, manifested by attempts early course The first 3 months after onset an MDE and 5 years lifetime disorder represented highest-risk period suicide, depression. Familial, genetic, early-life loss experiences comorbid alcoholism may be causal factors.
This study examined the relationship between characteristics of borderline personality disorder and suicidal behavior. The authors hypothesized that a specific feature disorder, impulsivity, childhood trauma, possible etiological factor in development would be associated with behavior.Information on lifetime history behavior was obtained from 214 inpatients diagnosed by structured clinical interview. DSM-III-R criteria met following measures behavior: presence or absence previous suicide...
Mindfulness-based cognitive therapy (MBCT) is a new group-based intervention for prevention of relapse in recurrent depression which has not been scientifically evaluated regarding its clinical effectiveness ameliorating residual depressive symptoms following episode. The aim this study was to assess the efficacy MBCT reducing psychiatric outpatients with depression, and particularly explore effects mindfulness techniques on rumination.The design mixed model complex design. Design 1...
Previous studies have found that not all suicide attempters with major depression reduced serotonergic activity based on low cerebrospinal fluid 5-hydroxyindoleacetic acid (CSF- 5-HIAA) levels. In this study we hypothesized function is lower in depressed patients who carried out high-lethality attempts resulting more medical damage, which might explain differences among attempters. We assessed the relationship of CSF 5-HIAA and other amine metabolites to most lethal lifetime attempt 22...
OBJECTIVE: Cigarette smoking is associated with a higher risk for suicide and attempted suicide, but psychopathological or biological explanations this association have not been explored. Lower serotonin function impulsive/aggressive traits are suicidal acts, including completed suicide. The authors hypothesized that the relationship may exist between cigarette behavior be lower presence of traits. METHOD: Study subjects were 347 patients psychiatric disorder (175 depression, 127...
OBJECTIVE: Suicide rates differ between ethnic groups in the United States. Since suicide is commonly associated with a mood disorder, authors compared relative to depression five METHOD: Rates of major were generated from Epidemiologic Catchment Area study and Hispanic Health Nutrition Survey. Sociodemographic effects determined by examining for respondents who separated or divorced, earning low incomes, not working pay. The survey data analyzed age sex standardization generate 1-year...
Posttraumatic stress disorder (PTSD) increases the risk of suicidal behavior; a major depressive episode also for behavior. The authors' goal was to examine effect comorbid PTSD and on behavior.Inpatients with diagnosis (N=156) were assessed PTSD, behavior, clinical factors acts.Patients more likely have attempted suicide, women both disorders suicide than men disorders. Cluster B personality independently related history attempts.The greater rate attempts among patients not due differences...
Background Patients with major depressive disorder (MDD) who attempt or complete suicide have elevated inflammation compared to nonsuicidal patients MDD. However, greater severity of depression and the medical lethality attempts could account for such in attempters completers. Methods To clarify, we measured inflammatory markers MDD without high levels suicidal ideation nondepressed controls (N = 124). Levels ideation, severity, recent were assessed by structured clinical interviews. A...
For over 25 years, it has been hypothesized that major depression is due to a deficiency of available serotonin or subsensitivity key receptors in relevant brain regions. Direct evidence supporting this hypothesis lacking because the difficulty studying regional serotonergic function. The authors have developed method for visualizing vivo responses release by comparing glucose metabolism after administration serotonin-releasing drug dl-fenfluramine, relative placebo.Results with healthy...
<h3>Background</h3> The Hamilton Depression Rating Scale (HDRS) is widely used to measure the severity of depression in mood disorders. Total HDRS score correlates with brain metabolism as measured by fludeoxyglucose F 18 ([<sup>18</sup>F]-FDG) positron emission tomography. comprises distinct symptom clusters that may be associated different patterns regional glucose metabolism. <h3>Objective</h3> To examine associations between component psychopathologic and resting cerebral assessed...
Article AbstractObjective: Determining risk for a suicide attempt in psychiatric patients requires assessment of multiple factors and knowledge their relative importance. Classification regression tree (CART) analysis generates decision trees that select the variables perform best identifying group interest model clinical making. Hypothetical to identify recent remote attempters, weighted increase sensitivity, were generated using correlates past suicidal behavior. Method: Correlates...
Inflammatory bowel diseases (IBDs) are heterogeneous disorders with complex aetiology. Quantitative genetic studies suggest that only a small proportion of the disease variance observed in IBD is accounted for by variation, indicating potential role differential epigenetic regulation The aim this study was to assess genome-wide DNA methylation changes specifically associated ulcerative colitis (UC), Crohn's (CD) and activity.DNA quantified peripheral blood mononuclear cells (PBMCs) from 149...