A5071373873- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Alzheimer's disease research and treatments
- Aging and Gerontology Research
- Schizophrenia research and treatment
- Frailty in Older Adults
- Geriatric Care and Nursing Homes
- Intergenerational Family Dynamics and Caregiving
- Health Systems, Economic Evaluations, Quality of Life
- Functional Brain Connectivity Studies
- Health, psychology, and well-being
- Health, Environment, Cognitive Aging
- Genetic Associations and Epidemiology
- Stress Responses and Cortisol
- Blood Pressure and Hypertension Studies
- Diet and metabolism studies
- Health and Well-being Studies
- Cholinesterase and Neurodegenerative Diseases
- Sleep and related disorders
- Mental Health and Psychiatry
- Pharmaceutical Practices and Patient Outcomes
- Treatment of Major Depression
- Memory and Neural Mechanisms
- Neurobiology of Language and Bilingualism
- Chronic Disease Management Strategies
Trinity College Dublin
2016-2025
Global Brain Health Institute
2019-2025
St. James's Hospital
2014-2024
University of California, San Francisco
2019-2024
Mercer (Czechia)
2000-2024
Dementia UK
2024
Imperial College London
2023
University of Edinburgh
2023
University of Cambridge
2006-2023
University of Oxford
2023
Background In an 11-country European collaboration, 14 population-based surveys included 21 724 subjects aged ⩾65 years. Most participating centres used the Geriatric Mental State (GMS), but other measures were also used. Aims To derive from these instruments a common depression symptoms scale, EURO–D, to allow comparison of risk factor profiles between centres. Method Common items identified instruments. Algorithms for fitting GMS derived by observation item correspondence or expert...
<b><i>Objective:</i></b> To compare effects of risperidone with placebo (efficacy and tolerability) haloperidol (tolerability) for treating demented patients aggression other behavioral symptoms. <b><i>Methods:</i></b> A 13-week double-blind study involving 344 dementia randomly assigned to receive or flexible doses (0.5 4 mg/d) haloperidol. Behavioral symptoms were assessed by the Behavior Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD), Cohen-Mansfield Agitation Inventory (CMAI),...
Background Late Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified first strongly supported LOAD susceptibility genes since discovery involvement APOE in early 1990s. We have now exploited these GWAS datasets to uncover key pathophysiological processes. Methodology applied a recently developed tool for mining data biologically meaningful information dataset. The principal findings were then tested an independent...
Abstract Objective Both loneliness and social networks have been linked with mood wellbeing. However, few studies examined these factors simultaneously in community‐dwelling participants. The aim of this study was to examine the relationship between network, loneliness, depression, anxiety quality life community dwelling older people living Dublin. Methods One thousand two hundred ninety‐nine aged 65 over, recruited through primary care practices, were interviewed their own homes using...
A frailty paradigm would be useful in primary care to identify older people at risk, but appropriate metrics that level are lacking. We created and validated a simple instrument for screening Europeans aged ≥50. Our study is based on the first wave of Survey Health, Ageing Retirement Europe (SHARE, http://www.share-project.org ), large population-based survey conducted 2004-2005 twelve European countries. Subjects: SHARE Wave 1 respondents (17,304 females 13,811 males). Measures: five...
The COVID-19 global pandemic and subsequent public health social measures have challenged our economic life, with increasing concerns around potentially rising levels of isolation loneliness. This paper is based on cross-sectional online survey data (available in 10 languages, from 2 June to 16 November 2020) 20,398 respondents 101 different countries. It aims help increase understanding the risk factors that are associated loneliness, irrespective culture or country, support evidence-based...
Low n -3 polyunsaturated fatty acid (PUFA) status may be associated with neuro-degenerative disorders, in particular Alzheimer's disease, which has been poor dietary fish or PUFA intake, and low docosahexaenoic (DHA) status. The present case–control study used an established biomarker of intake (serum cholesteryl ester-fatty composition) to determine patients who were free-living the community. All cases fulfilled National Institute Neurological Communicative Disorders Stroke Disease Related...
The enhancing effect of music on autobiographical memory recall in mild Alzheimer’s disease individuals (n = 10; Mini-Mental State Examination score >17/30) and healthy elderly matched 25–30) was investigated. Using a repeated-measures design, each participant seen two occasions: once condition (Vivaldi’s ‘Spring’ movement from ‘The Four Seasons’) silence condition, with order counterbalanced. Considerable improvement found for Alzheimer individuals’ the Autobiographical Memory Interview...
Background This is the first report of results from EURODEP Programme. Aims To assess prevalence depression judged suitable for intervention in randomised samples those aged ⩾65 nine European centres. Method The GMS-AGECAT package. Results Differences are apparent, 8.8% (Iceland) to 23.6% (Munich). When sub-cases and cases added together, five high- four low-scoring centres emerge. Women predominated over men. Proportions revealed striking differences but did not explain prevalence. There...
Data from surveys involving 21,724 subjects aged > or = 65 years were analysed using a harmonised depression symptom scale, the EURO-D.To describe and compare effects of age, gender mental status on depressive symptoms across Europe.We tested for centre, marital EURO-D score. Between-centre variance was partitioned according to centre characteristics: region, religion survey instrument used.EURO-D scores tended increase with women scored higher than men, widowed separated others. The scale...
Background. The protective effects of religion against late life depression may depend on the broader sociocultural environment. This paper examines whether prevailing religious climate is related to cross-cultural differences in elderly Europeans. Methods. Two approaches were employed, using data from EURODEP collaboration. First, associations studied between church-attendance, denomination and at syndrome level for six study centres (five countries, N = 8398). Secondly, ecological computed...
Background and objectives: Cognitive screening is a “first step” in detecting dementia other neuropsychiatric syndromes hence represents an important public health clinical initiative. A plethora of cognitive instruments has been advocated recent years, but the extent to which these are used or their effectiveness not well known. An International Psychogeriatric Association (IPA) survey was designed determine were most frequently by clinicians with special expertise aspects old age also ones...