A5025148109- Drug Transport and Resistance Mechanisms
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Bowel Disease
- Pharmacological Effects of Natural Compounds
- Peroxisome Proliferator-Activated Receptors
- Immune Response and Inflammation
- Child Nutrition and Water Access
- Bone health and osteoporosis research
- Diabetes Management and Research
- Fatty Acid Research and Health
- Esophageal Cancer Research and Treatment
- Bone health and treatments
- Natural product bioactivities and synthesis
- Diabetes Treatment and Management
- Eicosanoids and Hypertension Pharmacology
- Thyroid and Parathyroid Surgery
- Pancreatitis Pathology and Treatment
- Alzheimer's disease research and treatments
- Gastroesophageal reflux and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Vitamin C and Antioxidants Research
- Dementia and Cognitive Impairment Research
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Bone and Joint Diseases
- interferon and immune responses
Royal College of Surgeons in Ireland
2019-2023
Beaumont Hospital
2020-2022
Imperial College London
2022
University of East Anglia
2022
Norwich Research Park
2022
St. James's Hospital
1995-2016
Trinity College Dublin
2016
Low n -3 polyunsaturated fatty acid (PUFA) status may be associated with neuro-degenerative disorders, in particular Alzheimer's disease, which has been poor dietary fish or PUFA intake, and low docosahexaenoic (DHA) status. The present case–control study used an established biomarker of intake (serum cholesteryl ester-fatty composition) to determine patients who were free-living the community. All cases fulfilled National Institute Neurological Communicative Disorders Stroke Disease Related...
Increased epithelial permeability is a key feature of IBD pathogenesis and it has been proposed that agents which promote barrier function may be therapeutic benefit. We have previously reported the secondary bile acid, ursodeoxycholic acid (UDCA), to protective in mouse model colonic inflammation its bacterial metabolism required for beneficial effects. The current study aimed compare effects UDCA, LCA, non-metabolizable analog 6-methyl-UDCA (6-MUDCA), on mucosal inflammation. Bile acids...
With advances in technology, there is an emerging concern that inequalities exist provision and diabetes outcomes areas of greater deprivation. We assess the relationship between socio-economic status deprivation with access to technology their adults type 1 diabetes.Retrospective, observational analysis attending a tertiary centre, comprising three urban hospitals UK. Socio-economic was assessed by English Indices Deprivation 2019. Data performed using one-way ANOVAs chi-squared tests.In...
Humans that are heterozygous for the common S180L polymorphism in Toll-like receptor (TLR) adaptor Mal (encoded by TIRAP) protected from a number of infectious diseases, including tuberculosis (TB), whereas those homozygous allele at increased risk. The reason this difference susceptibility is not clear. We report has TLR-independent role interferon-gamma (IFN-γ) signaling. Mal-dependent IFN-γ (IFNGR) signaling led to mitogen-activated protein kinase (MAPK) p38 phosphorylation and autophagy....
To determine the clinical, functional and neuropsychological correlates of verbal aggression in Alzheimer's disease a group consecutive first attendees to memory clinic.150 people were evaluated diagnosed as suffering with probable disease. These tested using Behave-AD for presence aggression, delusions, depression agitation. They also assessed cognitive, scales.Twenty-eight per cent this Alzheimer patients had exhibited some preceding month. Male gender (p = 0.022), paranoid delusional...
The motility of the vagally denervated transposed stomach after oesophagectomy was examined by ambulatory gastric manometry and videofluoroscopy. Two groups subjects were studied. Group 1 comprised ten patients who had undergone 6-12 months previously group 2 consisted six normal control subjects. Studies performed on fasting fed subjects, following injection erythromycin 8 mg/kg. No distinguishable manometric wave activity seen in either while fasting. Feeding generated a measurable pattern...
Bile acids classically known for their roles in dietary fat absorption are now recognized as hormones critical to regulating intestinal and metabolic function, including mucosal immune responses, epithelial proliferation/apoptosis, transepithelial transport barrier function. Downregulation of the nuclear bile acid receptor, farnesoid X receptor (FXR), epithelium occurs inflammatory bowel disease colorectal cancer, whereas FXR activation prevents progression pre-clinical models. Thus...
Introduction: The nuclear bile acid receptor, farnesoid X receptor (FXR), is expressed on intestinal epithelial cells where its potential as a new drug target for treatment of and metabolic disorders, such chronic diarrhoea, colitis, colon cancer, obesity diabetes, has been well-established. We have previously shown that pentacyclic triterpenes (PCTs), class dietary phytochemical, enhance the expression activity colonic FXR. Here, we investigated if another common polyunsaturated fatty acids...
Background: Increased epithelial cell death leading to compromised intestinal barrier function is a key contributor the pathogenesis of inflammatory bowel disease. Previously published studies suggest that nuclear bile acid receptor, farnesoid X receptor (FXR), promotes and protective against colonic inflammation. Here, we investigated potential mechanisms involved. Methods: Mucosal inflammation was induced in mice by adding 2.5% dextran sulfate sodium (DSS) their drinking water, either with...
Background Increased apoptosis and loss of epithelial barrier function are hallmark features in the pathogenesis inflammatory bowel disease. While bile acids classically known for their roles facilitating digestion absorption fats, they have more recently become appreciated as a family enterocrine hormones that regulate many aspects intestinal function. However, even though changes luminal closely associated with IBD pathogenesis, regulating still largely unknown. Lithocholic acid (LCA) is...
INTRODUCTION Bile acids, classically known for their roles in fat digestion, are now recognised as important regulators of many aspects intestinal physiology, including epithelial proliferation/apoptosis, transport and barrier function. Thus, the nuclear bile acid receptor, farnesoid X receptor (FXR), represents a promising therapeutic target disorders, such inflammatory bowel disease colorectal cancer. Previous studies suggest dietary plant‐derived phytochemicals may modulate FXR activity....
CFTR, a Cl- channel important in regulating intestinal fluid and electrolyte secretion, is implicated the pathogenesis of number disorders. We have previously shown that bile acids, acting via nuclear receptor, farnesoid X receptor (FXR), inhibit colonic epithelial CFTR expression. Dietary phytochemicals been reported to capacity modulate FXR signalling. Here, we set out investigate mechanisms underlying regulation expression, potential for therapeutically targeting with dietary...
The intestinal epithelium forms the interface between body and luminal contents, facilitating fluid electrolyte transport, while also acting as a barrier to harmful pathogens. Dysregulation of transport function is associated with pathogenesis number conditions, including chronic diarrhoeal inflammatory bowel diseases (IBD). Previous studies from ours, other laboratories, have identified nuclear bile acid receptor, farnesoid x receptor (FXR), an excellent target for development new...