A5064830675- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- interferon and immune responses
- Infectious Diseases and Tuberculosis
- vaccines and immunoinformatics approaches
- Immune responses and vaccinations
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- Immune cells in cancer
- Hepatitis B Virus Studies
- Bacteriophages and microbial interactions
- MicroRNA in disease regulation
- Helicobacter pylori-related gastroenterology studies
University College Dublin
2016-2021
Increased glycolytic metabolism recently emerged as an essential process driving host defense against Mycobacterium tuberculosis (Mtb), but little is known about how this regulated during infection. Here, we observe repression of glycolysis in Mtb-infected macrophages, which dependent on sustained upregulation anti-inflammatory microRNA-21 (miR-21) by proliferating mycobacteria. The dampening miR-21 mediated through targeting phosphofructokinase muscle (PFK-M) isoform at the committed step...
Members of the Mycobacterium tuberculosis complex (MTBC) are causative agents in a range mammals, including humans. A key feature MTBC pathogens is their high degree genetic identity yet distinct host tropism. Notably, while bovis highly virulent and pathogenic for cattle, human pathogen M. attenuated cattle. Previous research also suggests that preference amongst members has basis innate immune responses. To explore tropism, we present in-depth profiling reference strains AF2122/97 H37Rv at...
The Mycobacterium tuberculosis complex (MTBC) is the collective term given to group of bacteria that cause (TB) in mammals. It has been reported M. H37Rv, a standard reference MTBC strain, attenuated cattle compared bovis. However, as H37Rv was isolated early 1930s, and genetic variants are known exist, we sought revisit this question attenuation for by performing bovine experimental infection with recent isolate. Here report using bovis AF2122/97, BTB1558, latter 2008 during TB surveillance...
Humans that are heterozygous for the common S180L polymorphism in Toll-like receptor (TLR) adaptor Mal (encoded by TIRAP) protected from a number of infectious diseases, including tuberculosis (TB), whereas those homozygous allele at increased risk. The reason this difference susceptibility is not clear. We report has TLR-independent role interferon-gamma (IFN-γ) signaling. Mal-dependent IFN-γ (IFNGR) signaling led to mitogen-activated protein kinase (MAPK) p38 phosphorylation and autophagy....
The Mycobacterium tuberculosis complex (MTBC) is a group of related pathogens that cause (TB) in mammals. MTBC species are distinguished by their ability to sustain distinct host populations. While bovis (Mbv) sustains transmission cycles cattle and wild animals causes zoonotic TB, M. (Mtb) affects human populations seldom disease cattle. pathogen determinants underlying tropism between still unknown. Macrophages the main cell encounters mycobacteria upon initial infection, we hypothesised...
Abstract Current evolutionary scenarios posit the emergence of Mycobacterium tuberculosis from an environmental saprophyte through a cumulative process genome adaptation. riyadhense, related bacillus, is being increasingly isolated human clinical cases with tuberculosis-like symptoms in various parts world. To elucidate relationship between M. riyadhense and other mycobacterial species, including members complex (MTBC), eight isolates were sequenced analyzed. We show, among features, that...
Abstract Members of the Mycobacterium tuberculosis complex (MTBC) are causative agents in a range mammals, including humans. A key feature MTBC pathogens is their high degree genetic identity, yet distinct host tropism. Notably, while bovis highly virulent and pathogenic for cattle, human pathogen M. attenuated cattle. Previous research also suggests that preference amongst members has basis innate immune responses. To explore tropism, we present in-depth profiling reference strains...
Abstract Current evolutionary scenarios posit the emergence of Mycobacterium tuberculosis , deadliest bacterial pathogen for humans globally, from an environmental saprophyte through a cumulative process genome adaptation. riyadhense is novel non-tuberculous mycobacterium (NTM) that being increasingly isolated human clinical cases with (TB)-like symptoms in various parts world. We provide evidence here M. likely ‘missing link’ our understanding evolution . To elucidate genomic hallmarks...
Abstract The Mycobacterium tuberculosis complex (MTBC) is the collective term given to group of bacteria that cause (TB) in mammals. It has been reported M. H37Rv, a standard reference MTBC strain, attenuated cattle compared bovis . However, as H37Rv was isolated early 1930s, and genetic variants are known exist, we sought revisit this question attenuation for by performing bovine experimental infection with recent isolate. Here report using AF2122/97, BTB1558, latter 2008 during TB...
Abstract The Mycobacterium tuberculosis complex (MTBC) is a group of related pathogens that cause (TB) in mammals. MTBC species are distinguished by their ability to sustain distinct host populations. While bovis (Mbv) sustains transmission cycles cattle and wild animals causes zoonotic TB, M. (Mtb) affects human populations seldom disease cattle. However, the pathogen determinants driving tropism between still unknown. Macrophages main cell encounters mycobacteria upon initial infection we...