A5078280178- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Tryptophan and brain disorders
- Cannabis and Cannabinoid Research
- Autophagy in Disease and Therapy
- Gut microbiota and health
- Antibiotic Resistance in Bacteria
- Ancient and Medieval Archaeology Studies
- Pneumonia and Respiratory Infections
- Archaeological and Geological Studies
- Phagocytosis and Immune Regulation
- Microbial Natural Products and Biosynthesis
- Helicobacter pylori-related gastroenterology studies
- Lipid metabolism and biosynthesis
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Archaeological and Historical Studies
University of Ottawa
2023-2024
Université Paris Cité
2020-2023
Institut Pasteur
2019-2023
Inserm
2019-2023
Délégation Paris 7
2020-2021
Sorbonne Paris Cité
2020-2021
Biology of Infection
2020
Terra
2008
Abstract Depression is the leading cause of disability worldwide. Recent observations have revealed an association between mood disorders and alterations intestinal microbiota. Here, using unpredictable chronic mild stress (UCMS) as a mouse model depression, we show that UCMS mice display phenotypic alterations, which could be transferred from donors to naïve recipient by fecal microbiota transplantation. The cellular behavioral observed in were accompanied decrease endocannabinoid (eCB)...
Introduction Atherosclerosis is a chronic inflammatory disease caused by the deposition of lipids within artery wall. During atherogenesis, efficient autophagy needed to facilitate efferocytosis and cholesterol efflux, limit inflammation lipid droplet buildup, eliminate defective mitochondria protein aggregates. Central regulation transcription factor EB (TFEB), which coordinates expression lysosomal biogenesis genes. In recent years, trehalose has been shown promote TFEB activation protect...
Successful control of Mycobacterium tuberculosis (Mtb) infection by macrophages relies on immunometabolic reprogramming, where the role fatty acids (FAs) remains poorly understood. Recent studies unraveled Mtb’s capacity to acquire saturated and monounsaturated FAs via Mce1 importer. However, upon activation, produce polyunsaturated (PUFAs), mammal-specific mediating generation immunomodulatory eicosanoids. Here, we asked how Mtb modulates de novo synthesis PUFAs in primary mouse whether...
Abstract Current evolutionary scenarios posit the emergence of Mycobacterium tuberculosis from an environmental saprophyte through a cumulative process genome adaptation. riyadhense, related bacillus, is being increasingly isolated human clinical cases with tuberculosis-like symptoms in various parts world. To elucidate relationship between M. riyadhense and other mycobacterial species, including members complex (MTBC), eight isolates were sequenced analyzed. We show, among features, that...
Mycobacterium ulcerans , the causative agent of Buruli ulcer (BU) disease, is unique amongst human pathogens in its capacity to produce a lipid toxin called mycolactone. While previous studies have demonstrated that bacterially-released mycolactone diffuses beyond infection foci, spatiotemporal distribution remained largely unknown. Here, we used zebrafish model provide first global kinetic analysis mycolactone’s diffusion vivo and multicellular co-culture systems address critical question...
Mycobacterium tuberculosis (Mtb) hijacks host-derived fatty acids (FAs) to sustain its intracellular growth inside host cells. Here, we present a click-chemistry-based protocol assess FA import by Mtb in axenic culture or mouse macrophages. We describe the use of alkyne analogs natural FAs as an alternative structurally altered fluorescent derivatives hazardous radiolabeled FAs. also detail quantitative analyses uptake at single bacterial cell level flow cytometry and confocal fluorescence...
SUMMARY Depression is the leading cause of disability worldwide. Recent observations have revealed an association between mood disorders and alterations intestinal microbiota, but causality remains yet to be established. Here, using unpredictable chronic mild stress (UCMS) as a mouse model depression, we show that UCMS mice display phenotypic — characterized by altered gut microbiota composition, reduced adult hippocampal neurogenesis depressive-like behaviors which could transferred from...
ABSTRACT Successful control of Mycobacterium tuberculosis (Mtb) infection by macrophages relies on immunometabolic reprogramming, where the role fatty acids (FAs) remains poorly understood. Recent studies unraveled Mtb’s capacity to acquire saturated and monounsaturated FAs via Mce1 importer. However, upon activation produce polyunsaturated (PUFAs), mammal-specific mediating generation key immunomodulatory eicosanoids. Here, we asked whether de novo synthesis PUFAs is modulated in...