A5105875476- Gut microbiota and health
- Gastrointestinal motility and disorders
- Tryptophan and brain disorders
- Dental Radiography and Imaging
- Diet and metabolism studies
- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- Virology and Viral Diseases
- Cannabis and Cannabinoid Research
- Transgenic Plants and Applications
- IL-33, ST2, and ILC Pathways
- Mosquito-borne diseases and control
- Immunotherapy and Immune Responses
- Inflammatory Bowel Disease
- Oral microbiology and periodontitis research
- Asthma and respiratory diseases
- Viral Infections and Vectors
- Stress Responses and Cortisol
- HIV/AIDS oral health manifestations
- Endodontics and Root Canal Treatments
- Monoclonal and Polyclonal Antibodies Research
- Infant Health and Development
- Biological and pharmacological studies of plants
- Clostridium difficile and Clostridium perfringens research
- Cytomegalovirus and herpesvirus research
Enterome (France)
2021-2025
Institut Pasteur
2014-2022
Inserm
2011-2022
Université Paris Cité
2022
Immunité et Cancer
2017-2020
Université de franche-comté
2019
Hôpital Albert-Chenevier
2018
Centre National de la Recherche Scientifique
2011
Centre de Physiopathologie de Toulouse-Purpan
2011
Université de Toulouse
2011
Abstract Depression is the leading cause of disability worldwide. Recent observations have revealed an association between mood disorders and alterations intestinal microbiota. Here, using unpredictable chronic mild stress (UCMS) as a mouse model depression, we show that UCMS mice display phenotypic alterations, which could be transferred from donors to naïve recipient by fecal microbiota transplantation. The cellular behavioral observed in were accompanied decrease endocannabinoid (eCB)...
Gut bacteria influence brain functions and metabolism. We investigated whether this can be mediated by direct sensing of bacterial cell wall components neurons. In mice, we found that peptidoglycan plays a major role in mediating gut-brain communication via the Nod2 receptor. Peptidoglycan-derived muropeptides reach alter activity subset neurons express Nod2. Activation hypothalamic inhibitory is essential for proper appetite body temperature control, primarily females. This study identifies...
Major depressive disorders (MDDs) constitute a leading cause of disability worldwide and current pharmacological treatments are partially effective. The gut microbiota (GM) has recently emerged as target therapeutic interest for MDDs. In this study, we transfer GM from mice that sustained unpredictable chronic mild stress (UCMS) to healthy recipient mice. fecal induces despair-like behavior, decreases neurogenesis in the hippocampus (HpC), impairs antidepressant neurogenic effects standard...
Following infection of the central nervous system (CNS), immune is faced with challenge eliminating pathogen without causing significant damage to neurons, which have limited capacities renewal. In particular, it was thought that neurons were protected from direct attack by cytotoxic T lymphocytes (CTL) because they do not express major histocompatibility class I (MHC I) molecules, at least steady state. To date, most our current knowledge on specifics neuron-CTL interaction based studies...
Abstract Background An Escherichia coli ( E. ) pathotype with invasive properties, first reported by Darfeuille-Michaud and termed adherent-invasive (AIEC), was shown to be prevalent in up half the individuals Crohn’s Disease (CD), suggesting that these bacteria could involved pathophysiology of CD. Among genes related AIEC pathogenicity, fim has potential generate an inflammatory reaction from intestinal epithelial cells macrophages, as it interacts TLR4, inducing production cytokines...
Expression of FimH adhesin by invasive Escherichia coli in the gastrointestinal tract patients with Crohn's disease (CD) facilitates binding to epithelial glycoproteins and release pro-inflammatory cytokines. Sibofimloc is a first-in-class blocker that showed little systemic absorption healthy volunteers. The current study evaluated absorption, safety, effect on inflammatory biomarkers sibofimloc CD.This was an open-label, multicenter phase 1b adults active CD. In part 1, two received single...
Molecular mimicry between commensal bacterial antigens and tumor-associated (TAAs) has shown potential in enhancing antitumor immune responses. This study leveraged this concept using antigens, termed OncoMimics, to induce TAA-derived peptide (TAAp)-specific cross-reactive cytotoxic T cells improve the efficacy of peptide-based immunotherapies. The discovery OncoMimics primarily relied on a bioinformatics approach identify bacteria-derived sequences mimicking TAAps. Several (OMP) candidates...
A xenogeneic collagen matrix recently has been suggested as an alternative to connective tissue graft for the treatment of gingival recession. The avoids second surgical site, and a consequence could decrease morbidity. This new was used in various clinical situations compared (CTG) split-mouth design case series. total 17 recessions were treated with coronally advanced flap, 9 CTG, 8 matrix. Mean recession reduction 2.00 mm CTG No significant statistical differences between techniques...
Abstract Peptide vaccines have emerged as a promising strategy for cancer immunotherapy, yet often lack of strong, specific and sustained immune responses against tumor antigens. To achieve robust response, the effective selection tumour antigens is crucial. While neoantigens trigger potent responses, their use suffers from patient specificity rarity in low-mutational tumors. Alternatively, immunogenic potential tumor-associated (TAAs) limited by central tolerance. Molecular mimicry T cell...
SUMMARY Depression is the leading cause of disability worldwide. Recent observations have revealed an association between mood disorders and alterations intestinal microbiota, but causality remains yet to be established. Here, using unpredictable chronic mild stress (UCMS) as a mouse model depression, we show that UCMS mice display phenotypic — characterized by altered gut microbiota composition, reduced adult hippocampal neurogenesis depressive-like behaviors which could transferred from...
Le microbiote intestinal est considere de plus en comme un partenaire symbiotique contribuant au bon etat sante general l’organisme. but la presente revue synthetiser les donnees actuelles sur therapeutiques potentielles qui pourraient etre proposees aux patients souffrant troubles psychiatriques associes a une dysbiose intestinale. Les approches metagenomiques, pleine expansion, permettent mieux apprehender complexite l’ecosysteme et son impact le developpement fonctionnement du systeme...
Major depressive disorders (MDD) constitute a leading cause of disability worldwide and current pharmacological treatments are partially effective with high relapse rates. The gut microbiota has recently emerged as potential target therapeutic interest for MDD, yet the precise mechanisms remain unknown. In present study, we transferred fecal from chronically stressed mice to non-stressed recipient mice. We found that chronic stress resulted in dysbiosis was transferable transmitted induced...
Le microbiote intestinal est considere de plus en comme un partenaire symbiotique contribuant au bon etat sante general l’organisme. Les approches metagenomiques, pleine expansion, permettent mieux apprehender la complexite l’ecosysteme et son impact sur le developpement fonctionnement du systeme nerveux central hote.Le but presente revue synthetiser les donnees actuelles d’une part l’association entre dysbiose declenchement ou l’entretien troubles psychiatriques.