A5048976914- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- HIV Research and Treatment
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- 3D Printing in Biomedical Research
- Transgenic Plants and Applications
- SARS-CoV-2 detection and testing
- Virus-based gene therapy research
- Cancer Immunotherapy and Biomarkers
- Cytomegalovirus and herpesvirus research
- Nanoplatforms for cancer theranostics
- Long-Term Effects of COVID-19
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Antimicrobial Peptides and Activities
- Hidradenitis Suppurativa and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Respiratory Support and Mechanisms
- Fungal Infections and Studies
- Viral gastroenteritis research and epidemiology
- Chemotherapy-related skin toxicity
Enterome (France)
2023-2025
Institut Pasteur
2021-2024
Université Paris Cité
2022-2024
Centre National de la Recherche Scientifique
2021-2023
Immunité et Cancer
2023
Institut Mondor de Recherche Biomédicale
2017-2021
Université Paris-Est Créteil
2019
Inserm
2017-2019
Institut de Recherche Vaccinale
2017-2019
HIV elite controllers maintain a population of CD4 + T cells endowed with high avidity for Gag antigens and potent effector functions. How these HIV-specific avoid infection depletion upon encounter the virus remains incompletely understood. Ex vivo characterization single Gag-specific reveals an advanced Th1 differentiation pattern in controllers, except CCR5 marker, which is downregulated compared to specific treated patients. Accordingly, controller show decreased susceptibility...
Background The role of adaptive immune responses in long COVID remains poorly understood, with contrasting hypotheses suggesting either an insufficient antiviral response or excessive associated inflammatory damage. To address this issue, we set to characterize humoral and CD4+ T cell patients prior SARS-CoV-2 vaccination. Methods Long who were seropositive (LC+, n=28) seronegative (LC-, n=23) by spike ELISA assay recruited based on (i) initial infection documented PCR the conjunction three...
Predicting the immunogenicity of candidate vaccines in humans remains a challenge. To address this issue, we developed lymphoid organ-chip (LO chip) model based on microfluidic chip seeded with human PBMC at high density within 3D collagen matrix. Perfusion SARS-CoV-2 spike protein mimicked vaccine boost by inducing massive amplification spike-specific memory B cells, plasmablast differentiation, and antibody secretion. Features tissue, including formation activated CD4+ T cell/B cell...
To determine the contribution of skin DC subsets in regulation humoral immunity, we used a well-characterized antigen targeting system to limit availability and presentation certain skin-derived subsets. Here show that delivery foreign steady state Langerhans cells (LCs) cDC1s through same receptor (Langerin) led to, respectively, robust versus minimal-to-null immune response. LCs, unlike cDC1s, supported formation germinal center T follicular helper (GC-Tfh) dose-dependently then, likely...
Molecular mimicry between commensal bacterial antigens and tumor-associated (TAAs) has shown potential in enhancing antitumor immune responses. This study leveraged this concept using antigens, termed OncoMimics, to induce TAA-derived peptide (TAAp)-specific cross-reactive cytotoxic T cells improve the efficacy of peptide-based immunotherapies. The discovery OncoMimics primarily relied on a bioinformatics approach identify bacteria-derived sequences mimicking TAAps. Several (OMP) candidates...
A variety of signals influence the capacity dendritic cells (DCs) to mount potent antiviral cytotoxic T-cell (CTL) responses. In particular, innate immune sensing by pathogen recognition receptors, such as TLR and C-type lectines, influences DC biology affects their susceptibility HIV infection. Yet, whether combined effects PPRs triggering infection HIV-specific (HS) CTL responses remain enigmatic. Here, we dissect impact receptors on maturation, infection, quality HS activation....
The first SARS-CoV-2 variant that spread worldwide in early 2020 carried a D614G mutation the viral spike, making this protein more stable its cleaved form at surface of virions. Alpha and Delta variants, which late 2021, respectively, proved increasingly transmissible pathogenic compared to original strain.
ABSTRACT Predicting the immunogenicity of candidate vaccines in humans remains a challenge. To address this issue, we developed Lymphoid Organ-Chip (LO chip) model based on microfluidic chip seeded with human PBMC at high density within 3D collagen matrix. Perfusion SARS-CoV-2 Spike protein mimicked vaccine boost by inducing massive amplification Spike-specific memory B cells, plasmablast differentiation, and antibody secretion. Features lymphoid tissue, including formation activated CD4+ T...
The main avenue for the development of an HIV-1 vaccine remains induction protective antibodies. A rationale approach is to target antigen specific receptors on dendritic cells (DC) via fused monoclonal antibodies (mAb). In mouse and non-human primate models, targeting skin Langerhans (LC) with anti-Langerin mAbs Gag drives antigen-specific humoral responses. these immunization strategies in humans requires a better understanding early immune events driven by human LC. We therefore produced...
Abstract Peptide vaccines have emerged as a promising strategy for cancer immunotherapy, yet often lack of strong, specific and sustained immune responses against tumor antigens. To achieve robust response, the effective selection tumour antigens is crucial. While neoantigens trigger potent responses, their use suffers from patient specificity rarity in low-mutational tumors. Alternatively, immunogenic potential tumor-associated (TAAs) limited by central tolerance. Molecular mimicry T cell...
ABSTRACT SARS-CoV-2 remained genetically stable during the first three months of pandemic, before acquiring a D614G spike mutation that rapidly spread worldwide, and then generating successive waves viral variants with increasingly high transmissibility. We set out to evaluate possible epistatic interactions between early occurring more recently emerged cleavage site mutations present in Alpha, Delta, Omicron concern. The P681H/R at S1/S2 increased processing fusogenicity but limited its...
<h3>Background</h3> EOADR1–19/SPENCER study is a phase 1/2 trial of EO2401, evaluating the combination EO2401 with nivolumab, for treatment patients locally advanced or metastatic adrenocortical carcinoma (ACC) malignant pheochromocytoma/paraganglioma (MPP). novel immunotherapy designed to activate memory T cells specific gut microbiota derived peptides crossreacting tumor-associated antigens (TAAs). comprises three HLA-A2 restricted from commensal proteins (EO2316, EO2317 and EO2318),...
<h3>Background</h3> Efficacy demonstration of a unique peptide-based immunotherapy as potent approach for cancer treatment. This strategy relies on the activation commensal-specific T cells which cross-react against peptides derived from Tumor-Associated Antigens (TAAps) found in various solid tumors, including glioblastoma, adrenocortical carcinoma and colorectal cancer. The same is also used to target lineage-specific markers hematologic cancers such B cell malignancies. <h3>Methods</h3>...