A5101409299- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cystic Fibrosis Research Advances
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sarcoidosis and Beryllium Toxicity Research
- Asthma and respiratory diseases
- Blood Coagulation and Thrombosis Mechanisms
- Pulmonary Hypertension Research and Treatments
- Skin Protection and Aging
- Peptidase Inhibition and Analysis
- Hemophilia Treatment and Research
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Health and Medical Research Impacts
- Medical Imaging and Pathology Studies
- Systemic Sclerosis and Related Diseases
- Pediatric health and respiratory diseases
- Grief, Bereavement, and Mental Health
- Protein Hydrolysis and Bioactive Peptides
- Immune Response and Inflammation
- Tracheal and airway disorders
- Enzyme Production and Characterization
Quinnipiac University
2024
St. Vincent's Medical Center
2024
Walgreens Boots Alliance (United Kingdom)
2013-2021
Northwestern University
2019
University of Sudbury
2019
The Evergreen State College
2019
Laurentian University
2019
Towson University
2019
University of Washington
2019
University of Michigan–Ann Arbor
2019
The aim of this study was to examine the hypothesis that alveolar macrophages represent a significant source matrix-degrading proteinases in emphysematous lung. Macrophages from bronchoalveolar lavage fluid 10 patients with emphysema and normal volunteers were maintained vitro for 24 h assessed semiquantitatively mRNA transcript levels matrix metalloproteinases (MMPs) gelatinases A B, macrophage metalloelastase (MME), interstitial collagenase. Release these MMPs into culture medium secretion...
Matrix degradation in emphysema has long been attributed to the action of neutrophil elastase (NE). More recently a role for other proteases, particularly matrix metalloproteinases (MMPs), pathogenesis this disease proposed. To date, however, presence MMPs lungs patients with not demonstrated.Samples bronchoalveolar lavage (BAL) fluid from 10 and control subjects matched sex current smoking status were assessed collagenase, gelatinase, NE activity. Pulmonary function tests computed...
Sunlight contains ultraviolet (UV)A and UVB radiation. is essential for vitamin D synthesis but the main cause of sunburn skin cancer. Sunscreen use advocated to reduce sun's adverse effects may compromise status. To assess ability two intervention sunscreens inhibit during a week‐long sun holiday. The impact on status was studied 1‐week holiday in Tenerife (28° N). Comparisons were made between formulations, each with protection factor (SPF) 15. UVA‐protection (PF) low one case high other....
The purpose of this study was to examine the role interstitial collagenases, members family matrix metalloproteinases, in development pulmonary fibrosis. activity, levels and molecular forms collagenases (matrix metalloproteinases (MMP)-1, -8 -13), gelatinase B (MMP-9) its main endogenous inhibitor, tissue inhibitor metalloproteinase-1 (TIMP-1) were assessed bronchoalveolar lavage fluid (BALF) from patients with idiopathic fibrosis (IPF) sarcoidosis varying degrees parenchymal involvement....
SCCM Pediatric Critical Care Medicine Explorations
Genetic factors play a role in chronic obstructive pulmonary disease (COPD) but are poorly understood. A number of candidate genes have been proposed on the basis pathogenesis COPD. These include matrix metalloproteinase (MMP) which tissue remodelling and fit with protease - antiprotease imbalance theory for cause Previous genetic studies MMPs COPD had inadequate coverage genes, reported conflicting associations both single nucleotide polymorphisms (SNPs) SNP haplotypes, plausibly due to...
Nitric oxide (NO) can be detected in exhaled gas human subjects. It is produced by nitric synthase (NOS) and rapidly metabolized to nitrite nitrate (NO2/NO3). Exhaled NO reported elevated patients with asthma, bronchiectasis, or upper respiratory tract infection. Recent reports have shown no increase of stable cystic fibrosis (CF). We hypothesized that NOS activity increased acute pulmonary exacerbation CF. therefore measured sputum NO2/NO3 three subject categories: CF, healthy control Mean...
There has been considerable disagreement about the prognostic value of bronchoalveolar lavage lymphocyte measurements in patients with sarcoidosis. This study looks at influence type disease presentation and time since onset symptoms on fluid profiles 99 studied their initial diagnosis. Patients who had an acute inflammatory erythema nodosum (n = 32) or uveitis 17) almost invariably high T helper:suppressor (TH:TS) ratios (mean 10.1, 95% confidence interval 7.7-12.5) a higher proportion...
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Macrophage migration inhibitory factor (MIF) is a key proinflammatory mediator. It contributes toward an exaggerated gram-negative inflammatory response via its ability to induce Toll-like receptor-4 expression. Studies have shown that MIF knockout mice less aggressive Pseudomonas infection (compared with wild-type).To assess whether novel functional polymorphism was associated clinical prognosis in patient cohort chronic infection, namely cystic fibrosis (CF).Collected genomic DNA analyzed...
The potential role of neutrophil elastase in exacerbating pulmonary infection and tissue damage cystic fibrosis (CF) has led to proposals for treatment lung disease CF with the inhibitor, α1-proteinase inhibitor (α1PI). Reports that α1PI is inactivated suggest effectiveness therapy depends on quantity present extent inactivation, both which are expected vary severity. In this study we assessed elastase-α1PI profile sputum plasma from patients various degrees involvement. Levels active...
Although neutrophil migration from the systemic circulation involves beta2- (or CD18) integrin family, existence of an alternative, CD18-independent route extravasation to tissues has been demonstrated in animal models. The molecular interactions involved this alternative migratory have not yet characterized. objective study was assess CD18-dependency across human endothelial cells organ known support migration, lung, with a view establishing vitro model facilitate migration. Neutrophil...
Chronic obstructive pulmonary disease (COPD) is a major cause of mortality and morbidity worldwide. While cigarette smoking COPD, only 15% smokers develop the disease, indicating genetic influences. The most widely recognized candidate gene in COPD SERPINA1, although it has been suggested that SERPINA3 may also play role. To detect cryptic variants might contribute to we identified 15 SNP haplotype tags from high-density maps two genes evaluated these SNPs largest case-control study...
Objective: Prolonged hypercapnia is commonly encountered during the treatment of acute respiratory distress syndrome and failure attributable to other causes with protective ventilation strategies. In these circumstances, compensatory renal buffering returns pH normal establishing a condition buffered hypercapnia. It also common intensive care practice correct more rapidly using bicarbonate infusions. Although it well-established that hypercapnic acidosis has potent anti-inflammatory...
Genetic factors are known to contribute COPD susceptibility and these not fully understood. Conflicting results have been reported for many genetic studies of candidate genes based on their role in the disease. Genome-wide association combination with expression profiling identified a number new candidates including IREB2. A meta-analysis has implicated transforming growth factor beta-1 (TGFbeta1) as contributor disease susceptibility.We examined previously associations both collection 1017...
Sun protection factor (SPF) is assessed with sunscreen applied at 2 mg cm-2 . People typically apply around 0·8 and use daily for holidays. Such results in erythema, which a risk skin cancer.To determine (i) whether typical resulted epidermal DNA damage photoimmunosuppression during sunny holiday, (ii) optimal inhibited erythema (iii) biomarker laboratory study.Holidaymakers (n = 22) spent week Tenerife (very high ultraviolet index) using their own sunscreens without instruction (typical...
The reported prevalence of interstitial lung disease in patients with rheumatoid arthritis has varied from 10% to 50%, yet less than 5% develop severe fibrosing disease. This suggests that subclinical may not always presage progressive Bronchoalveolar lavage fluid and either clinically evident or was examined for the presence factors a putative role development fibrosis. Patients were identified by prospective radiographic function screening 93 arthritis. Fourteen this manner an association...
Bronchoalveolar lavage fluid from 43 patients with biopsy proved sarcoidosis and 10 control subjects were assayed for fibronectin collagenase activity. Fibronectin was significantly increased in the group found to be positively correlated angiotensin converting enzyme activity, protein concentration, percentage of T cells helper:suppressor ratios fluid. Increased bronchoalveolar not related functional or radiographic indices interstitial disease did identify subsequently requiring treatment....
The neutrophil-dominated inflammation of the lung in cystic fibrosis (CF) has traditionally been seen as a physiological response to continuous opportunistic infection. Recent studies suggest, however, that regulation inflammatory itself may be altered CF. Neutrophil migration from bloodstream involves alterations surface expression adhesion molecules L-selectin and Mac-1 (CD11b/CD18). aim this study was assess neutrophil molecule responsiveness Neutrophils chronic (n = 16) acutely infected...