A5028439145- Hemodynamic Monitoring and Therapy
- Neonatal Respiratory Health Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Optical Imaging and Spectroscopy Techniques
- Neonatal and fetal brain pathology
- Non-Invasive Vital Sign Monitoring
- Mechanical Circulatory Support Devices
- Central Venous Catheters and Hemodialysis
- Congenital Heart Disease Studies
- Ultrasound in Clinical Applications
- Neonatal skin health care
- Neonatal Health and Biochemistry
- Cerebrospinal fluid and hydrocephalus
- Pediatric Pain Management Techniques
- Respiratory Support and Mechanisms
- Infant Health and Development
- Cardiac Arrest and Resuscitation
- Anesthesia and Neurotoxicity Research
- Cardiovascular Conditions and Treatments
- Infant Development and Preterm Care
- Blood Coagulation and Thrombosis Mechanisms
- Neuroscience of respiration and sleep
- Anesthesia and Sedative Agents
- Infant Nutrition and Health
- Spectroscopy Techniques in Biomedical and Chemical Research
Radboud University Nijmegen
2015-2024
Radboud University Medical Center
2015-2024
Amalia Kinderziekenhuis
2016-2020
Research Network (United States)
2020
University of Florida
2019
Columbus Oncology and Hematology Associates
2019
University Medical Center
2001-2018
University Medical Center Utrecht
2013
Transonic Systems (United States)
2010
University Hospital and Clinics
2001
Objective To compare a low versus higher threshold for intervention in preterm infants with posthaemorrhagic ventricular dilatation. Design Multicentre randomised controlled trial ( ISRCTN43171322 ). Setting 14 neonatal intensive care units six countries. Patients 126 ≤34 weeks gestation dilatation after grade III–IV haemorrhage were to (LT) (ventricular index (VI) >p97 and anterior horn width (AHW) >6 mm) or (HT) (VI>p97+4 mm AHW >10 mm). Intervention Cerebrospinal fluid tapping...
SIDS and ALTE are different entities that somehow show some similarities. Both constitute heterogeneous conditions. The Netherlands is a low-incidence country for SIDS. To study whether the same would hold ALTE, we studied incidence, etiology, current treatment of in Netherlands. Using Dutch Pediatric Surveillance Unit, pediatricians working second- third-level hospitals were asked to report any case presented their hospital from January 2002 2003. A questionnaire was subsequently sent...
Research regarding the etiology of birth defects and childhood cancer is essential to develop preventive measures, but often requires large study populations. Therefore, we established AGORA data- biobank in Netherlands. In this study, describe its rationale, design, ongoing data collection.Children diagnosed with and/or treated for a structural defect or their parents are invited participate biobank. Controls recruited through random sampling from municipal registries. The receive...
<i>Background:</i> Midazolam sedation and morphine analgesia are commonly used in ventilated premature infants. <i>Objectives:</i> To evaluate the effects of midazolam versus infusion on cerebral oxygenation hemodynamics <i>Methods:</i> 11 patients (GA 26.6–33.0 weeks, BW 780–2,335 g) were sedated with (loading dose 0.2 mg/kg, maintenance mg/kg/h) 10 26.4–33.3 842–1,955 0.05 0.01 mg/kg/h). Changes oxyhemoglobin...
Aim Periventricular haemorrhagic infarction (PVHI) is a complication of preterm birth associated with cardiorespiratory instability. To date, the role thrombophilia as possible additional risk factor in infants atypical timing and presentation PVHI has not been investigated. Method This was retrospective cohort study who developed an either antenatal onset or late postnatal course absence preceding sudden deterioration their clinical condition. In mutation analysis V Leiden (G1691A),...
Evidence for drug use in newborns is sparse, which may cause large differences prescriptions. We aimed to investigate the between neonatal intensive care units (NICUs) Netherlands currently prescribed drugs.This multicentre study included neonates admitted during 12 months four different NICUs. Drugs were classified accordance with Anatomical Therapeutic Chemical (ATC) classification system and assessed on/off-label status relation age. The treatment protocols common indications compared:...
arnts i.j.j., heijnen j.a., wilbers h.t.m., van der wilt g.j., groenewoud j.m.m. & liem k.d. (2011) Effectiveness of heparin solution versus normal saline in maintaining patency intravenous locks neonates: a double blind randomized controlled study. Journal Advanced Nursing67(12), 2677–2685. Abstract Aim. The aim this study was to evaluate the effect as flush for peripheral neonates and investigate whether other variables influence longevity locks. Background. Heparin is usually used regular...
Background Fentanyl is frequently used off-label in preterm newborns. Due to very limited pharmacokinetic and pharmacodynamic data, fentanyl dosing mostly based on bodyweight. This study describes the maturation of pharmacokinetics neonates born before 32 weeks gestation. Methods 442 plasma samples from 98 (median gestational age: 26.9 (range 23.9–31.9) weeks, postnatal 3 0–68) days, bodyweight 1.00 0.39–2.37) kg) were collected an opportunistic trial levels determined. NONMEM V.7.3 was...
Recirculation is a limiting factor for oxygen delivery in double lumen catheter veno-venous extracorporeal membrane oxygenation (DLVV-ECMO). This study compares three different methods the determination of recirculation fraction during ECMO at flow rates 150, 125, 100, 75, and 50 ml/kg.min nine lambs: (1) an ultrasound dilution method, which change velocity blood after injection saline bolus as marker used recirculation; (2) SvO2 method using real mixed venous saturation, gold standard,...
To assess agreement between a new method of cardiac output monitoring, using ultrasound dilution technology and transit time-based measurement pulmonary blood flow in piglet model.Prospective, experimental juvenile animal study.Animal laboratory university hospital.Nine random-bred piglets.After the animals received general anesthesia, we placed intravascular arterial central venous catheters with tip positioned abdominal aorta right atrium, respectively. The were connected to monitor. An...