A5033676105- Health Systems, Economic Evaluations, Quality of Life
- Healthcare cost, quality, practices
- Pharmaceutical Economics and Policy
- Ear Surgery and Otitis Media
- Hormonal Regulation and Hypertension
- Health Policy Implementation Science
- Delphi Technique in Research
- Dutch Social and Cultural Studies
- Cerebral Palsy and Movement Disorders
- Adrenal and Paraganglionic Tumors
- Statistical Methods in Clinical Trials
- Adrenal Hormones and Disorders
- Healthcare Policy and Management
- Blood Pressure and Hypertension Studies
- Hearing Loss and Rehabilitation
- Biomedical Ethics and Regulation
- Respiratory and Cough-Related Research
- Retinal Diseases and Treatments
- Meta-analysis and systematic reviews
- Tracheal and airway disorders
- Health Promotion and Cardiovascular Prevention
- Evaluation and Performance Assessment
- Ethics in medical practice
- Hearing Impairment and Communication
- Clinical practice guidelines implementation
Radboud University Nijmegen
2015-2024
Radboud University Medical Center
2015-2024
Eindhoven University of Technology
2022
Radboud Institute for Molecular Life Sciences
2022
University Medical Center
2001-2021
University of Groningen
2014-2021
University Medical Center Groningen
2014-2021
University of Rochester Medical Center
2021
University of Kansas Medical Center
2021
Amsterdam Neuroscience
2021
To study the effect of folates on discontinuation methotrexate (MTX) as single-drug antirheumatic treatment due to toxicity, determine which type adverse events are reduced, effects efficacy MTX, and compare folic with folinic acid supplementation in a 48-week, randomized, double-blind, placebo-controlled trial.Patients active RA (n = 434) were randomly assigned receive MTX plus either placebo, (1 mg/day), or (2.5 mg/week). The initial dosage was 7.5 mg/week; increases allowed up maximum 25...
PurposeImplementation of novel genetic diagnostic tests is generally driven by technological advances because they promise shorter turnaround times and/or higher yields. Other aspects, including impact on clinical management or cost-effectiveness, are often not assessed in detail prior to implementation.MethodsWe studied the utility whole-exome sequencing (WES) complex pediatric neurology terms yield and costs. We analyzed 150 patients (and their parents) presenting with neurological...
The aim of this paper is to propose a new model sustainable employability based on the capability approach, encompassing complexity contemporary work, and placing particular emphasis work-related values.Having evaluated existing conceptual models health, employability, we concluded that prevailing lack an important values. Amartya Sen's approach (CA) provides framework incorporates focus values reflects employability.We developed CA. This can be used as starting point for developing...
Abstract Background Reconstruction of giant midline abdominal wall hernias is difficult, and no data are available to decide which technique should be used. It was the aim this study compare “components separation technique” (CST) versus prosthetic repair with e‐PTFE patch (PR). Method Patients were randomized for CST or PR. underwent operation following standard procedures. Postoperative morbidity scored on a form, patients followed 36 months after recurrent hernia. Results Between November...
The main objective of this study was to compare the clinical outcome participants treated by simple decompression (SD) ulnar nerve versus anterior subcutaneous transposition (AST).A prospective randomized controlled performed. Three hundred forty were referred our institution between March 1999 and July 2002. One fifty-two patients met inclusion criteria into two surgical groups: 75 assigned SD, 77 AST. Participants followed for 1 year after surgery. measure surgery.An excellent or good...
To determine the best approach for live donor nephrectomy to minimise discomfort and provide good graft function.Single blind, randomised controlled trial.Two university medical centres, Netherlands.100 living kidney donors.Participants were randomly assigned either laparoscopic or mini incision muscle splitting open nephrectomy.The primary outcome was physical fatigue using multidimensional inventory 20 (MFI-20). Secondary outcomes function SF-36, hospital stay after surgery, pain,...
To study the effectiveness of ventilation tubes on language development in infants with persistent otitis media effusion (OME). All existing studies addressed children 3 years age or older. Currently, OME is detected and treated at a younger age. Because critical relationship between age, hearing, development, we conducted effects 1 to 2 old OME.A multicenter, randomized, controlled trial (embedded cohort) treatment arms: 1) (VT group; n = 93); 2) period watchful waiting (WW 94). Hearing...
The substantial technological advancements in next-generation sequencing (NGS), combined with dropping costs, have allowed for a swift diffusion of NGS applications clinical settings. Although several commercial parties report to broken the $1000 barrier an entire human genome, valid cost overview is currently lacking. This study provides complete, transparent and up-to-date total costs different applications.Cost calculations targeted gene panels (TGP), whole exome (WES) genome (WGS) were...
The complexity associated with how interventions result-or fail to result-in outcomes and context matters is increasingly recognised. Logic models provide an important tool for handling complexity, contrasting uses in programme evaluation evidence synthesis. To reconcile these, we developed approach that combines the strengths of both traditions, propose a taxonomy logic models, guidance on choose between approaches types systematic reviews health technology assessments (HTA). distinguishes...
Abstract Context In primary aldosteronism (PA), two subtypes are distinguished: aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia (BAH). general, these treated by adrenalectomy (ADX) mineralocorticoid receptor antagonists (MRA), respectively. Objective To compare the effects of surgical treatment medical on quality life (QoL). Design Post hoc comparative effectiveness study within Subtyping Primary Aldosteronism: A Randomized Trial Comparing Adrenal Vein Sampling Computed...
In rare diseases it is difficult to achieve high-quality evidence of treatment efficacy because small cohorts and clinical heterogeneity. With emerging treatments for diseases, innovative trial designs are needed.To investigate the effectiveness mexiletine in nondystrophic myotonia using an aggregated N-of-1 trials design compare results between this a previously conducted RCT.A series aggregated, double-blind, randomized, placebo-controlled N-of-1-trials, performed single academic referral...