We examined prenatal and perinatal factors predicting cerebral palsy, using multivariate analysis to investigate which were most important the proportion of cases for they accounted. Maternal mental retardation, birth weight below 2001 g, fetal malformation among leading predictors. Breech presentation was also a predictor, but breech delivery not. A third children with palsy who had presentations major noncerebral malformation. Among 189 40 (21 percent) at least one three clinical markers...

We examined the frequency of development afebrile seizures in 1706 children who had experienced at least one febrile seizure and were followed to age seven years. Epilepsy developed by years 20 per 1000 (2 cent), another 10 that did not meet our definition epilepsy. In whose neurologic or developmental status was suspect abnormal before any first complex (longer than 15 minutes, multiple focal) epilepsy a rate 18 times higher with no (92 vs. 5 1000; P less 0.001). largest group seizures,...

Febrile seizures occurred in 3.5% of white and 4.2% black children who were followed up a large prospectively defined cohort. The frequency adverse outcomes was examined this population risk factors identified. Among 1,706 with febrile seizures, no deaths or persistent motor deficits as sequelae seizures. Todd's paresis 0.4%. Risk identified for epilepsy after family history afebrile preexisting neurological abnormality, complicated initial seizure. Of the 60% had none these factors, 1%...

The National Institute of Neurological Disorders and Stroke the Office Rare sponsored a workshop on perinatal childhood stroke in Bethesda, Maryland, September 18 19, 2000. This was an international to bring together experts field stroke. Topics covered included epidemiology, animal models, risk factors, outcome prognosis, areas future research for infants children is important cause morbidity mortality emerging area clinical translational research. Currently, there no consensus...

Apgar scores were recorded at one and five minutes for approximately 49,000 infants, ten, 15, 20 babies who did not achieve a score of 8 or higher minutes. These children followed to the age 7 years. Low risk factors cerebral palsy, but 55% with later palsy had 10 minute, 73% scored Of 99 0 3 survived, 12 (12%) palsy; 11 also mentally retarded (in IQ < 50) half seizure disorders. Eight survived after having very low late have lesser significant disabilities. ten 80% free major...

Abstract We explored the association of inflammatory mediators and markers autoimmune coagulation disorders with cerebral palsy (CP), examinig 53 analytes in dried neonatal blood 31 children spastic CP, most born at term, 65 control children. Ultramicroanalysis was performed by recycling immunoaffinity chromatography coupled laser‐enhanced fluorescence chemiluminescence detection. Reactive antibodies to lupus anticoagulant, anticardiolipin, antithrombin III, translational product factor V...

To investigate whether in utero exposure to magnesium sulfate (MgSO4) was associated with a lower prevalence of cerebral palsy (CP) infants born weighing < 1500 g.Singleton g at birth (very low birthweight, VLBW) and surviving 3 years moderate or severe congenital CP were identified among 155,636 children 1983 through 1985 four California counties. VLBW compared randomly selected control survivors respect their mothers received MgSO4 prevent convulsions preeclampsia as tocolytic agent, other...

Phenobarbital is widely used in the treatment of children with febrile seizures, although there concern about possible behavioral and cognitive side effects. In 217 between 8 36 months age who had at least one seizure were heightened risk further we compared intelligence quotients (IQs) a group randomly assigned to daily doses phenobarbital (4 5 mg per kilogram body weight day) IQs placebo.

Electronic monitoring of the fetal heart rate is commonly performed, in part to detect hypoxia during delivery that may result brain injury. It not known whether specific abnormalities on electronic are related risk cerebral palsy.

Ischemic perinatal stroke is a disorder associated with significant long-term neurologic morbidity. With an estimated incidence of 1 in 2300 to 5000 births, more likely occur the period than at any time childhood. The ischemic ranks second only that strokes elderly population. Although well-recognized disorder, many aspects remain be studied. There no consensus on its terminology, definition, or classification. Several risk factors have been identified, but their precise roles causing are...

There has been little exploration of major biologic regulators cerebral development in autism. In archived neonatal blood children with autistic spectrum disorders (n = 69), mental retardation without autism 60), or palsy (CP, n 63) and control 54), we used recycling immunoaffinity chromatography to measure the neuropeptides substance P (SP), vasoactive intestinal peptide (VIP), pituitary adenylate cyclase-activating polypeptide (PACAP), calcitonin gene-related (CGRP), neurotrophins nerve...

A diagnosis of cerebral palsy was made for 229 one-year-old children enrolled in a large longitudinal study. Of these children, 118 were free motor handicap at the age 7 years. Mild early palsy, and monoparetic, ataxic/dyskinetic, diplegic forms disorder, resolved with high frequency. Normalization signs observed more frequently black than white children. However, 13% 25% whose mentally retarded (IQ below 70) years age. Nonfebrile seizures, abnormalities speech articulation extraocular...

Abstract The primary analysis of a randomized clinical trial should compare patients in their randomly assigned treatment groups (intention to treat analysis). When substantial number subjects fail take prescribed medication or are switched different study medication, it is tempting consider comparisons using only those with as actually received rather than prescribed. There several arguments against this approach: the prognostic balance brought about by randomization likely be disturbed;...

Signs of presumed hypoxia/asphyxia the fetus are not uncommon and can be detected during labor, in delivery room, early neonatal period. Virtually no single sign or symptom has sufficient correlation to enable prediction later cerebral palsy with a reasonable degree medical certainty. To attribute prior asphyxia certainty, there must evidence that substantial hypoxic injury occurred sequence events ensued which would prove clinical impact insult. Few cases meet these criteria.

This Sounding Board article reviews the available evidence and concludes that — at least present cerebral palsy is not preventable in vast majority of cases.

A large prospective study investigated prenatal and perinatal antecedents of chronic motor dysfunction (cerebral palsy [CP]), evaluating approximately 400 characteristics the mothers, pregnancies, or deliveries. In addition to confirming some, but not all, classic risk factors for CP, this observed relatively increases in CP rate association with maternal mental retardation, seizure disorders, hyperthyroidism, administration thyroid hormone estrogen pregnancy. Some were predictive only...

To reassess the relations between postulated risk factors and seizure recurrence after a first febrile (FS), individual data from five follow-up studies that used similar definitions of FSs were pooled reanalyzed. The frequent recurrent seizures occurrence complex in previously healthy, untreated children was studied. Seizure hazard described as function child's attained age. influence various on assessed, with control for other factors. Of total 2496 1410 episodes seizures, 32% had one, 15%...

Signs of neonatal neurologic dysfunction, recorded in approximately 40,000 infants, were evaluated prospectively for their ability to predict later motor handicap. Tenfold 33-fold increases risk cerebral palsy (CP) observed surviving children with any one the following characteristics: birth weight less than 2,000 gm, head circumference more 3 SD above or below mean, five minute Apgar score less, diminished activity cry lasting day, thermal instability, need gavage feeding, hypotonia...

In a prospective study, late obstetric complications were common, one or more occurring in 62% of 51,285 pregnancies. We examined these as risk factors for cerebral palsy (CP) nonfebrile seizure disorders. Certain associated with an increased rate CP, but babies over 2,500 g, the observed CP did not exceed 2% following any condition evaluated. For most conditions, was highest small subgroup children who had five-minute Apgar scores 3 less. Most g born after each complication achieved 7...