A5047041488- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Thermal Regulation in Medicine
- Cardiac Arrest and Resuscitation
- Infant Development and Preterm Care
- Traumatic Brain Injury and Neurovascular Disturbances
- Preterm Birth and Chorioamnionitis
- Anesthesia and Neurotoxicity Research
- EEG and Brain-Computer Interfaces
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Fetal and Pediatric Neurological Disorders
- Heart Rate Variability and Autonomic Control
- Growth Hormone and Insulin-like Growth Factors
- Diabetes Management and Research
- Infectious Encephalopathies and Encephalitis
- Connexins and lens biology
- Diabetes and associated disorders
- Congenital Heart Disease Studies
- Restraint-Related Deaths
- Pancreatic function and diabetes
- Mitochondrial Function and Pathology
- Genetic factors in colorectal cancer
- Non-Invasive Vital Sign Monitoring
University of Auckland
2016-2025
Anna Needs Neuroblastoma Answers
2024
University of South Alabama
2024
Hudson Institute of Medical Research
2023
Monash University
2023
Starship Children's Health
2012-2023
Auckland District Health Board
2012-2022
Yorkshire Ambulance Service NHS Trust
2018
Brown University
2016
Okayama University
2016
Aims. To determine the practicality and safety of head cooling with mild or minimal systemic hypothermia in term neonates moderate to severe hypoxic-ischemic encephalopathy. Methods. Study group infants ≥37 weeks' gestation, who had an umbilical artery pH ≤7.09 Apgars ≤6 at 5 minutes, plus evidence Infants major congenital abnormalities were excluded. Trial Design. randomized either no (controls; rectal temperature = 37.0 ± 0.2°C,n 10) sequentially, (rectal 36.3 6) 35.7 0.2°C, n 6). Head was...
Hypothermia has been proposed as a neuroprotective strategy. However, short-term cooling after hypoxia-ischemia is effective only if started immediately during resuscitation. The aim of this study was to determine whether prolonged head cooling, delayed into the late postinsult period, improves outcome from severe ischemia. Unanesthetized near term fetal sheep were subject 30 min cerebral 90 later they randomized either (n = 9) or sham 7) for 72 h. Intrauterine induced by coil around head,...
OBJECTIVE. The goal of this study was to evaluate the role factors that may determine efficacy treatment with delayed head cooling and mild systemic hypothermia for neonatal encephalopathy. METHODS. A total 218 term infants moderate severe encephalopathy plus abnormal amplitude-integrated electroencephalographic recordings, assigned randomly 72 hours, starting within 6 hours after birth (with rectal temperature maintained at 34.5 ± 0.5°C), or conventional care, were studied. Death disability...
Objective. Cerebral hypothermia has been shown to reduce damage from experimental hy-poxia-ischemia if started shortly after reperfusion. However, in the newborn infant it may not be feasible determine prognosis so soon exposure asphyxia. The aim of this study was whether head cooling, delayed until before onset postasphyxial seizure activity, is neuroprotective. Methods. Unanesthetized near-term fetal sheep utero were subjected 30 minutes cerebral ischemia. Later, at 5.5 hours, they...
GH therapy requires daily injections over many years and compliance can be difficult to sustain. As growth hormone (GH) is expensive, non-compliance likely lead suboptimal growth, at considerable cost. Thus, we aimed assess the rate of children adolescents with treatment in New Zealand.This was a national survey compliance, which all receiving government-funded for four-month interval were included. Compliance defined as ≥ 85% adherence (no more than one missed dose week on average)...
Abstract The role of seizures occurring with perinatal hypoxic‐ischemic encephalopathies is unclear. We examined the relationships between time course parasagittal electroencephalographic (EEG) activity and pathological outcome following transient cerebral ischemia, which was induced in 33 chronically instrumented fetal sheep by occluding carotid arteries after ligation vertebral‐carotid anastomoses. EEG quantified real‐time spectral analysis. Histological assessed 72 hours later. After 10...
Objective. To assess the safety of selective head cooling in birth-asphyxiated term newborn infants while maintaining rectal temperature at 35.0°C or 34.5°C. Methods. Twenty-six with Apgar ≤6 5 minutes cord/first arterial pH <7.1, plus evidence encephalopathy, were studied. After parental consent had been obtained, 13 received maintained 6 and 34.5°C 7 infants. The remaining normothermic. Cooling was achieved by circulating water 10°C through a cap placed around head. Rectal,...
The role of edema in the pathogenesis hypoxic-ischemic injury immature brain is controversial. We studied 15 chronically instrumented fetal sheep following transient cerebral ischemia, to estimate changes extracellular space using an impedance technique, quantify electroencephalogram with real-time spectral analysis, and assess histologic outcome 3 days after insult. These measurements were made parasagittal cortex. There was a rapid loss from 5 +/- 2 minutes onset ischemia. Following 10...