A5031302533- Neonatal and fetal brain pathology
- Vagus Nerve Stimulation Research
- Infant Development and Preterm Care
- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- EEG and Brain-Computer Interfaces
- Cerebral Palsy and Movement Disorders
- Advanced MRI Techniques and Applications
- Child Nutrition and Feeding Issues
- Neuroscience and Neural Engineering
- Botulinum Toxin and Related Neurological Disorders
- Infant Health and Development
- Thermal Regulation in Medicine
- Preterm Birth and Chorioamnionitis
- Obstructive Sleep Apnea Research
- Pregnancy and preeclampsia studies
- Prenatal Substance Exposure Effects
- Cardiac Arrhythmias and Treatments
- Anesthesia and Neurotoxicity Research
- Advanced Neuroimaging Techniques and Applications
- Heart Rate Variability and Autonomic Control
- Infectious Encephalopathies and Encephalitis
- Children's Physical and Motor Development
- Epilepsy research and treatment
- Neurological disorders and treatments
Medical University of South Carolina
2015-2024
Laboratoire d’Imagerie Biomédicale
2021
University of Charleston
2016-2018
Alstom (France)
2014
National Institutes of Health
2011
Inflammatory cytokines may mediate hypoxic-ischemic (HI) injury and offer insights into the severity of timing recovery. In our randomized, multicenter trial hypothermia, we analyzed temporal relationship serum cytokine levels in neonates with encephalopathy (HIE) neurodevelopmental outcome at 12 months. Serum were measured every hours for 4 days 28 hypothermic (H) 22 normothermic (N) HIE. Monocyte chemotactic protein-1 (MCP-1) interleukins (IL)-6, IL-8, IL-10 significantly higher H group....
Non-invasive vagus nerve stimulation (VNS) may be administered via a novel, emerging neuromodulatory technique known as transcutaneous auricular (taVNS). Unlike cervically-implanted VNS, taVNS is an inexpensive and non-surgical method used to modulate the system. appealing it allows for rapid translation of basic VNS research serves safe, inexpensive, portable neurostimulation system future treatment central peripheral disease. The background rationale described, along with electrical...
Objectives: To determine systemic hypothermia's effect on circulating immune cells and their corresponding chemokines after hypoxic ischemic encephalopathy in neonates. Design: In our randomized, controlled, multicenter trial of hypothermia neonatal encephalopathy, we measured total leukocyte subset serum chemokine levels over time both normothermia groups, as primary outcomes for safety. Setting: Neonatal ICUs participating a Neurological Disorders Stroke sponsored clinical therapeutic...
ObjectiveTo evaluate the clinical safety of antenatal and postnatal N-acetylcysteine (NAC) as a neuroprotective agent in maternal chorioamnionitis randomized, controlled, double-blinded trial.Study designTwenty-two mothers >24 weeks gestation presenting within 4 hours diagnosis were randomized with their 24 infants to NAC or saline treatment. Antenatal (100 mg/kg/dose) was given intravenously every 6 until delivery. Postnatally, (12.5-25 mg/kg/dose, n = 12) (n 12 for 5 doses. Doppler studies...
Neonates born premature or who suffer brain injury at birth often have oral feeding dysfunction and do not meet intake requirements needed for discharge. Low volumes result in extended stays the hospital (>2 months) can lead to surgical implant explant of a gastrostomy tube (G-tube). Prior work suggests pairing vagus nerve stimulation (VNS) with motor activity accelerates functional improvements after stroke, transcutaneous auricular VNS (taVNS) has emerged as promising noninvasive form VNS....
Persistent oxidative stress depletes reduced glutathione (GSH), an intracellular antioxidant and important determinant of CNS injury after hypoxia ischemia. We used standard, short echo time Stimulated Echo Acquisition Mode (STEAM) to detect GSH by magnetic resonance spectroscopy (MRS) in 24 term neonates with hypoxic-ischemic encephalopathy (HIE), on day life 5–6, rewarming from therapeutic hypothermia. MRS demonstrated reliable, consistent 1·64 ± 0·20 mM the basal ganglia immediately...
Approximately half of moderate to severely hypoxic-ischemic (HI) newborns do not respond hypothermia, the only proven neuroprotective treatment. N-acetylcysteine (NAC), an antioxidant and glutathione precursor, shows promise for neuroprotection in combination with mitigating post-HI neuroinflammation due oxidative stress. As mechanisms HI injury cell death differ males females, sex differences must be considered translational research neuroprotection. We assessed potential toxicity efficacy...
Non-invasive vagus nerve stimulation (VNS) may be administered via a novel, emerging neuromodulatory technique known as transcutaneous auricular (taVNS). Unlike cervically-implanted VNS, taVNS is an inexpensive and non-surgical method used to modulate the system. appealing it allows for rapid translation of basic VNS research serves safe, inexpensive, portable neurostimulation system future treatment central peripheral disease. The background rationale described, along with electrical...
Abstract Background Neonatal abstinence syndrome (NAS) is a significant problem. Opioid withdrawal induces oxidative stress and disrupts glutamate glutathione homeostasis. We hypothesized that N -acetylcysteine (NAC) administered during acute opioid in neonatal rats would decrease behaviors normalize CNS glutamate. Methods Osmotic minipumps with methadone (opioid dependent, OD) saline (Sham) were implanted into Sprague Dawley dams 7 days prior to delivery. Pups randomized receive either...
Studies have found that pairing vagus nerve stimulation (VNS) with motor activity accelerates cortical reorganization. This synchronous may enhance recovery.To develop and validate a motor-activated auricular (MAAVNS) system as potential neurorehabilitation tool.We created MAAVNS validated its function part of an ongoing clinical trial investigating whether taVNS-paired rehabilitation enhances oromotor learning. We compared 3 different EMG electrode configurations in neonates. The active...
Hypothermia treatment neuroprotects approximately 50% of neonates who present with moderate to severe hypoxic ischemic encephalopathy (HIE). N-acetylcysteine (NAC), a potent antioxidant, is neuroprotective in combination hypothermia neonatal hypoxia-ischemia (HI) female rats, but less protective males. Vitamin D neurosteroid, which may provide immunomodulation and improve outcomes for both sexes. We investigated the efficacy this drugs after HI, as well potential mechanisms vitamin effects...
Sex is an important determinant of neonatal outcomes and may have a significant role in the physiologic response to maternal chorioamnionitis. Our goal was determine cerebral blood flow (CBF) parameters by sex subsequent neurodevelopment healthy term infants exposed CBF Doppler ultrasound anterior middle (ACA, MCA) basilar arteries were analyzed for time-averaged maximum velocity (TAMX) corrected resistive index 52 control chorioamnionitis-exposed between 24 72 h after birth. Placental...
Maternal opioid use during pregnancy is a growing national problem and can lead to newborns developing neonatal withdrawal syndrome (NOWS) soon after birth. Recent data demonstrates that nearly every 15 min baby born in the United States suffering from NOWS. The primary treatment for NOWS replacement therapy, commonly oral morphine, which has neurotoxic effects on brain. There an urgent need non-opioid treatments Transcutaneous auricular neurostimulation (tAN), novel non-invasive form of...
In most cases of neonatal hypoxic-ischemic encephalopathy, the exact timing event is unknown, and we have few reliable biomarkers to precisely identify phase injury or recovery in an individual patient. However, it becoming increasingly clear that for neuroprotection neonates succeed, understanding important ascertain. addition, utero antecedents chronic hypoxia, hypoxic preconditioning, intrauterine infection, fetal gender may change expected time course injury. Neuroprotective...