A5046601280- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Neonatal and Maternal Infections
- Infant Development and Preterm Care
- Congenital Diaphragmatic Hernia Studies
- Pregnancy and preeclampsia studies
- Neuroscience of respiration and sleep
- Central Venous Catheters and Hemodialysis
- Infant Nutrition and Health
- Streptococcal Infections and Treatments
- Venous Thromboembolism Diagnosis and Management
- Thermal Regulation in Medicine
- Transplantation: Methods and Outcomes
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Nitric Oxide and Endothelin Effects
- Child and Adolescent Health
- Respiratory Support and Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Respiratory viral infections research
- Retinopathy of Prematurity Studies
- Maternal and Perinatal Health Interventions
- Airway Management and Intubation Techniques
Albany Medical Center Hospital
2013-2024
Royal National Orthopaedic Hospital
2024
University College London
2024
University Hospital Waterford
2017
American College of Surgeons
2016
New York State Department of Health
2015
Oregon Health & Science University
2000
Neurological Surgery
2000
Golisano Children's Hospital
1998
University of Florida
1996
In 2008, all 18 regional referral NICUs in New York state adopted central-line insertion and maintenance bundles agreed to use checklists monitor maintenance-bundle adherence report checklist use. We sought confirm whether adopting standardized using reduced central-line-associated bloodstream infections (CLABSI).This was a prospective cohort study that enrolled neonates with central line who were hospitalized any of NICUs. Each NICU reported CLABSI utilization data used χ(2) compare rates...
Exogenous pulmonary surfactants are administered into the trachea either to prevent respiratory distress syndrome in premature infants or treat it. In a randomized, multicenter trial, we compared results of surfactant therapy initiated as prophylaxis with rescue surfactant.
Inflammatory cytokines may mediate hypoxic-ischemic (HI) injury and offer insights into the severity of timing recovery. In our randomized, multicenter trial hypothermia, we analyzed temporal relationship serum cytokine levels in neonates with encephalopathy (HIE) neurodevelopmental outcome at 12 months. Serum were measured every hours for 4 days 28 hypothermic (H) 22 normothermic (N) HIE. Monocyte chemotactic protein-1 (MCP-1) interleukins (IL)-6, IL-8, IL-10 significantly higher H group....
We examined the role of intracellular adhesion molecule 1 (ICAM-1 or CD54) in development pulmonary edema rabbits after artery occlusion and reperfusion using a monoclonal antibody (MAb) RR1/1 directed against ICAM-1, ligand for CD18 leukocyte glycoprotein complex. A vascular clamp was placed around left 24 h then released to allow 2 h. Lungs subjected unilateral showed increased binding 125I-labeled immunocytochemical evidence ICAM-1 expression endothelial cells compared with contralateral...
We studied the effects of pretreatment rabbits with a monoclonal antibody (MoAb) IB4 directed against an epitope on common beta-chain leukocyte adhesion glycoprotein CD18 development pulmonary edema following artery occlusion and reperfusion. A balloon catheter occluded right in for 24 h, was then deflated to allow reperfusion 2 h. The lungs were removed, attached weighing balance, perfused Ringer-albumin solution (0.5 g/100 ml). mg/kg) infused 45 min before start In another experiment, we...
Endothelins are endothelial cell-derived peptides with potent vasoconstrictor properties. We investigated the actions of porcine/human endothelin-1 (ET-1) on microvasculature guinea pig lung perfused at constant flow Ringers-albumin. measured perfusion pressure, distribution pulmonary vascular resistance (using double occlusion method), weight change, and capillary filtration coefficient. At concentrations greater than or equal to 10(-10) M, ET-1 produced dose-dependent increases in mean...
Objectives: To determine systemic hypothermia's effect on circulating immune cells and their corresponding chemokines after hypoxic ischemic encephalopathy in neonates. Design: In our randomized, controlled, multicenter trial of hypothermia neonatal encephalopathy, we measured total leukocyte subset serum chemokine levels over time both normothermia groups, as primary outcomes for safety. Setting: Neonatal ICUs participating a Neurological Disorders Stroke sponsored clinical therapeutic...
Introduction. Previous trials of surfactant therapy in premature infants have demonstrated a survival advantage associated with prophylactic as an immediate bolus, compared the rescue treatment established respiratory distress syndrome. The optimal strategy for therapy, however, remains controversial. When administered endotracheal bolus immediately after delivery, mixes absorbing fetal lung fluid and may reach alveoli before onset injury. This approach, causes brief delay initiation...
<b>Background</b> Extrauterine growth restriction (EUGR) is inversely related to neurodevelopmental outcome. We analyzed outcomes and enteral nutrition practices among preterm infants at New York State (NYS) regional perinatal centers (RPCs) identify associated with risk of EUGR. <b>Methods</b> Surviving < 31 weeks' gestation admitted a NYS RPC during 2010 were identified data collected on their from statewide database. Neonatologists RPCs surveyed center-specific nutritional practices....
Background. We previously demonstrated improved survival and early outcomes in a pilot trial of 2 doses intravenous dexamethasone for infants with surfactant-treated respiratory distress syndrome.1 A multicenter, randomized, double-blind was undertaken to confirm these results. Methods. Infants &lt;30 weeks' gestation were eligible if they had syndrome, required mechanical ventilation at 12 18 hours age, received least 1 dose exogenous surfactant. excluded sepsis or pneumonia suspected...
We examined the basis of reperfusion-induced pulmonary edema produced by artery occlusion and subsequent reperfusion. After a 24-h period rabbit followed 2-h reperfusion, lungs were removed from animal perfused with 0.5 g% Ringer's-albumin solution. An increase in lung weight was observed within 60 min compared control (i.e., subjected to arterial but not reperfusion) (p < 0.05). Shorter periods (6 or 12 h) did result edema, which suggests that ischemia required for edema. The extravascular...
We studied the changes in pulmonary hemodynamics and lung wet weight induced with opsonized zymosan (OZ) isolated guinea pig lungs perfused Ringer-albumin solution containing neutrophils (PMNs). Addition of OZ to PMN-perfused caused vasoconstriction gain; neither nor PMNs added individually perfusate altered vasomotor tone or weight. The steady gain by 1,588 +/- 464 mg over 45-minute study period was associated capillary hypertension an increase filtration coefficient, indicative increased...
We examined the direct effects of thrombin on pulmonary vasomotor tone in isolated guinea pig lungs perfused with Ringer albumin (0.5% g/100 ml). The injection alpha-thrombin (the native enzyme) resulted rapid dose-dependent increases arterial pressure (Ppa) and capillary (Ppc), which were associated an increase lung effluent thromboxane B2 concentration. Ppa Ppc responses decreased time but then increased again within 40 min after injection. primarily result postcapillary vasoconstriction....
Cytokines may function as mediators of reperfusion tissue injury in lungs. Because the lung contains resident macrophages that can serve potential sources cytokines, we examined possibility pulmonary artery occlusion by is a factor mediating release cytokines. After left ischemia induced 24-h period occlusion, observed transient increase TNF-α concentration effluent rabbits during reperfusion. The peak levels ranged from 55 to 335 pg/ml, and mean time was at 45 60 min after initiation...
We examined whether the generation of tumor necrosis factor (TNF-alpha) after lipopolysaccharide (LPS) challenge contributes to increases in lung vascular permeability and water content. Guinea pig lungs perfused at constant flow with Ringer-albumin solution (0.5 g/100 ml) were challenged for 120 min LPS (Escherichia coli; final concentration 33 ng/ml; n = 5). Lung effluent samples assayed TNF-alpha activity using modified L-929 fibroblast cytolytic assay. concentrations increased a...