A5000821609- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Urinary Tract Infections Management
- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- COVID-19 and healthcare impacts
- Child and Adolescent Health
- COVID-19 Clinical Research Studies
- Healthcare Policy and Management
- Hormonal Regulation and Hypertension
- Renal Diseases and Glomerulopathies
- COVID-19 Impact on Reproduction
- Gastroesophageal reflux and treatments
- Asthma and respiratory diseases
- Vitamin K Research Studies
- Ion Transport and Channel Regulation
- Adolescent and Pediatric Healthcare
- Sexual function and dysfunction studies
- Urticaria and Related Conditions
- Prenatal Substance Exposure Effects
- Complement system in diseases
- Alcohol Consumption and Health Effects
- Respiratory viral infections research
- Congenital Heart Disease Studies
- Gastrointestinal motility and disorders
Antwerp University Hospital
2005-2024
VIB-UGent Center for Inflammation Research
2024
University of Antwerp
2008-2023
Ziekenhuisnetwerk Antwerpen Stuivenberg
2021-2023
Gazi University
2022
Queen Fabiola Children's University Hospital
2013
Biomedical Informatics Research Center Antwerp
2007
Emma Kinderziekenhuis
2005-2006
Stay-at-home orders, physical distancing, face masks and other non-pharmaceutical interventions (NPIs) do not only impact COVID-19, but also the dynamics of various infectious diseases. Bronchiolitis is a clinically diagnosed viral infection lower respiratory tract, causes yearly seasonal wave admissions in paediatric wards worldwide. We counted 92,5% less bronchiolitis hospitalisations Antwerp before expected end peak this year (of which 1 RSV positive), as compared to last 3 years....
Objective Functional urinary incontinence causes considerable morbidity in 8.4% of school-age children, mainly girls. To compare oxybutynin, placebo, and bladder training overactive (OAB), cognitive treatment pelvic floor dysfunctional voiding (DV), a multi-center controlled trial was designed, the European Bladder Dysfunction Study. Methods Seventy girls 27 boys with clinically diagnosed OAB urge were randomly allocated to or (branch I), 89 16 DV either II). All children received...
No AccessJournal of UrologyPediatric Urology1 Oct 2008The Relevance Urodynamic Studies for Urge Syndrome and Dysfunctional Voiding: A Multicenter Controlled Trial in Childrenis accompanied byEvaluating Children With Nonneurogenic Voiding Disorders—Can We Do Better?Sonic Hedgehog Mediator Gli2 Regulates Bladder Mesenchymal Patterning An Bael, Hildegard Lax, Tom P.V.M. de Jong, Piet Hoebeke, Rien J.M. Nijman, Rune Sixt, John Verhulst, Herbert Hirche, Jan D. van Gool, European Dysfunction Study...
Authors from Belgium, the Netherlands and Germany tried to clarify relationship between disordered defecation non‐neuropathic bladder‐sphincter dysfunction; they found few arguments for a casual these conditions. OBJECTIVE To dysfunction (NNBSD) by comparing prevalence of symptoms in children with NNBSD before after treatment urinary incontinence (UI), assessing effect such on cure rate UI. PATIENTS AND METHODS In European Bladder Dysfunction Study, prospective multicentre study plans NNBSD,...
No AccessJournal of UrologyPediatric urology1 Mar 2008Improving the Cure Rate Alarm Treatment for Monosymptomatic Nocturnal Enuresis by Increasing Bladder Capacity—A Randomized Controlled Trial in Childrenis accompanied byThe Dilemmas Refractory Koen J. Van Hoeck, An Bael, Hildegard Lax, Herbert Hirche, Kim Bernaerts, Veronique Vandermaelen, and Jan D. van Gool HoeckKoen Hoeck Department Pediatrics, University Hospital Antwerp, Belgium , BaelAn Bael LaxHildegard Lax Institute Medical...
We assessed prospectively the efficacy of holding exercises and/or antimuscarinics (oxybutynin chloride and placebo) for increasing maximum voided volume in prepubertal children with monosymptomatic nocturnal enuresis.We randomly allocated 149 to 5 groups, namely placebo (group A), oxybutynin B), alone C), D) alarm treatment (controls, group E). Maximum was greatest from a 48-hour bladder diary, exercise produced postponement voiding after fluid load, once daily 4 days. Study medication,...
OBJECTIVE To determine the congruence between self‐reported and objective data on incontinence, voided volume (VV) voiding frequency (VF), in a prospective study of treatment functional urinary incontinence (UI) due to urge syndrome or dysfunctional children. PATIENTS AND METHODS In all, 202 children, enrolled European Bladder Dysfunction Study (EBDS), provided UI, VV VF, before after treatment, with validated questionnaires 72‐h diaries. Objective were obtained uroflowmetry 12‐h pad test,...
OBJECTIVE. The purpose of this work was to analyze prospectively the prevalence behavioral disorders in children with urinary incontinence because nonneuropathic bladder-sphincter dysfunction before and after treatment for incontinence. METHODS. A total 202 were enrolled European Bladder Dysfunction Study, branches urge syndrome (branch 1) dysfunctional voiding 2); 188 filled out Achenbach's Child Behavior Checklist 111 treatment. scales behavior problems used along subscales externalizing...
Abstract This study assessed HRQoL and emotional behavioral difficulties (EBD) associated variables in children with first onset SSNS. While relapsing steroid-sensitive nephrotic syndrome (SSNS) is lower health-related quality of life (HRQoL), little known about onset. Four weeks after onset, (2–16 years) and/or their parents who participated a randomized placebo-controlled trial, completed the Pediatric Quality Life Inventory 4.0 (PedsQL) Strengths Difficulties Questionnaire (SDQ) to...
In the setting of European Bladder Dysfunction Study, a multicenter, randomized, controlled trial treatment options for functional incontinence in children, we assessed concordance between reported and reviewed urodynamic scores.A total 97 children with clinically diagnosed urge syndrome 105 dysfunctional voiding enrolled Study underwent full studies before immediately after urinary incontinence. Photocopies 72% original recordings were available blinded review.The detrusor overactivity...
Binge drinking among adolescents is common in Belgium, posing a risk of serious health consequences. Until today, only estimations the prevalence acute alcohol intoxication (AAI) have been made. Research into potential factors has not yet conducted Belgium. Therefore, this study aims to gain more insight prevalence, medical characteristics and AAI adolescents. A retrospective multicentre chart was performed on aged 10–17 years with Antwerp, Belgium (2015–2021). Patient’s demographics,...
Linear correlations for cystometric/cystographic bladder capacity with age universally serve as clinical yardsticks in pediatric urology and nephrology. However, these do not account growth or the range values, relation of is nonlinear. Also, vesicoureteral reflux might influence size capacity, since small large capacities have been reported conjunction reflux. We decided to use data sets International Reflux Study Children construct full reference ranges age, comparison existing normal...
Expert consensus papers recommend differentiating enuresis using questionnaires and voiding diaries into non- (NMNE) monosymptomatic (MNE) is crucial at intake to decide the most appropriate workout treatment. This national, Belgian, prospective study investigates correlation, consistency, added value of two methods, new against old International Children’s Continence Society (ICCS) definitions, documents prevalence subtypes in our population. Ninety treatment-naïve enuretic children were...
A 4-year-old girl with diarrhea-associated hemolytic uremic syndrome (D+HUS) was transferred to the PICU of our center due deteriorating renal function and neurological involvement. On admission, a comatous child seen hypoventilation she placed on mechanical ventilation. Hemodialysis commenced but plasma exchange discontinued repeated hypersensitivity reactions. trial eculizumab given in light worsening her neurologic condition development pyramidal deepening coma. Hematological improvement...
Asthma is the most prevalent chronic respiratory condition in children. An asthma exacerbation (AE) a frequent reason for emergency department (ED) visits. important step management of moderate to severe AE administration systemic corticosteroids (SCS) within 1 h after ED presentation. This study aimed determine timing SCS and correlate this with length stay oxygen therapy duration explore factors predicting timely administration. used retrospective multicenter observational design based on...
Steroid-sensitive nephrotic syndrome (SSNS) is associated with a relapsing-remitting course that can be stressful for parents. As little known of parental distress at the first onset SSNS, this study aims to describe and everyday problems in mothers fathers child newly diagnosed SSNS participating randomized controlled trial levamisole added corticosteroids.To assess distress, Distress Thermometer Parents (DT-P) was used, which includes questions on (thermometer score 0-10, ≥ 4 "clinical...
In order to achieve urinary and faecal continence an efficient control on both systems is necessary, which means equilibrium between the two important phases of each system: storage emptying. This implicates not only pelvic floor muscles (contraction relaxation) but also a correct interpretation sensorial information during functional alternative leading social acceptable responses by “automatic” voluntary procedures. Those automatic are part learning process.
Abstract Deletions of the NaPi2a gene and mutations in SLC34A should be considered patients with atypical presentation, without phosphaturia, mild hypo to normal phosphatemia, nephrocalcinosis.