A5009967658- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Dialysis and Renal Disease Management
- Pediatric Urology and Nephrology Studies
- Electrolyte and hormonal disorders
- Urinary Tract Infections Management
- Renal Transplantation Outcomes and Treatments
- Urological Disorders and Treatments
- Adolescent and Pediatric Healthcare
- Pharmaceutical studies and practices
- Organ Donation and Transplantation
- Renal Diseases and Glomerulopathies
- Renal function and acid-base balance
- Childhood Cancer Survivors' Quality of Life
- Blood Pressure and Hypertension Studies
- Organ Transplantation Techniques and Outcomes
- Pregnancy and Medication Impact
- Pharmacological Effects and Toxicity Studies
- Liver Disease and Transplantation
- Complement system in diseases
- Renal and related cancers
- Vascular anomalies and interventions
- Ion Transport and Channel Regulation
- Kidney Stones and Urolithiasis Treatments
- Biomedical Research and Pathophysiology
Ghent University Hospital
2016-2025
Ghent University
2004-2024
ERKNet
2024
Universitair Ziekenhuis Brussel
2010-2023
University Hospital Heidelberg
2023
ERN GUARD-Heart
2023
Heidelberg University
2023
Pediatric Nephrology of Alabama
2018
Pediatrics and Genetics
2018
AZ Sint-Lucas
2016
Autosomal-dominant tubulo-interstitial kidney disease (ADTKD) encompasses a group of disorders characterized by renal tubular and interstitial abnormalities, leading to slow progressive loss function requiring dialysis transplantation. Mutations in UMOD, MUC1, REN are responsible for many, but not all, cases ADTKD. We report on two families with ADTKD congenital anemia accompanied either intrauterine growth retardation or neutropenia. Ultrasound biopsy revealed small dysplastic kidneys cysts...
Objective To ascertain the aetiology and epidemiology of non‐neurogenic bladder sphincter dysfunction (NNBSD) by assessing results prospective video‐urodynamic studies (VUD) in 1000 children. Patients methods During a 4‐year study period (January 1995 to December 1998) children prospectively underwent VUD further define their NNBSD. After noninvasive screening assessment consisting history, voiding diary, clinical examination, urine analysis, ultrasonography uroflowmetry, those who would...
To determine sleep fragmentation in children with nocturnal enuresis (NE).Paediatricians assessed NE parameters referred to an clinic. Control subjects, matched by age and gender without incontinence or (un)treated NE, were recruited from the paediatric clinic regardless of their problem. Sleep was investigated one overnight video-polysomnography both groups.The study group comprised 67 proven (50 boys 17 girls between six 16 years: 11.1 ± 2.8 SD). They control subjects (47 20 aged 11.0 2.9...
Levamisole has been considered the least toxic and expensive steroid-sparing drug for preventing relapses of steroid-sensitive idiopathic nephrotic syndrome (SSINS). However, evidence this is limited as previous randomized clinical trials were found to have methodological limitations. Therefore, we conducted an international multicenter, placebo-controlled, double-blind, trial reassess its usefulness in prevention children with SSINS. The efficacy safety one year levamisole treatment SSINS...
To assess health-related quality of life (HRQoL) across three renal replacement therapy modalities (preemptive transplant, non-preemptive and dialysis) in comparison with the healthy norm other chronic health conditions, to explore related patient factors. All prevalent end-stage disease (ESRD) patients aged 8–18 years who spent at least 6 months on their current treatment modality Netherlands, Belgium, part Germany were approached complete Pediatric Quality Life Inventory 4.0 (PedsQL™)...
Neuromodulation has been used to treat voiding dysfunction in adults. Due its invasiveness it rarely children until now with the availability of transcutaneous neurostimulation. We evaluated clinical effects neuromodulation on detrusor overactivity urge syndrome.Between May 1, 1998 and February 28, 1999, 15 girls (mean age 10.2 years) 26 boys 10.7 proved hyperactivity videourodynamic study underwent neuromodulation. All had given anticholinergic therapy previously. Neurostimulation only was...
To analyse experience in treating young children (4-5 years old) with urodynamically confirmed voiding dysfunction, using a noninvasive training programme.Between January 1996 and October 1997, 20 (all < 5 old, mean age 4.45 years, 18 girls two boys, ages 4.44 4.5 respectively) dysfunction were treated. Three showed filling phase alone (bladder instability), six emptying (dysfunctional voiding) 11 both dysfunction. Sixteen had incontinence problems (three diurnal, nocturnal diurnal...
The relation between sleep and nocturnal enuresis has been an area of discussion for many years. Children with are generally believed to have that is too deep decreased arousability. We investigated characteristics in children refractory enuresis.Nine girls 20 boys 5 19 years old (mean +/- SD age 12.1 2.7) diagnosed desmopressin dependent (14) and/or resistant (15) polyuria underwent a standardized investigation protocol, including 1 night polysomnography. Two groups 4 2 9 old, 16 7 10 were...
Desmopressin is a standard treatment for monosymptomatic nocturnal enuresis. Different formulations are promoted as bioequivalent, although these claims not supported by comparative pharmacodynamic data in children. Food interaction known to influence the bioavailability of desmopressin. We compared pharmacodynamics 2 most frequently used desmopressin formulations, tablet and lyophilizate, with standardized meal, allowing extrapolation clinical reality, where interval between evening meal...
The COVID-19 pandemic and associated quarantine measures highly impacted parental psychological well-being. Parents of children with chronic diseases might be specifically vulnerable as they already face multiple challenges to provide adequate care for their child. research questions the current study were twofold: (a) examine whether parents a disease experienced more anxiety depression compared healthy (b) series risk factors worsened well-being (i.e., depression, anxiety, sleep problems),...
Imbalanced colonic microbial metabolism plays a pivotal role in generating protein-bound uraemic toxins (PBUTs), which accumulate with deteriorating kidney function and contribute to the burden of children chronic disease (CKD). Dietary choices impact gut microbiome metabolism. The aim this study was investigate relation between dietary fibre gut-derived PBUTs paediatric CKD. Sixty-one (44 male) CKD (9 ± 5 years) were prospectively followed for two years. intake evaluated by either 24-h...
Monosymptomatic nocturnal enuresis is frequently associated with polyuria and low urinary osmolality during the night. Initial studies found decreased vasopressin levels overnight. Together documented desmopressin response, this was suggestive of a primary role for in pathogenesis absence bladder dysfunction. Recent no longer confirm vasopressin. Other pathogenetic factors such as disordered renal sodium handling, hypercalciuria, increased prostaglandins and/or osmotic excretion might have...
Our primary purpose was to determine the normal range and variability of blood volume (BV) in healthy children, order provide reference values during childhood adolescence. secondary aim correlate these vascular volumes body size parameters pubertal stages, best normalisation parameter.Plasma (PV) red cell (RCV) were measured F-cell ratio calculated 77 children with idiopathic nephrotic syndrome drug-free remission (mean age, 9.8 +/- 4.6 y). BV as sum PV RCV. Due dependence on sex, all data...
With the availability of once daily oral antimuscarinic agent solifenacin (5 mg), we started to use it for therapy resistant overactive bladder. We evaluate side effects and efficacy.We reviewed charts children treated with succinate between August 2005 2008 OAB. Incontinence was compared at study entry end.During period 84 boys 54 girls a mean age 9 years 2 months received solifenacin. Mean followup 22.59 months. While on solifenacin, were observed in 138 patients (6.5%). Efficacy...
IntroductionGrowth failure is considered the most important clinical outcome parameter in childhood chronic kidney disease (CKD). Central pathophysiology of growth presence a pro-inflammatory state, presumed partly driven by accumulation uremic toxins. In this study, we assessed association between toxin concentrations and height velocity longitudinal multicentric prospective pediatric CKD cohort (pre-)school aged children during pubertal stages.MethodsIn prospective, observational selection...