A5032341136- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Renal and Vascular Pathologies
- Neurological Complications and Syndromes
- Pregnancy and Medication Impact
- Dialysis and Renal Disease Management
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Reproductive Health and Technologies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- German Literature and Culture Studies
- Blood donation and transfusion practices
- Cytomegalovirus and herpesvirus research
- HIV/AIDS drug development and treatment
- Renal and related cancers
- Complement system in diseases
- Service-Oriented Architecture and Web Services
- Gout, Hyperuricemia, Uric Acid
- Biomedical Research and Pathophysiology
- Birth, Development, and Health
- Eosinophilic Disorders and Syndromes
- Hepatitis C virus research
- HIV/AIDS Research and Interventions
University of Minnesota
2006-2025
University of Minnesota System
2025
NHS Blood and Transplant
2025
University of Minnesota Medical Center
2023
Twin Cities Orthopedics
2023
Hypertension Institute
2023
Metabolism and Renal Physiology
2014
Autosomal-dominant tubulo-interstitial kidney disease (ADTKD) encompasses a group of disorders characterized by renal tubular and interstitial abnormalities, leading to slow progressive loss function requiring dialysis transplantation. Mutations in UMOD, MUC1, REN are responsible for many, but not all, cases ADTKD. We report on two families with ADTKD congenital anemia accompanied either intrauterine growth retardation or neutropenia. Ultrasound biopsy revealed small dysplastic kidneys cysts...
Previous studies reported the risk of ESRD after kidney donation, but not renal outcomes that precede ESRD. Here, we estimated proteinuria, reduced GFR, and in 3956 white donors, assessed contribution postdonation hypertension diabetes to these outcomes, developed a calculator. After mean±SD follow-up 16.6±11.9 years, 215 (6.1%) donors proteinuria. Men had higher proteinuria (hazard ratio [HR], 1.56; 95% confidence interval [95% CI], 1.18 2.05; P <0.001) as did those with body mass index...
Background The upper age limit to receive a kidney transplant has progressively risen, but the outcomes of elderly (ages ≥65 years) recipients remain understudied. We therefore evaluated mortality, graft failure, and predictors these in this population. Methods Three cohorts transplanted between 1963 2012 <50 years [n=2900], 50–64 [n=1218], [n=364] at transplantation) were compared for allograft patient outcomes. similar after 2000 (n=1410) studied separately address era effect. Results...
Summary Background and objectives Rapid discontinuation of prednisone after kidney transplantation potentially allows for minimization steroid-related side effects. Although intermediate-term data with rapid have been promising, concern still exists regarding long-term outcomes. The 10-year experience is reported herein. Design, setting, participants, & measurements Between October 1, 1999 December 31, 2010, 1241 adult primary transplants (791 living donor 450 deceased donor) were...
Objectives To evaluate quality of life (QOL) in kidney transplant recipients aged 65 and older, identify predictors impaired physical mental QOL cross‐sectionally compare over time with that younger general population controls. Design Comparison serial Medical Outcomes Study 36‐item Short‐Form Survey ( SF ‐36) scores older those than controls from the National Health Measurement NHMS ). Setting University Minnesota. Participants Individuals (n = 150) 1,544) who received a primary between...
Renal insufficiency is common after non-renal organ transplants. The predictors of long-term renal outcomes are not well established. A total 219 lung and heart-lung transplant recipients surviving more than 6 months transplantation were studied to determine time doubling serum creatinine end-stage kidney disease (ESKD) with death as a competing risk. Median follow-up was 79 (range 9-222 months). Baseline estimated glomerular filtration rate (GFR) 96.3+/-34.5 mL/min/1.73 m2. One hundred...
Recurrent glomerulonephritis (GN) remains an important cause of kidney allograft loss and whether rapid discontinuation steroids (RDS) is associated with a higher risk recurrence not known.We studied rate, graft patient survival in four groups recipients: 216 recipients GN transplanted under RDS (group 1), 978 concurrent non-GN 2), 260 historic comparator group for between 1994 1999 steroid maintenance 3), 950 who were also maintained on 4). Regression analysis adjusting donor recipient...
In Brief Background Short- and intermediate-term results have been reported after rapid discontinuation of prednisone (RDP) in kidney transplant recipients. Yet there has residual concern about late graft failure the absence maintenance prednisone. Methods From October 1, 1999, through June 2015, we performed a total 1553 adult first second transplants—1021 with living donor, 532 deceased donor—under our RDP protocol. We analyzed 15-year actuarial overall patient survival (PS), (GS),...
Introduction: When GFR is measured (mGFR) using iohexol plasma clearance, results are reported both as a “non-indexed” (mL/min) and “body-surface area (BSA) indexed” to 1.73 m 2 . these two values differ, there no consensus which preferable use determine suitability for living kidney donation (LKD). We sought compare the difference between non-indexed BSA indexed mGFR in LKDs association with postdonation estimated (eGFR). Methods: Between 1/1/2007-1/1/2023, 627 adult at University of...
Abstract Low birthweight is linked to hypertension, chronic kidney disease and even end‐stage renal disease. We hypothesized that living donors born with lower may be at increased risk of albuminuria, or reduced GFR beyond what typical following uninephrectomy. Two hundred fifty‐seven who donated the University Minnesota between 1967 2005 underwent iohexol urinary albumin excretion measurements. Predictors <60 mL/min/1.73 m 2 , hypertension were examined using logistic regression. include...
Background Uric acid has been linked to the progression of native kidney disease. Studies evaluating its contribution allograft function in transplant recipients, among whom hyperuricemia is common, have yielded mixed results. Methods We evaluated association between baseline uric and primary composite outcome doubling interstitium or ESRD from interstitial fibrosis tubular atrophy (IF/TA) Angiotensin II Blockade for Chronic Allograft Nephropathy (ABCAN) Trial participants. Subjects...
<b><i>Background:</i></b> The glomerular filtration rate (GFR) estimating equation incorporating both cystatin C and creatinine perform better than those using or alone in patients with reduced GFR. Whether this performs well kidney transplant recipients cross-sectionally, more importantly, over time has not been addressed. <b><i>Methods:</i></b> We analyzed four GFR equations participants of the Angiotensin II Blockade for Chronic Allograft...
Abstract Living kidney donation from donors <18 yr of age is uncommon. The majority donations adolescents took place several decades ago providing a unique opportunity to study true long‐term consequences donation. We compared survival, renal outcomes, and rates hypertension diabetes among 42 adolescent matched older controls. Adolescent were with 18–30 on the following: gender, relation recipient, BMI at donation, e GFR year After mean follow‐up 31.8 ± 8.0 yr, 94.9% alive vs. 93.8% There...
Using the Scientific Registry of Transplant Recipients, we examined association between donor-recipient biologic relationship and long-term recipient allograft survival among glomerulonephritis (GN) patients. Four GN types were studied: membranous nephropathy, IgA, lupus-associated nephritis, focal segmental glomerulosclerosis (FSGS). We identified all adult primary living-donor recipients 2000 2018 (n = 19,668): related 10,437); unrelated 9,231). Kaplan-Meier curves generated for recipient,...
Abstract Background The HIV Organ Policy Equity (HOPE) act afforded transplantation of organs from donors who have HIV. Herein we compared the long‐term outcomes recipients with by donor testing status. Methods Using Scientific Registry Transplant Recipients, identified all primary adult kidney transplant were HIV‐positive between 1/1/16‐12/31/21. Recipients grouped into three cohorts according to status based on antibody (Ab) and nucleic acid (NAT): Donor Ab−/NAT− (n = 810), Ab+ /NAT− 98),...
An understanding of long-term outcomes for kidney transplant(KTx) recipients who survive with graft function beyond a specific time posttransplant is the first step in creating protocols to optimize care current and improve future recipients. We studied 831KTx recipients-580 living donor(LD); 251 deceased donor(DD)—with survival(GS) >20 years. For primary LD recipients, 25-year patient survival(PS) was 83%; 35-year, 59%. Their death-censored survival(DCGS) 89%; 72%. DD had lower PS(P<0.01),...