A5005469133- Dialysis and Renal Disease Management
- Adolescent and Pediatric Healthcare
- Childhood Cancer Survivors' Quality of Life
- Urinary Bladder and Prostate Research
- Muscle and Compartmental Disorders
- Pharmaceutical studies and practices
- Renal function and acid-base balance
- Neurological and metabolic disorders
- Ion Transport and Channel Regulation
- Central Venous Catheters and Hemodialysis
- Electrolyte and hormonal disorders
- Motivation and Self-Concept in Sports
- Acute Kidney Injury Research
- Family and Disability Support Research
- Blood Pressure and Hypertension Studies
- Child Nutrition and Feeding Issues
- Restless Legs Syndrome Research
- Iron Metabolism and Disorders
- Erythropoietin and Anemia Treatment
- Clinical Nutrition and Gastroenterology
- Organ Donation and Transplantation
- Potassium and Related Disorders
- Birth, Development, and Health
- Asthma and respiratory diseases
- Diet and metabolism studies
Ghent University Hospital
2015-2025
Great North Children's Hospital
2024
Ghent University
2016-2024
ERKNet
2024
ERN GUARD-Heart
2024
Universitair Ziekenhuis Brussel
2023
Hospital for Sick Children
2021
KU Leuven
2019
Janssen (Belgium)
1983
Imbalanced colonic microbial metabolism plays a pivotal role in generating protein-bound uraemic toxins (PBUTs), which accumulate with deteriorating kidney function and contribute to the burden of children chronic disease (CKD). Dietary choices impact gut microbiome metabolism. The aim this study was investigate relation between dietary fibre gut-derived PBUTs paediatric CKD. Sixty-one (44 male) CKD (9 ± 5 years) were prospectively followed for two years. intake evaluated by either 24-h...
IntroductionGrowth failure is considered the most important clinical outcome parameter in childhood chronic kidney disease (CKD). Central pathophysiology of growth presence a pro-inflammatory state, presumed partly driven by accumulation uremic toxins. In this study, we assessed association between toxin concentrations and height velocity longitudinal multicentric prospective pediatric CKD cohort (pre-)school aged children during pubertal stages.MethodsIn prospective, observational selection...
Abstract Children with chronic kidney disease (CKD) are at risk for vitamin deficiency or excess. Vitamin status can be affected by diet, supplements, function, medications, and dialysis. Little is known about requirements in CKD, leading to practice variation. The Pediatric Renal Nutrition Taskforce (PRNT), an international team of pediatric dietitians nephrologists, was established develop evidence-based clinical points (CPPs) address challenges serve as a resource nutritional care....
ABSTRACT Introduction Hyperphosphataemia is a common complication of paediatric chronic kidney disease (CKD), despite the use phosphate binders and numerous strategies employed to reduce dietary (P) intake. This article describes development two self‐administered semi‐structured Phosphate Understanding Knowledge Assessment (PUKA) questionnaires. The purpose these assess challenges with adherence measure declarative nutrition procedural knowledge in children young people (CYP) CKD their...
Protein-bound uremic toxins (PBUTs) play a role in the multisystem disease that children on hemodialysis (HD) are facing, but little is known about their levels and protein binding (%PB). In this study, we evaluated %PB of six PBUTs cross-sectionally large pediatric HD cohort (n = 170) by comparing these with healthy non-dialysis chronic kidney (CKD) stage 4–5 24) children. parallel β2-microglobulin (β2M) uric acid (UA) were evaluated. We then explored impact age residual function toxin...
Haemodiafiltration (HDF) is accepted to effectively lower plasma levels of middle molecules in the long term, while data are conflicting with respect additive effect convection on lowering protein-bound uraemic toxins (PBUTs). Here we compared pre-dialysis β2-microglobulin (β2M) and PBUT percentage protein binding (%PB) children post-dilution HDF versus conventional high- (hf) or low-flux (lf) haemodialysis (HD) over 12 months treatment.In a prospective multicentre, non-randomized...
Chronic kidney disease (CKD) in childhood is poorly explained by routine markers (e.g. urea and creatinine) better depicted adults other uraemic toxins. This study describes concentrations of representative toxins non-dialysis CKD versus healthy children.In 50 children 57 with Stages 1-5 [median estimated glomerular filtration rate 48 (25th-75th percentile 24-71) mL/min/1.73 m2; none on dialysis], serum small solutes [symmetric asymmetric dimethyl-arginine (SDMA ADMA, respectively)], middle...
The benefits of dietary fiber are widely accepted.Nevertheless, a substantial proportion children fail to meet the recommended intake fiber.Achieving adequate is especially challenging in with chronic kidney disease (CKD).An international team pediatric renal dietitians and nephrologists from Pediatric Renal Nutrition Taskforce (PRNT) has developed clinical practice recommendations (CPRs) for adolescents CKD.In this CPR paper, we propose definition fiber, provide advice on requirements...