A5040815433- Antibiotics Pharmacokinetics and Efficacy
- Acute Kidney Injury Research
- Pneumonia and Respiratory Infections
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Pharmaceutical studies and practices
- Sepsis Diagnosis and Treatment
- Anesthesia and Sedative Agents
- Antibiotic Use and Resistance
- Renal function and acid-base balance
- Electrolyte and hormonal disorders
- Complement system in diseases
- Antimicrobial Resistance in Staphylococcus
- Metabolism and Genetic Disorders
- Hemodynamic Monitoring and Therapy
- Analytical Methods in Pharmaceuticals
- Pharmacological Effects and Toxicity Studies
- Neonatal Health and Biochemistry
- Bacterial Identification and Susceptibility Testing
- Iron Metabolism and Disorders
- Biosimilars and Bioanalytical Methods
- Mechanical Circulatory Support Devices
- Drug-Induced Hepatotoxicity and Protection
- Health and Medical Research Impacts
- COVID-19 Impact on Reproduction
Ghent University Hospital
2016-2025
Ghent University
2018-2024
Intensive Care Society
2018-2019
Institute of Pharmacology
2019
BG Klinik Tübingen
2004
Universitätsklinikum des Saarlandes
2004
In rare instances, pediatric SARS-CoV-2 infection results in a novel immunodysregulation syndrome termed multisystem inflammatory children (MIS-C). We compared MIS-C immunopathology with severe COVID-19 adults. does not result pneumocyte damage but is associated vascular endotheliitis and gastrointestinal epithelial injury. MIS-C, the cytokine release characterized by IFNγ type I interferon. Persistence of patrolling monocytes differentiates from COVID-19, which dominated HLA-DRlo classical...
There is little data available to guide amoxicillin-clavulanic acid dosing in critically ill children. The primary objective of this study was investigate the pharmacokinetics both compounds pediatric subpopulation. Patients admitted intensive care unit (ICU) whom intravenous indicated (25 35 mg/kg body weight every 6 h) were enrolled. Population pharmacokinetic analysis conducted, and clinical outcome documented. A total 325 151 blood samples collected from 50 patients (median age, 2.58...
Objectives: The objectives of this observational study were to investigate plasma protein binding and evaluate target attainment rates vancomycin therapy in critically ill children. Patients methods: Paediatric ICU patients, whom intravenous intermittent dosing (ID) or continuous (CD) with was indicated, included. Covariates on unbound fraction concentration tested using a linear mixed model analysis currently used pharmacokinetic/pharmacodynamic (PK/PD) targets evaluated....
OBJECTIVES: In critically ill children, severely altered pharmacokinetics may result in subtherapeutic β-lactam antibiotic concentrations when standard pediatric dosing regimens are applied. However, it remains unclear how to recognize patients most at risk for suboptimal exposure and their outcome. This study aimed to: 1) describe target attainment antibiotics 2) identify factors exposure, 3) the association between nonattainment clinical DESIGN: Post hoc analysis of “Antibiotic Dosing...
A 3-month-old boy presented with failure to thrive and a history of prenatally detected unilateral hydroureteronephrosis which was confirmed after birth. His growth developmental milestones had been normal during the first 2 months but in third month his appetite poor reduced intake no vomiting. At presentation, temperature normal, there mild dehydration weight loss (his decreased by 270 g past month). Haemoglobin 11.9 g/dL, total white cell count 20.2 × 109/L (7–15) [neutrophils 30% (39–75)...
Fluoroquinolones (FQ) are increasingly prescribed for children, despite being labeled only a limited number of pediatric indications. In this multicenter retrospective drug utilization study, we analyzed indications systemic FQ prescriptions in hospitalized children and the appropriateness dose.
Background: Information on the epidemiology of Acute Kidney Injury (AKI) in children is scarce. We performed a single center retrospective cohort study to analyze incidence AKI, male/female ratio, underlying etiology, and age at presentation. also aimed assess outcome measured by mortality, duration PICU stay, development Chronic Disease (CKD).Methods: Records were searched for presenting with or developing AKI between 1st January 2008 2015. was classified according pediatric Rifle criteria...
Data published on the oral clavulanic acid pharmacokinetics in pediatric population is lacking. This research aimed to describe disposition following and intravenous administration provide insights into exposure based threshold concentrations for (pre-)term neonates infants. pooled pharmacokinetic study combined four datasets analysis NONMEM v7.4.3. Clavulanic was simulated using percentage of time above (%fT > C
Diarrhea-associated hemolytic uremic syndrome (HUS) is usually associated with shigatoxin-producing Escherichia coli or shigella infections. We report 2 cases of HUS, respectively, caused by salmonella and Campylobacter jejuni None these bacteria produce shigatoxins, the underlying mechanism HUS development remains unknown. In streptococcus pneumoniae-associated bacterial neuraminidase cleaves neuraminic acid causes exposure Thomsen-Friedenreich cryptantigen on cell surface of, for example,...
A 4-year-old girl with diarrhea-associated hemolytic uremic syndrome (D+HUS) was transferred to the PICU of our center due deteriorating renal function and neurological involvement. On admission, a comatous child seen hypoventilation she placed on mechanical ventilation. Hemodialysis commenced but plasma exchange discontinued repeated hypersensitivity reactions. trial eculizumab given in light worsening her neurologic condition development pyramidal deepening coma. Hematological improvement...
Background Amoxicillin/clavulanate is commonly used to treat community-acquired infections on the pediatric intensive care unit. Few data are available guide dosing in this vulnerable population. Methods This prospective pharmacokinetic study enrolled patients admitted unit whom intravenous amoxicillin-clavulanate was indicated (25–35 mg/kg q6h). Serial blood samples were obtained following first and steady-state doses amoxicillin/clavulanate concentrations measured by a validated...