A5024580157- Acute Kidney Injury Research
- Sepsis Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Renal function and acid-base balance
- Cardiac Arrest and Resuscitation
- Potassium and Related Disorders
- Hemodynamic Monitoring and Therapy
- Electrolyte and hormonal disorders
- Ureteral procedures and complications
- Metabolism and Genetic Disorders
- Renal and Vascular Pathologies
- Cardiac, Anesthesia and Surgical Outcomes
- Muscle and Compartmental Disorders
- Biomedical Research and Pathophysiology
- Renal Diseases and Glomerulopathies
- Organ Donation and Transplantation
- Neonatal Respiratory Health Research
- Pediatric Urology and Nephrology Studies
- Lymphatic System and Diseases
- Diet and metabolism studies
- Biomedical and Chemical Research
- Childhood Cancer Survivors' Quality of Life
- Poisoning and overdose treatments
Ghent University Hospital
2014-2024
Ghent University
2019-2022
East Kent Hospitals University NHS Foundation Trust
2012
Hôpital Necker-Enfants Malades
2010
Université Paris Cité
2010
Assistance Publique – Hôpitaux de Paris
2010
Abstract Introduction The pathophysiology of acute kidney injury (AKI) in sepsis is ill defined. We investigated parameters associated with low glomerular filtration, and their predictive value to discriminate transient from intrinsic septic AKI. Methods In 107 patients, AKI was defined by the Risk, Injury, Failure, Loss Kidney Function, End-stage renal disease (RIFLE) urinary output or serum creatinine criterion, both. Transient (TAKI) versus as RIFLE R, I, F on first day evolving no not,...
Sepsis-induced acute kidney injury (AKI) is a frequent complication of critically ill patients and leads to high mortality rates. The specificity currently available urinary biomarkers for AKI in the context sepsis questioned. This study aimed discover septic by contemporary shotgun proteomics mouse model validate these individual urine samples mice human with without AKI. At 48 h after uterine ligation inoculation Escherichia coli, aged (48 weeks) became septic. A subgroup developed AKI,...
Kidney biopsy (KB), to date the only tool for evaluation of renal fibrosis, carries specific risks, and its relevance is limited by small size parenchyma assessed. Thus, a noninvasive alternative KB required. Collagen type III amino-terminal propeptide (PIIINP) degradation product collagen III, increase which may reflect an ongoing fibrotic process.In prospective study including 199 patients with various stages chronic kidney disease (CKD), association between urinary PIIINP/creatinine ratio...
The role of neutrophil gelatinase-associated lipocalin (NGAL) as a diagnostic marker for acute kidney injury (AKI) in sepsis is still debated. We hypothesized that sepsis, the performance serum(s) and urinary(u) NGAL can be negatively impacted by severity illness inflammation, both uNGAL sNGAL levels increased regardless presence AKI.One hundred seven patients with were included. measured at admission (T0) 4 hours (T4) 24 later (T24). Transient intrinsic AKI respectively defined according to...
Abstract Most reports on AKI claim to use KDIGO guidelines but fail include the urinary output (UO) criterion in their definition of AKI. We postulated that ignoring UO alters incidence AKI, may delay diagnosis and leads underestimation association between ICU mortality. Using routinely collected data adult patients admitted an intensive care unit (ICU), we retrospectively classified according whether when they would be diagnosed with stage ≥ 2 based baseline serum creatinine (Screa) and/or...
It is unclear how modifications in the way to calculate serum creatinine (sCr) increase and cut-off value applied, influences prognostic of Acute Kidney Injury (AKI). We wanted evaluate whether these alter AKI for prediction mortality at 3 months, 1 2 years. prospectively included 195 septic patients evaluated by using three different algorithms sCr increase: either as difference between highest first 24 h after ICU admission a pre-admission historical (ΔHIS) or an estimated (ΔEST) baseline...
Purpose Septic acute kidney injury (AKI) is associated with poor outcome. This can partly be attributed to delayed diagnosis and incomplete understanding of the underlying pathophysiology. Our aim was develop an early predictive test for AKI based on analysis urinary peptide biomarkers by MALDI‐MS. Experimental design Urine samples from 95 patients sepsis were analyzed Marker search multimarker model establishment performed using profiles 17 existing or within next 5 days developing no...
Background The incidence of Acute Kidney Injury (AKI) and its human economic cost is increasing steadily. One way to reduce the burden associated with AKI prevent event altogether. An important step in prevention lies risk prediction. Due number available prediction models (RPMs) clinicians need be able rely on systematic reviews (SRs) provide an objective assessment which RPM can used a specific setting. Our aim was assess quality SRs RPMs AKI. Methods protocol for this overview registered...
Background. Fanconi syndrome (FS) is a generalized transport defect in the proximal renal tubule leading to losses of phosphate, calcium, uric acid, bicarbonates as well glucose, amino acids and other organic compounds. It caused by inherited or acquired disorders including low mass high multiple myeloma. Objectives. To report first case series patients with lymphoma FS. Design, setting, participants, measurements. Patients FS were identified nephrology department two teaching hospitals...
Background: Information on the epidemiology of Acute Kidney Injury (AKI) in children is scarce. We performed a single center retrospective cohort study to analyze incidence AKI, male/female ratio, underlying etiology, and age at presentation. also aimed assess outcome measured by mortality, duration PICU stay, development Chronic Disease (CKD).Methods: Records were searched for presenting with or developing AKI between 1st January 2008 2015. was classified according pediatric Rifle criteria...