Markus Albertsmeier
A5074202356- Sarcoma Diagnosis and Treatment
- Hernia repair and management
- Vascular Tumors and Angiosarcomas
- Pancreatic and Hepatic Oncology Research
- COVID-19 and healthcare impacts
- Cardiac tumors and thrombi
- Pelvic and Acetabular Injuries
- Cardiac, Anesthesia and Surgical Outcomes
- Surgical site infection prevention
- Gastric Cancer Management and Outcomes
- Cardiac Arrest and Resuscitation
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroblastoma Research and Treatments
- Pancreatitis Pathology and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Management of metastatic bone disease
- Esophageal and GI Pathology
- Intestinal and Peritoneal Adhesions
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Tumor Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Gastrointestinal disorders and treatments
- Trauma and Emergency Care Studies
- CAR-T cell therapy research
Ludwig-Maximilians-Universität München
2016-2025
LMU Klinikum
2012-2025
Bayer (Germany)
2025
University of Birmingham
2020-2024
München Klinik
2017-2024
National Institute for Health Research
2024
Institut de Virologie
2020-2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Background: The prognosis of patients with advanced soft tissue sarcoma (STS) remains dismal. Trofosfamide (TRO) has been proposed as a well-tolerated oral maintenance therapy. This retrospective analysis aims to determine the value this Methods: Fifty-nine STS who received TRO therapy between 2016 and 2022 were reviewed analysed regarding clinical parameters outcomes. Results: median age was 48 years; most common histological subtype synovial (n = 22, 37%), 71% 42) presented metastatic...
Abstract Background Leakage from the pancreaticojejunostomy is major cause of septic complications after partial pancreaticoduodenectomy. This study evaluated a new transpancreatic ∪-suture technique (Blumgart anastomosis, BA), which aims to avoid shear forces during knot-tying. Methods Using before–after design, BA was compared with modified Cattell–Warren anastomosis (CWA). Two patient cohorts (CWA, 90; BA, 92), were similar respect primary diagnosis, age, sex and American Society...
The CovidSurg-Cancer Consortium aimed to explore the impact of COVID-19 in surgical patients and services for solid cancers at start pandemic. CovidSurg-Gynecologic Oncology Cancer subgroup was particularly concerned about magnitude adverse outcomes caused by disrupted gynecologic cancer care during pandemic, which are currently unclear.
Surgical site infections frequently occur after open abdominal surgery. Intraoperative wound irrigation as a preventive measure is common practice worldwide, although evidence supporting this lacking.
Incisional hernia remains a frequent problem after midline laparotomy. This study compared short stitch to standard loop closure using an ultra-long-term absorbent elastic suture material.A prospective, multicentre, parallel-group, double-blind, randomized, controlled superiority trial was designed for the elective setting. Adult patients were randomly assigned by computer-generated sequence fascial (5 8 mm every 5 mm, USP 2-0, single thread HR 26 needle) or long technique (10 10 1, double...
To determine whether regional hyperthermia (RHT) in addition to chemotherapy improves local tumor control after macroscopically complete resection of abdominal or retroperitoneal high-risk sarcomas.Within the prospectively randomized EORTC 62961 phase-III trial, RHT and systemic significantly improved progression-free survival (LPFS) disease-free (DFS) patients with extremity sarcomas. That trial included R2 resections.A subgroup analysis was performed long-term determined. From 341...
Abstract Purpose The short-stitch technique for midline laparotomy closure has been shown to reduce hernia rates, but long stitches remain the standard of care and effect on short-term results is not well known. aim this study was compare two techniques, using an ultra-long-term absorbable elastic suture material. Methods Following elective laparotomy, 425 patients in 9 centres were randomised receive wound (USP 2-0 single thread, n = 215) or long-stitch 1 double loop, 210) with a...
Abstract Lymph node metastasis (LNM) occurs in less than 5% of soft tissue sarcoma (STS) patients and indicates an aggressive course disease. Suspicious lymph nodes (LN) staging imaging are a frequent topic discussion multidisciplinary tumor boards. Predictive markers needed to facilitate stratification improve treatment STS patients. In this study, 56 with radiologically suspicious subsequently histologically examined LN were reviewed. Patients benign (n = 26) metastatic 30) analyzed regard...
Abstract Background Clinical trials have shown reduced incisional hernia rates 1 year after elective median laparotomy closure using a short-stitch technique. With development continuing beyond the first postoperative year, we aimed to compare hernias 3 years midline short or long stitches in patients from ESTOIH trial. Methods The trial was prospective, multicenter, parallel-group, double-blind, randomized-controlled study of primary closure. Patients were randomized fascia short-...
Abstract Purpose The management of soft tissue sarcoma (STS) at reference centers with specialized multidisciplinary tumor boards (MTB) improves patient survival. German Cancer Society (DKG) certifies in German-speaking countries, promoting high standards care. This study investigated the variability treatment recommendations for localized STS across different tertiary centers. Methods In this cross-sectional case-based survey study, 5 anonymized cases imaging data were presented to MTBs 21...
Abstract Background Surgical site infections (SSI), mainly caused by Staphylococcus aureus, represent a significant economic burden in Europe, leading to an increase length of hospitalization, mortality and treatment costs, especially with drug-resistant strains. such as methicillin-resistant aureus. A new case-control study high-volume centers aims provide detailed data on the impact treating aureus SSIs. Methods The SALT is multinational retrospective cohort analysis focused SSIs Europe....
ABSTRACT Background Dacarbazine is currently considered the better combination partner for doxorubicin compared to ifosfamide treatment of leiomyosarcoma (LMS). Regional hyperthermia (RHT) combined with neoadjuvant chemotherapy has been shown improve survival in patients locally advanced high‐risk STS. We sought evaluate role and dacarbazine (AD) versus (AI) RHT LMS. Methods Patients high‐grade LMS, including limited metastases, eligible first‐line either AI + or AD between 2014 2022 were...
Abstract Background The current understanding of the prognostic value routine pre-treatment laboratory parameters in patients with high-risk soft tissue sarcoma (HR-STS) is limited. We sought to analyze several inflammatory biomarkers a large cohort HR-STS undergoing neoadjuvant therapy followed by curative surgical resection. Methods 123 locally advanced undifferentiated pleomorphic (UPS), liposarcoma (LPS), leiomyosarcoma (LMS), and synovial (SS) who underwent preoperative chemotherapy...
In patients with retroperitoneal sarcoma (RPS), the incidence of recurrence after surgery remains high. Novel treatment approaches are needed. This retrospective study evaluated primary, high-risk RPS who received neoadjuvant systemic therapy followed by to 1) determine frequency and potential predictors radiologic tumor responses 2) assess clinical outcomes.Clinicopathologic data were collected for eligible treated at 13 referral centers from 2008 2018. Univariable multivariable logistic...
Different suture techniques and various materials are in use to close midline incisions after primary laparotomy. The ISSAAC study aimed assess the safety efficacy of new ultra-long-term absorbable, elastic monofilament material MonoMax® for abdominal wall closure. This is a single-arm, multicentre prospective that included 150 patients undergoing elective incision. control group consists 141 from INSECT who received MonoPlus® or PDS® incidences burst abdomen wound infection until day...
Macrophages have been reported to initiate immunosuppression following trauma and hemorrhage, recent experimental studies suggest a pivotal role of T-cells in maintaining immunosuppression. The aim the present study was investigate interaction APC humans major surgery. First, from 14 surgical patients were isolated, counted characterized by their specific surface marker profile 2 24 h postoperatively. Then, these cells co-incubated with other type, which had isolated pre-operatively....
(1) Background: PRAME, NY-ESO-1, and SSX2 are cancer testis antigens (CTAs), which expressed in testicular germ cells with re-expression numerous types. Their ability to elicit humoral cellular immune responses have rendered them promising targets for immunotherapy, but they never been studied a large well-characterised cohort of soft tissue sarcomas (STS). (2) Methods: On protein level, we examined expression tumour tissues 249 high-risk STS using immunohistochemistry. We correlated levels...