A5067266397- Advanced X-ray and CT Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiation Dose and Imaging
- Cardiac Imaging and Diagnostics
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Medical Imaging Techniques and Applications
- Renal cell carcinoma treatment
- Ultrasound in Clinical Applications
- Shoulder Injury and Treatment
- Aortic aneurysm repair treatments
- Shoulder and Clavicle Injuries
- Cardiac Valve Diseases and Treatments
- Sports injuries and prevention
- Cardiovascular Disease and Adiposity
- Ultrasound and Hyperthermia Applications
- Radiomics and Machine Learning in Medical Imaging
- Aortic Disease and Treatment Approaches
- Neuroendocrine Tumor Research Advances
- Pituitary Gland Disorders and Treatments
- Cardiovascular Effects of Exercise
- Infective Endocarditis Diagnosis and Management
- Medical Imaging and Pathology Studies
- Lymphoma Diagnosis and Treatment
University Children's Hospital Tübingen
2020-2025
University of Tübingen
2020-2024
Medizinische Hochschule Hannover
2018
Max Planck Institute of Psychiatry
2016
Ludwig-Maximilians-Universität München
2016
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016
The purpose of this study was to evaluate the capabilities photon-counting (PC) CT combined with artificial intelligence-derived coronary computed tomography angiography (PC-CCTA) stenosis quantification and fractional flow reserve prediction (FFRai) for assessment artery disease (CAD) in transcatheter aortic valve replacement (TAVR) work-up.
This study investigated the efficacy of single-phase dual-energy CT (DECT) in differentiating pulmonary hamartomas from malignant lung lesions using virtual non-contrast (VNC), iodine, and fat quantification. Forty-six patients with 47 (mean age: 65.2 ± 12.1 years; hamartomas-to-malignant = 22:25; male: 67%) underwent portal venous DECT histology, PET-CT follow-up CTs as a reference. Quantitative parameters such VNC, fraction, iodine density mixed values were statistically analyzed....
Abstract Purpose The management of soft tissue sarcoma (STS) at reference centers with specialized multidisciplinary tumor boards (MTB) improves patient survival. German Cancer Society (DKG) certifies in German-speaking countries, promoting high standards care. This study investigated the variability treatment recommendations for localized STS across different tertiary centers. Methods In this cross-sectional case-based survey study, 5 anonymized cases imaging data were presented to MTBs 21...
Understanding determinants of thoracic aortic morphology is crucial for precise diagnostics and therapeutic approaches. This study aimed to automatically characterize ascending based on 3D non-contrast-enhanced magnetic resonance angiography (NC-MRA) data from the epidemiological cross-sectional German National Cohort (NAKO) investigate possible mid-ascending diameter (mid-AAoD). Deep learning (DL) segmented aorta length, volume, was extracted 25,073 NC-MRAs. Statistical analyses...
Subjective and objective image quality comparison of bone microstructure disease-related abnormalities in multiple myeloma patients using a 1st-generation dual-source photon-counting detector CT(DS-PCD-CT) 2nd-generation dual-energy (energy-integrating detector) CT (DS-EID-CT).Fifty (mean age 67.7 ± 10.9 years,16 females) were prospectively enrolled. Unenhanced whole-body CTs clinically indicated performed on DS-EID-CT DS-PCD-CT (median time difference: 12 months). was Quantumplus UHR mode...
PURPOSE Differentiation of incidental adrenal lesions remains a challenge in diagnostic imaging, especially on single-phase portal venous computed tomography (CT) the oncological setting. The aim study was to explore ability dual-energy CT (DECT)-based iodine quantification and virtual non-contrast (VNC) imaging advanced radiomic analysis DECT for differentiation adenomas from metastases. METHODS A total 46 patients with 49 underwent clinically indicated staging magnetic resonance imaging....
Purpose: To investigate technical success, technique efficacy, safety and outcome of MR-guided microwave ablation (MWA) in hepatic malignancies.Material methods: In this prospective IRB-approved study, patients scheduled for percutaneous treatment malignancies underwent MWA a closed-bore 1.5 T MR system. Technical success was assessed on post-procedural control imaging. Technique efficacy evaluated 4 weeks after the procedure multi-parametric MRI. Assessment followed Society Interventional...
Purpose: The purpose of this study was to develop and validate a deep learning-based framework for automated segmentation vessel shape analysis on non–contrast-enhanced magnetic resonance (MR) data the thoracic aorta within German National Cohort (GNC) MR study. Materials Methods: One hundred sets acquired in GNC were included (56 men, average age 53 y [22 72 y]). All participants had undergone imaging vessels. Automated performed using Convolutional Neural Network supervised setting with...
Abstract Purpose Evaluation of technique effectiveness, patient safety and ablation parameters MR-guided microwave in hepatic malignancies using an MR-conditional high-power system. Materials Methods Institutional review board approval informed consent were obtained. Patients who underwent a 1.5T wide-bore scanner perfusion-cooled system with maximum generator power 150 W included. Ablation comprising procedure durations, net duration, applicator positions zone dimensions recorded. Adverse...
Abstract Purpose This study evaluates the diagnostic performance of artificial intelligence (AI)-based coronary computed tomography angiography (CCTA) for detecting artery disease (CAD) and assessing fractional flow reserve (FFR) in asymptomatic male marathon runners. Material methods We prospectively recruited 100 runners over age 45 CAD screening. CCTA was analyzed using AI models (CorEx Spimed-AI) on a local server. The focused significant (≥ 50% diameter stenosis, CAD-RADS 3, 4, or 5)...
Combination therapy using hepatic resection (HR) and intra-operative thermal ablation is a treatment approach for patients with technically unresectable liver malignancies. The aim of this study was to investigate safety, survival local recurrence rates tumors undergoing HR separate percutaneous MR-guided thermoablation procedure as an alternative approach.Data from all primary or secondary malignancies treated at single institution between 2004 2018 combined collected retrospectively...
Purpose Evaluation of machine learning-based fully automated artery-specific coronary artery calcium (CAC) scoring software, using semi-automated software as a reference. Methods A total 505 patients underwent non-contrast-enhanced computed tomography (CSCT). Automated, quantified the Agatston score (AS), volume (VS), and mass (MS) each [right (RCA), left main (LM), circumflex (CX) anterior descending (LAD)]. Identified CAC readers who annotated data with served reference standard....
Abstract Background We evaluated a magnetic resonance (MR)-conditional high-power microwave ablation system. Methods An ex vivo 1.5-T evaluation was conducted by varying the sequence (T1-weighted volume interpolated breath-hold examination, T1w-VIBE; T1-weighted fast low-angle shot, T1w-FLASH; T2-weighted turbo spin-echo, T2w-TSE), applicator angulation to B 0 ( A -to- ), slice orientation, and encoding direction. Tip location error (TLE) artefact diameters were measured, influence of...
(1) Background: To evaluate the diagnostic performance of a simulated ultra-low-dose (ULD), high-pitch computed tomography pulmonary angiography (CTPA) protocol with low tube current (mAs) and reduced scan range for detection embolisms (PE). (2) Methods: We retrospectively included 130 consecutive patients (64 ± 16 years, 69 female) who underwent clinically indicated CTPA examination suspected acute PE on 3rd generation dual-source CT scanner (SOMATOM FORCE, Siemens Healthineers, Forchheim,...
Abstract Background Radiofrequency ablation (RFA) is a minimal-invasive, local therapy in patients with circumscribed metastatic disease. Although widely used, long time survival analysis of treated liver metastases still pending while also analysing the patients’ experience MR-based radiofrequency. Methods Monocentric, retrospective long-time overall and progression free (OS; PFS) 109 patients, MRI-guided hepatic RFA between 1997 2010, focusing on colorectal cancer (CRC). Complimentary...
The purpose of this study was to evaluate the potential dual-energy CT (DECT) with virtual unenhanced imaging (VNC) and iodine maps (IM) differentiate between intraperitoneal hematomas (IH) bowel structures (BS) compared linearly blended DECT (DE-LB) images (equivalent single-energy CT). This retrospective included 30 patients (mean age: 64.5 ± 15.1 years, 19 men) negative controls. VNC, IM, DE-LB were calculated. Imaging follow-up surgical reports used as references. Three readers assessed...
To evaluate the effect of radiation dose reduction on image quality and diagnostic confidence in contrast-enhanced whole-body computed tomography (WBCT) staging. We randomly selected March 2016 for retrospective inclusion 18 consecutive patients (14 female, 60 ± 15 years) with clinically indicated WBCT staging same 3rd generation dual-source CT. Using low-dose simulations, we created data sets 100, 80, 60, 40, 20% original dose. Each set was reconstructed using filtered back projection (FBP)...
The aim of this study was to investigate the effects dose reduction on diagnostic accuracy and image quality cervical computed tomography (CT) in patients with suspected abscess. Forty-eight (mean age 45.5 years) received a CT for Low-dose (LDCT) datasets 25%, 50%, 75% original were generated realistic simulation. data reconstructed filtered back projection (FBP) advanced modeled iterative reconstruction (ADMIRE) (strengths 3 5). A five-point Likert scale used assess subjective confidence....
Hepatic recurrence of liver malignancies is a leading problem in patients after resection with curative intention. Thermoablation promising treatment approach for hepatic resection, especially liver-limited conditions. This study aimed to investigate safety, survival, and local tumor control rates MRI-guided percutaneous thermoablation recurrent following resection.Data from primary or secondary treated between 2004 2018 prior were retrospectively analyzed. Disease-free survival overall...
ABSTRACT Background Pathologies of the thoracic aorta are associated with chronic cardiovascular disease and can be life-threatening nature. Understanding determinants aortic morphology is crucial for precise diagnostics preventive therapeutic approaches. This study aimed to automatically characterize ascending based on 3D non-contrast-enhanced magnetic resonance angiography (NE-MRA) data from large epidemiological cross-sectional German National Cohort (NAKO) investigate possible...