A5082261117- Bariatric Surgery and Outcomes
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- Diet and metabolism studies
- Esophageal and GI Pathology
- Aortic Disease and Treatment Approaches
- Organ Transplantation Techniques and Outcomes
- Abdominal Surgery and Complications
- Liver Disease Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Cancer Immunotherapy and Biomarkers
- Transplantation: Methods and Outcomes
- Cytokine Signaling Pathways and Interactions
- Infectious Aortic and Vascular Conditions
- Immune Cell Function and Interaction
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Cardiovascular Disease and Adiposity
- Peripheral Artery Disease Management
- Obesity and Health Practices
- COVID-19 Clinical Research Studies
Universität Hamburg
2016-2025
University Medical Center Hamburg-Eppendorf
2016-2025
Eppendorf (Germany)
2019-2024
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2019
Martini-Klinik
2019
During metastasis, cancer cells invade, intravasate, enter the circulation, extravasate, and colonize target organs. Here, we examined role of interleukin (IL)-22 in metastasis. Immune cell-derived IL-22 acts on epithelial tissues, promoting regeneration healing upon tissue damage, but it is also associated with malignancy. Il22-deficient mice treated an antibody were protected from colon-cancer-derived liver lung metastasis formation, while overexpression promoted Mechanistically, acted...
Abstract Purpose The management of soft tissue sarcoma (STS) at reference centers with specialized multidisciplinary tumor boards (MTB) improves patient survival. German Cancer Society (DKG) certifies in German-speaking countries, promoting high standards care. This study investigated the variability treatment recommendations for localized STS across different tertiary centers. Methods In this cross-sectional case-based survey study, 5 anonymized cases imaging data were presented to MTBs 21...
Abstract Background Nonalcoholic fatty liver disease (NAFLD), especially nonalcoholic steatohepatitis (NASH) increases the risk for cirrhosis. Noninvasive tests NAFLD/NASH exist, but they are unreliable and thus biopsy remains standard diagnosis new noninvasive diagnostic approaches of great interest. The aim this study was to test whether serum levels acid-binding protein-4 (FABP4) matrix metalloproteinase-9 (MMP9) could be used as a tool NASH. Methods Patients who underwent bariatric...
Severe acute pancreatitis is an inflammatory disease of the pancreas with a high morbidity and mortality. To date, no causal treatment known. The aim present study was to analyze impact pancreatic microcirculatory disturbances in severe correlate effects histopathologic tissue damage outcome.Severe induced 129 pigs by injection glycodeoxycholic acid into duct. Pancreatic microcirculation, oxygenation, damage, survival were measured analyzed.Our demonstrates strong correlation between (r =...
A role of CD4+ T cells during the progression from nonalcoholic fatty liver disease (NAFLD) to steatohepatitis (NASH) has been suggested, but which polarization state these characterizes this and development fibrosis remain unclear. In addition, a gut-liver axis suggested play in NASH, just begun be investigated. Combining single-cell RNA sequencing multiple-parameter flow cytometry, we provide first cell atlas our knowledge focused on liver-infiltrating patients with NAFLD showing that NASH...
Abstract Background Bariatric surgery is the most effective treatment for patients with obesity. After surgery, lifelong follow-up care recommended to improve weight-loss outcomes. However, attendance low, and reasons have yet be determined. Therefore, present study aimed identify patients’ expectations perspectives on after bariatric current unmet needs ways increase attendance. Methods Patients who underwent at a university medical center attended least one appointment completed an online...
Background Due to increasing life expectancy and decreasing morbidity, society is aging. Especially the group of very old patients (≥90 years) currently significantly. This leads numbers requiring visceral thoracic surgery. However, due multimorbidity this cohort, postoperative intensive care often required. Currently, insufficient data are available regarding treatment therapy surgical critically ill patients. Therefore, study aimed investigate factors associated with early mortality...
Anastomotic leakage (AL) remains a prevalent and life-threatening complication after esophagectomy. Gastric tube perfusion assessment using indocyanine green fluorescence imaging (ICG-FI) has been published in several studies appears to be promising tool reduce AL rates by changing the surgical approach, namely an intraoperative evaluation of anastomosis localization.In this study, gastric was quantified ICG-FI 20 high-risk patients undergoing From time-dependent intensity curve, following...
Metastasis is a cancer-related systemic disease and responsible for the greatest mortality rate among cancer patients. Interestingly, interaction between immune system cells seems to play key role in metastasis formation target organ. However, this complex network only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 promotes cell extravasation, early step of metastasis. Based on these data, we aimed here decipher last formation. levels were increased...
Despite improvements in diagnosis, intensive-care medicine and surgical technique, the mortality of patients with secondary peritonitis is still high. Early aggressive empiric antibiotic treatment has strong impact on outcome. This retrospective study investigates bacterial fungal pathogens their sensitivity peritonitis. All that underwent emergency laparotomy due to at Department Surgery, University Medical Center Hamburg-Eppendorf between 2005 2015 were reviewed overall 414 included. We...
The objective was to evaluate cost-utility of bariatric surgery in Germany for a lifetime and 10-year horizon from health care payer perspective. State-transition Markov model provided absolute incremental clinical monetary results. In the model, obese patients could undergo surgery, develop post-surgery complications, experience diabetes type II, cardiovascular diseases or die. German Quality Assurance Bariatric Surgery Registry literature sources data on effectiveness safety. considered...
The intestine is constantly balancing the maintenance of a homeostatic microbiome and protection host against pathogens such as viruses. Many cytokines mediate protective inflammatory responses in intestine, among them IL-1β. IL-1β proinflammatory cytokine typically activated upon specific danger signals sensed by inflammasome. SARS-CoV-2 capable infecting multiple organs, including intestinal tract. Severe cases COVID-19 were shown to be associated with dysregulated immune response,...
Abstract Background Low socioeconomic status (SES) is associated with an increased prevalence of obesity. It unknown whether SES influences the outcome after bariatric surgery in Germany. Therefore, aim our study was to investigate linked inferior surgery. Methods We included all patients who underwent university hospital from 2012–2014. Net income estimated by matching zip codes patient residency region‐specific purchasing power index. analyzed relationship between SES, weight loss and...
Hepatocellular carcinoma (HCC) ranks among the five most common cancer entities worldwide and leads to hundred-thousands of deaths every year. Despite some groundbreaking therapeutical revelations during last years, overall prognosis remains poor. Although immune system fights malignant transformations with a robust anti-tumor response, certain mediators have also been shown promote development. For example, interleukin (IL)-22 has associated HCC progression worsened in multiple studies....
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus does not only lead to pulmonary infection but can also infect other organs such as gut, kidney, or liver. Recent studies confirmed that cases of COVID-19 are often associated with liver damage and failure, well systemic upregulation pro-inflammatory cytokines tumor necrosis factor-alpha (TNFα). However, impact these immune mediators in have on patient survival during...