A5047324759- Colorectal Cancer Surgical Treatments
- Esophageal Cancer Research and Treatment
- Anorectal Disease Treatments and Outcomes
- Colorectal and Anal Carcinomas
- Cytokine Signaling Pathways and Interactions
- Cancer Immunotherapy and Biomarkers
- Nutrition and Health in Aging
- Liver Disease and Transplantation
- Cancer, Hypoxia, and Metabolism
- Organ Transplantation Techniques and Outcomes
- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Anatomy and Medical Technology
- Colorectal Cancer Screening and Detection
- Diverticular Disease and Complications
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Lymphatic System and Diseases
- Surgical Simulation and Training
- Lung Cancer Research Studies
- Esophageal and GI Pathology
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- CAR-T cell therapy research
- Metabolism and Genetic Disorders
University Medical Center Hamburg-Eppendorf
2018-2024
Universität Hamburg
2018-2024
Praxis für Hämatologie und Onkologie
2004
During metastasis, cancer cells invade, intravasate, enter the circulation, extravasate, and colonize target organs. Here, we examined role of interleukin (IL)-22 in metastasis. Immune cell-derived IL-22 acts on epithelial tissues, promoting regeneration healing upon tissue damage, but it is also associated with malignancy. Il22-deficient mice treated an antibody were protected from colon-cancer-derived liver lung metastasis formation, while overexpression promoted Mechanistically, acted...
Gastrin receptor scintigraphy (GRS) is a new imaging method primarily developed for the detection of metastases medullary thyroid carcinoma (MTC). As gastrin-binding CCK 2 receptors are also expressed on variety other neuroendocrine tumours (NET), we compared GRS to somatostatin (SRS) in patients with NET. SRS and were performed within 21 days series 60 consecutive was directly SRS. If lesions visible but not detectable by SRS, modalities (MRI, CT) follow-up used verification. Of evaluable...
Cirrhosis is associated with an increased surgical morbidity and mortality. Portal hypertension the surgery type have been established as critical determinants of postoperative outcome. We aim to evaluate hypothesis that preoperative transjugular intrahepatic portosystemic shunt (TIPS) placement in patients cirrhosis a lower incidence in-house mortality/liver transplantation (LT) after surgery.A retrospective database search for years 2010-2020 was carried out. identified 64 who underwent...
Abstract Purpose Improved long-term survival after low anterior resection (LAR) for rectal cancer highlights the importance of functional outcome. Urogenital and anorectal dysfunction is frequently reported conventional LAR. Advanced minimally invasive techniques such as robotic (RoTME) transanal total mesorectal excision (TaTME) might improve results by precisely dissecting preserving autonomic nerves. We compared outcomes RoTME or TaTME in a multicenter study. Methods One hundred twenty...
Metastasis is a cancer-related systemic disease and responsible for the greatest mortality rate among cancer patients. Interestingly, interaction between immune system cells seems to play key role in metastasis formation target organ. However, this complex network only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 promotes cell extravasation, early step of metastasis. Based on these data, we aimed here decipher last formation. levels were increased...
Abstract Colorectal carcinoma (CRC) is one of the most common carcinomas worldwide. Early detection crucial for reducing morbidity and mortality. Several promising studies described use midkine (MK) as a tumor marker. This study aimed to investigate larger collective ascertain if preoperative serum level (S‐MK) suitable marker screening S‐MK correlates with progression localization. It was also investigated first time whether patients high show poor survival. prospective single‐center...
MALT1 is a key mediator of NF-κB signaling and main driver B-cell lymphomas. Remarkably, expressed in the majority pancreatic ductal adenocarcinomas (PDACs) as well, but absent from normal exocrine tissue. Following, shows off to be specific target cancer cells PDAC without affecting regular cells. Therefore, we studied impact pharmacological inhibition showed promising effects on tumor progression. Mepazine (Mep), phenothiazine derivative, known potent inhibitor. Newly, described that...
Hepatocellular carcinoma (HCC) ranks among the five most common cancer entities worldwide and leads to hundred-thousands of deaths every year. Despite some groundbreaking therapeutical revelations during last years, overall prognosis remains poor. Although immune system fights malignant transformations with a robust anti-tumor response, certain mediators have also been shown promote development. For example, interleukin (IL)-22 has associated HCC progression worsened in multiple studies....
The role of CD10 expression in colorectal cancer has been controversially discussed the literature. Some data suggest a predictive capacity for lymph node and liver metastases, thus influencing overall survival (OS) disease-free (DFS). This study aims to analyse relationship between European cohort. To determine association with tumour phenotype, molecular features, prognosis, tissue microarray 1469 carcinomas was analysed using immunohistochemistry compared matched clinicopathologic data....
Abstract Purpose To define the best possible outcomes for robotic-assisted low anterior rectum resection (RLAR) using total mesorectal excision (TME) in low-morbid patients, performed by expert robotic surgeons German centers. The benchmark values were derived from these results. Methods data was retrospectively collected five After patient exclusion (prior surgery, extended no prior anastomosis, hand-sewn anastomosis), cohort defined (n = 226). median with interquartile range first...
Respiratory–digestive tract fistulas are fatal complications that occur in esophageal cancer treatment. Interdisciplinary treatment strategies still evolving, especially anatomical stratification. Thus, this study aims to evaluate general therapeutic for rare condition. Medical records were reviewed cancer-associated respiratory–digestive fistula patients treated between January 2008 and September 2021. Fistulas classified according being surgery- tumor-associated. Treatment strategies,...
Concomitant liver cirrhosis is a crucial risk factor for major surgeries. However, only few data are available concerning cirrhotic patients requiring esophagectomy malignant disease.From prospectively maintained database of esophageal cancer patients, who underwent curative between 01/2012 and 01/2016, with concomitant (liver-cirrhotic LCP) were compared to non-liver-cirrhotic (NLCP).Of 170 14 predominately low MELD scores (≤ 9, 64.3%) identified. Perioperative outcome was significantly...
In Germany, socioeconomically deprived citizens more often develop esophageal carcinoma, since typical risk factors follow the social gradient. Therefore, we hypothesized that socioeconomic deprivation might also be associated with advanced tumor stages and comorbidities at time of surgery. As a consequence, may related to postoperative complications reduced overall survival. 310 patients who had undergone esophagectomy for cancer in curative intent between 2012 2020 University Medical...
The immune system plays a pivotal role in cancer progression. Interleukin 22 binding protein (IL-22BP), natural antagonist of the cytokine interleukin (IL-22) has been shown to control progression colorectal (CRC). However, IL-22BP process metastasis formation remains unknown.We used two different murine vivo models using MC38 and LLC cell lines studied lung liver after intracaecal or intrasplenic injection cells. Furthermore, IL22BP expression was measured clinical cohort CRC patients...
Künstliche-Intelligenz-Tools sind das Hype-Thema der Stunde und bereits im Alltag vieler Menschen angekommen. Auch in Medizin gibt es rasante Entwicklungen technischen Innovationsbereich mit dem Potenzial, den Arbeitsalltag auch von Chirurginnen Chirurgen grundlegend zu verändern. Zahlreiche Anwendungsmöglichkeiten, die bis vor Kurzem noch undenkbar waren, versprechen eine Verbesserung Patientenversorgung bei effizienterer Nutzung zur Verfügung stehenden Ressourcen. Allerdings bisher kaum...
Background: Whenever possible, treatment of breast cancer should be performed in an outpatient setting, but only few data about patients being treated exclusively on basis are available. Patients and Methods: A retrospective analysis was 90 unselected who were consecutively our oncology group practice between 6/95 8/99. Results: Median age at detection metastases 55 years (30–90) performance status ranged from 0 to 2. 83 (92.2%) received chemotherapy, 7 (7.8%) endocrine therapy only. CMF...
Neben der erhofften Verbesserung des Behandlungsergebnisses durch gesetzliche Mindestmengen und Zertifizierungen onkologischen Viszeralchirurgie sind auch negative Effekte für Patienten Behandler zu erwarten. Vor diesem Hintergrund soll in Beitrag die Evidenzlage von Pankreas-, Ösophagus- Kolorektalchirurgie dargestellt anschließend auf Kritikpunkte an zunehmenden Zentrumsbildung Lösungsansätze eingegangen werden.
Abstract Background Prolyl hydroxylase 1 (PHD1) is a prognostic marker in several cancers. Aims and scopes: This study was undertaken to elucidate the clinical relevance of PHD1 colorectal cancer (CRC) prognosis. Materials methods We compared expression on tissue microarray (TMA) containing samples from 1800 CRCs with corresponding clinicopathological tumor variables patient survival. Results While staining always high benign epithelium, detectable only 71.8% CRCs. Low associated advanced...
Fragestellung Patienten mit Leberzirrhose weisen eine erhöhte postoperative Mortalität auf. Ob die Senkung der portalen Hypertension durch TIPS-Anlage einen Effekt auf das Outcome hat, ist unklar.
Abstract Background Prolyl hydroxylase 1 (PHD1) is a prognostic marker in several cancers. Aims and scopes This study was undertaken to elucidate the clinical relevance of PHD1 colorectal cancer (CRC) prognosis. Materials methods We compared expression on tissue microarray (TMA) containing samples from 1800 CRCs with corresponding clinicopathological tumor variables patient survival. Results While staining always high benign epithelium, detectable only 71.8% CRCs. Low associated advanced...