A5044376789- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Cancer, Stress, Anesthesia, and Immune Response
- Migration and Labor Dynamics
- Hepatitis C virus research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Animal Virus Infections Studies
- Hepatitis B Virus Studies
- Viral Infections and Immunology Research
- Liver Diseases and Immunity
- Sex work and related issues
- Cancer therapeutics and mechanisms
- Parvovirus B19 Infection Studies
- Cell death mechanisms and regulation
- Viral-associated cancers and disorders
- Synthesis and biological activity
- NF-κB Signaling Pathways
University Medical Center Hamburg-Eppendorf
2016-2025
Universität Hamburg
2016-2025
Abstract Background and aims Hepatitis E virus (HEV), similar to hepatitis A (HAV), has been linked cases associated with mussel consumption, several studies have detected HEV in commercially available mussels. While extensive data exists on contamination mussels from tropical regions, the Mediterranean Sea, North there is a lack of information regarding potential risk posed by common ( Mytilidae ) Baltic Sea. Furthermore, no experimental investigated ability Sea be infected HEV. Material...
MALT1 is a key mediator of NF-κB signaling and main driver B-cell lymphomas. Remarkably, expressed in the majority pancreatic ductal adenocarcinomas (PDACs) as well, but absent from normal exocrine tissue. Following, shows off to be specific target cancer cells PDAC without affecting regular cells. Therefore, we studied impact pharmacological inhibition showed promising effects on tumor progression. Mepazine (Mep), phenothiazine derivative, known potent inhibitor. Newly, described that...
Hepatitis E virus (HEV) genotype 3 infections in Germany are mainly transmitted zoonotically through the consumption of swine meat. Furthermore, there is evidence that pets might come into contact with HEV, but relevance companion animals as possible sources HEV transmission still needs to be defined. A monitoring study was therefore carried out on dogs, cats, and horses from Germany. In total 365 serum samples (124 119 122 horses) were tested for by PCR anti-HEV antibodies a commercial...
While the sexual transmissibility of HAV in MSM has been extensively described, potential for transmission HEV not definitively established. Although detected ejaculate chronically infected men, studies among PrEP users France did observe an elevated anti-HEV seroprevalence as indicator increased exposure risk by intercourse. A total 111 unselected and age- sex-matched blood donors were tested IgG, IgM (PCR). Of participants 79/111 (71 %) responded to a questionnaire covering topics...
e14075 Background: Mucosa-associated lymphoid tissue lymphoma translocation protein-1 (MALT1) is a key mediator of NF-kB signaling and crucial for proliferation anti-apoptosis in B-cell lymphomas. Mepazine (MEP) phenothiazine derivative potent MALT1 inhibitor. Biperiden (BIP) competitive receptor substrate Phenotiazines. There little data on the role pancreatic ductal adenocarcinomas (PDAC). Methods: expression was analyzed by IHC 310 patients with PDAC. In silico docking performed to...
Background Hepatitis E virus (HEV) genotype 3 infections in Germany are mainly transmitted zoonotically by consumption of swine meat. Furthermore, there is evidence that pets might get contact with HEV but the relevance as possible hosts still needs to be defined.