A5073903072- Vector-borne infectious diseases
- Viral Infections and Vectors
- Blood groups and transfusion
- Veterinary Medicine and Surgery
- Veterinary Oncology Research
- Platelet Disorders and Treatments
- Vector-Borne Animal Diseases
- Rabies epidemiology and control
- Veterinary Equine Medical Research
- Microbial infections and disease research
- Leptospirosis research and findings
- Dermatological diseases and infestations
- Blood transfusion and management
- Streptococcal Infections and Treatments
- Erythrocyte Function and Pathophysiology
- Antimicrobial Resistance in Staphylococcus
- Immune Response and Inflammation
- Zoonotic diseases and public health
- Animal health and immunology
- Virus-based gene therapy research
- Thyroid Disorders and Treatments
- Hemoglobinopathies and Related Disorders
- Human-Animal Interaction Studies
- Veterinary Orthopedics and Neurology
- Viral gastroenteritis research and epidemiology
Freie Universität Berlin
2016-2025
Deutscher Bundestag
2015
University of Veterinary Medicine Hannover, Foundation
2008-2014
University of Potsdam
2010-2012
German Red Cross
2012
Helmholtz Centre for Environmental Research
2012
Fraunhofer Institute for Cell Therapy and Immunology
2012
Zimmer Biomet (Germany)
2011
German Institute of Human Nutrition
2011
Gesellschaft zur Förderung angewandter Informatik
2010
There is a high mortality rate in patients with systemic inflammatory response syndrome (SIRS) or sepsis. Therefore, an early diagnosis and prognostic assessment important for optimal therapeutic intervention. The objective of the study was to evaluate if baseline values changes serum C-reactive protein (CRP) might predict survival dogs SIRS sepsis.Prospective study; July 2004 2005.Small Animal Clinic, Berlin, Clinic Small Medicine, Munich.Sixty-one dogs.For CRP analysis blood drawn on day...
Background Chronic diarrhea ( CD ) is common in dogs, and information on frequency distribution of primary secondary causes lacking. Objectives To evaluate underlying predictors outcome dogs with . Animals One hundred thirty‐six client‐owned (≥3 weeks duration). Methods Retrospective review medical records (Small Animal Clinic, Freie Universität Berlin, Germany, 09/2009‐07/2011). Quantification final diagnoses comparison clinical aspects including disease severity clinicopathological...
Dogs are the main reservoir of Leishmania infantum and in some countries have been regularly culled as part government policy to control visceral leishmaniasis. At 13th Symposium Companion Vector-Borne Diseases World Forum Windsor, UK, March 19-22, 2018, we consolidated a consensus statement regarding usefulness dog culling means controlling The highlighted futility infected dogs, whether healthy or sick, measure domestic L. reduce risk for
Background: Anaplasma phagocytophilum , the causative agent of canine granulocytic anaplasmosis (CGA), is a Gram‐negative intracellular organism transmitted by ixodid ticks. Thus far, only few clinical studies evaluating dogs with CGA have been published. Objectives: Evaluation naturally infected A. in which known co‐infections were excluded. Animals: Eighteen CGA. Methods: Prospective study. The diagnosis was based on positive PCR test result; History, findings, CBC, biochemistry,...
Background: Leptospirosis in dogs is a multiorgan disease affecting mostly kidneys and liver. Objectives: The objective was to characterize prevalence, clinical, radiological features outcome of with leptospirosis pulmonary abnormalities. Animals: Fifty leptospirosis. Methods: Medical records diagnosed at the Small Animal Clinic, Berlin, were reviewed. Diagnosis based on microscopic agglutination test, blood or urine polymerase chain reaction, histopathology. Based clinical and/or signs,...
Tick-borne diseases are a major health risk for humans and dogs. In addition to collection analysis of questing ticks, host-associated ticks the presence pathogens is valuable method gain insight into transmission patterns tick-borne diseases.Ticks were collected from dogs living in Berlin/Brandenburg area. The three tick species Ixodes ricinus, hexagonus Dermacentor reticulatus examined Babesia spp., Borrelia Rickettsia spp. Anaplasmataceae. Conventional PCR followed by sequencing was used...
Abstract Immune thrombocytopenia (ITP) is the most common acquired primary hemostatic disorder in dogs. less commonly affects cats but an important cause of mortality and treatment‐associated morbidity both species. remains a diagnosis exclusion for which diagnostic guidelines are lacking. Primary, or non‐associative, ITP refers to autoimmune platelet destruction. Secondary, associative, arises response underlying disease trigger. However, evidence comorbidities serve as triggers has not...
This survey assessed the feline transfusion practices at University of Berlin from 1998 to 2001 in regard patient population, indications, efficacy, and reactions. Blood was obtained seven healthy in-house donors 127 mostly indoor client-owned pet cats. Over a 3-year period 91 cats were transfused with blood type compatible blood. The fresh (within 8 h collection) or stored no longer than 15 days. Transfusions required because loss anaemia ( n=40), haemolytic n=13), ineffective...
During a 6-year period, primary (idiopathic) immune-mediated thrombocytopenia was retrospectively evaluated in 30 dogs. Ages of the dogs ranged from 3 months to 10 years (median 4 years); female were markedly overrepresented with 73%. Clinical examination revealed hemorrhages 70% Platelet counts 0 111,000/μL 8000/μL); 77% had platelet <30,000/μL. Seventeen anemic (hematocrit 9% 36%; median 31%). Immunosuppressive therapy performed all but one dog. The recurrence rate 19 that followed...
Abstract Methicillin-resistant Staphylocoocus aureus (MRSA) harboring mecALGA251 has been isolated from humans and ruminants. Database screening identified this MRSA variant in cats, dogs, a guinea pig Germany during 2008–2011. The novel is not restricted to ruminants or humans, contact with companion animals might pose zoonotic risk.
Anaplasma phagocytophilum is an obligate intracellular bacterium that causes granulocytic anaplasmosis in domestic animals, wildlife, and humans primarily transmitted by ticks of the Ixodes persulcatus complex. This retrospective study aims to determine percentages dogs tested positive for A. Germany. It included results direct (polymerase chain reaction [PCR]) indirect (immunofluorescence antibody test [IFAT], antibody-enzyme-linked immunosorbent assay [ELISA]) detection methods performed...
Immune-mediated hemolytic anemia (IMHA) occurs less frequently in cats than dogs. The value of the Coombs' test (CT) has been questioned, but detailed surveys its use are lacking. objective this study was to describe 19 with primary IMHA (pIMHA) and examine diagnostic direct CT. CT performed 92 cats; it negative 5 healthy, 9 sick nonanemic, 55 different types anemia. positive 18 anemic (2 feline leukemia virus (FeLV) positive, 1 cholangiohepatitis, 15 no underlying disease). Moreover,...
Sepsis is still a major cause of death in both human and veterinary medicine. Early diagnosis essential for appropriate treatment. Identification patients at risk developing sepsis already possible medicine through the measurement plasma interleukin-6 (IL-6) levels. In medicine, however, this has been investigated only canine experimental models.The purpose study was to measure IL-6 levels dogs with naturally occurring systemic inflammatory response syndrome (SIRS) analyze value as...
Immune‐mediated hemolytic anemia (IMHA) occurs less frequently in cats than dogs. The value of the Coombs' test (CT) has been questioned, but detailed surveys its use are lacking. objective this study was to describe 19 with primary IMHA (pIMHA) and examine diagnostic direct CT. CT performed 92 cats; it negative 5 healthy, 9 sick nonanemic, 55 different types anemia. positive 18 anemic (2 feline leukemia virus (FeLV) positive, 1 cholangiohepatitis, 15 no underlying disease). Moreover,...
Abstract Objective —To compare response rates and remission survival times in dogs with lymphoma treated a continuous, multiagent, doxorubicin-based chemotherapeutic protocol or short-term single-agent incorporating doxorubicin. Design —Nonrandomized controlled clinical trial. Animals —114 lymphoma. Procedures —Dogs were consisting of L-asparaginase, vincristine, cyclophosphamide, doxorubicin, methotrexate, prednisolone (n = 87) doxorubicin alone (27). Results —63 86 (73%) the multiagent...
Canine primary immune-mediated hemolytic anemia (IMHA) is associated with a high-mortality rate. C-reactive protein (CRP) the most important acute-phase in dogs and may have value as marker of prognosis or response to treatment IMHA.The objectives this study were evaluate serum CRP concentration IMHA at presentation during treatment, assess potential differences based on survival time, compare other laboratory parameters inflammation prognosis.Inclusion criteria for (PCV<0.30 L/L), positive...
ABSTRACT “ Candidatus Neoehrlichia mikurensis” ( Anaplasmataceae ) is an emerging pathogen transmitted by Ixodes ticks. Conventional PCR and the newly developed high-resolution melt were used to detect discriminate Anaplasma phagocytophilum . Both bacterial species frequently found in ricinus hexagonus but virtually absent from Dermacentor reticulatus In rodents, N. was significantly more prevalent than A. , whereas cats, only found.