A5038248038- Organ Transplantation Techniques and Outcomes
- Clinical Nutrition and Gastroenterology
- Cardiac Ischemia and Reperfusion
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Anesthesia and Neurotoxicity Research
- Metabolism and Genetic Disorders
- Veterinary Pharmacology and Anesthesia
- Liver Disease and Transplantation
- Diet and metabolism studies
- Mechanical Circulatory Support Devices
- Electrolyte and hormonal disorders
- Nerve injury and regeneration
- Peripheral Nerve Disorders
- Gastrointestinal motility and disorders
- Nerve Injury and Rehabilitation
- Fatty Acid Research and Health
- Immune Cell Function and Interaction
- Animal testing and alternatives
- Pharmacological Effects and Toxicity Studies
- Pancreatic function and diabetes
- Cholesterol and Lipid Metabolism
- Surgical Simulation and Training
- Antibiotics Pharmacokinetics and Efficacy
- Pregnancy and Medication Impact
Universidad Nacional de La Plata
2013-2024
Fundacion Favaloro Hospital Universitario
2013-2023
Favaloro Foundation
2016
Favaloro University
2011-2012
Biochemistry Research Institute of La Plata
2007-2009
Consejo Nacional de Investigaciones Científicas y Técnicas
2007
Argerich Hospital
2004
Metastasis is a cancer-related systemic disease and responsible for the greatest mortality rate among cancer patients. Interestingly, interaction between immune system cells seems to play key role in metastasis formation target organ. However, this complex network only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 promotes cell extravasation, early step of metastasis. Based on these data, we aimed here decipher last formation. levels were increased...
Silastic tubes are used as training material for performing microvascular anastomoses. However, silastic texture differs from that of actual blood vessels. In the present work, we evaluate use preserved rat arterial segments in One-centimeter-long were obtained femoral, carotid, and abdominal arteries, cold saline solution, frozen. Trainees performed anastomoses using aforementioned answered questions about texture, consistency, wall resistance to needle, comparing tubes. They also asked...
Summary Reperfusion injury remains one of the major problems in transplantation. Repair from ischaemic acute renal failure (ARF) involves stimulation tubular epithelial cell proliferation. The aim this exploratory study was to evaluate effects preconditioning donor animals with rapamycin and tacrolimus prevent ischaemia–reperfusion (I/R) injury. Twelve hours before nephrectomy, received immunosuppressive drugs. were divided into four groups, as follows: group 1 control: no treatment; 2: (2...
There is an urgent need to address the shortage of potential multivisceral grafts in order reduce average time waiting list. Since donation after circulatory death (DCD) has been successfully employed for other solid organs, a thorough evaluation use intestinal from DCD warranted. Here, we have generated model Maastricht III rodents, focusing on viability and at five (DCD5) twenty (DCD20) minutes cardiac arrest compared living brain donors. groups exhibited time-dependent damage. DCD20...
Background Intestinal transplantation (ITx) faces many challenges due to the complexity of surgery and multiple immunological reactions that lead necessity rigorous follow-up for early detection acute cellular rejection (ACR). Our aim was determine kinetics ACR using an experimental ITx model, with emphasis in characterization process different approaches, including use functional assays absorptive barrier function. Methods rats conducting serial sampling performed. Clinical monitoring,...
Organ transplantation is the treatment of choice against terminal and irreversible organ failure. Optimal preservation graft crucial to counteract cold ischemia effects. As we developed an N , ‐bis‐2‐hydroxyethyl‐2‐aminoethanesulfonic acid–gluconate–polyethylene glycol (BGP)–based solution (hypothermic machine perfusion [HMP]), aimed analyze use this on static storage (SCS) rat livers for as compared with histidine tryptophan ketoglutarate (HTK) solution. Livers procured from adult male...
Epineural stitches are a means to avoid tension in nerve suture. We evaluate this technique, relative interposed grafts and simple neurorraphy, rat model.Twenty rats were allocated four groups. For Group 1, sectioning of the sciatic was performed, segment 4 mm long discarded, epineural suture with distal anchoring placed resulting slight neurorraphy. 2, neurorraphy performed. 3, graft employed served as control. Ninety days after, reoperation, latency motor action potentials recording axonal...
BACKGROUND The hemodynamic maintenance of brain-dead donors will influence the quality organs procured for transplantation, including intestine. Although norepinephrine (NE) and dopamine (DA) are commonly used to sustain mean arterial pressure in humans, there no standardized protocols their use during donors. Our aim was compare effects each drug, intestinal graft using a rat donation model. METHODS Wistar rats (N = 17) underwent brain death (BD) 2 hours with NE (NE group) or DA (DA...
Intestinal transplantation (IT) faces many challenges, among them, the necessity to early detect rejection processes. Rodent models of IT are used provide evidence for intervention strategies as well improve knowledge small bowel transplant biology. The aim our study was determine kinetics using a Heterotopic (HIT) model, with emphasis in characterization process different approaches, including use simple functional assays absorptive and barrier function evaluation that could be eventually...