A5036000854- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Bariatric Surgery and Outcomes
- Diabetes Treatment and Management
- Liver Diseases and Immunity
- Esophageal Cancer Research and Treatment
- Metabolism, Diabetes, and Cancer
- Pharmacology and Obesity Treatment
- Nuclear Receptors and Signaling
- Neurological disorders and treatments
- Obesity and Health Practices
- Esophageal and GI Pathology
- Apelin-related biomedical research
- Immune Cell Function and Interaction
- Parkinson's Disease Mechanisms and Treatments
- Macrophage Migration Inhibitory Factor
- Immune cells in cancer
- Abdominal Surgery and Complications
- Lipid metabolism and biosynthesis
- Intraperitoneal and Appendiceal Malignancies
- Peroxisome Proliferator-Activated Receptors
- Liver physiology and pathology
- Appendicitis Diagnosis and Management
University Medical Center Hamburg-Eppendorf
2020-2025
Universität Hamburg
2020-2025
LMU Klinikum
2021-2025
Ludwig-Maximilians-Universität München
2021-2025
Universidade Estadual de Campinas (UNICAMP)
2023
Technical University of Munich
2023
University of Augsburg
2023
University of Salzburg
2023
Yale University
2023
Institute of Molecular and Cell Biology
2023
Abstract Purpose About 20–25% of patients experience weight regain (WR) or insufficient loss (IWL) after bariatric metabolic surgery (BS). Therefore, we aimed to retrospectively assess the effectiveness adjunct treatment with GLP-1 receptor agonist semaglutide in non-diabetic WR IWL BS. Materials and Methods Post-bariatric without type 2 diabetes (T2D) ( n = 44) were included analysis. The primary endpoint was 3 6 months initiation treatment. Secondary endpoints change BMI, HbA1c, lipid...
During metastasis, cancer cells invade, intravasate, enter the circulation, extravasate, and colonize target organs. Here, we examined role of interleukin (IL)-22 in metastasis. Immune cell-derived IL-22 acts on epithelial tissues, promoting regeneration healing upon tissue damage, but it is also associated with malignancy. Il22-deficient mice treated an antibody were protected from colon-cancer-derived liver lung metastasis formation, while overexpression promoted Mechanistically, acted...
Summary About 20%–25% of patients experience weight regain (WR) or insufficient loss (IWL) following bariatric surgery (BS). Therefore, we aimed to retrospectively assess the effectiveness adjunct treatment with semaglutide in without type 2 diabetes (T2D) post‐bariatric failure over a 12 months period. Post‐bariatric T2D WR IWL ( n = 29) were included analysis. The primary endpoint was after initiation treatment. Secondary endpoints change body mass index, HbA1c, lipid profile, high...
Abstract Background Nonalcoholic fatty liver disease (NAFLD), especially nonalcoholic steatohepatitis (NASH) increases the risk for cirrhosis. Noninvasive tests NAFLD/NASH exist, but they are unreliable and thus biopsy remains standard diagnosis new noninvasive diagnostic approaches of great interest. The aim this study was to test whether serum levels acid-binding protein-4 (FABP4) matrix metalloproteinase-9 (MMP9) could be used as a tool NASH. Methods Patients who underwent bariatric...
Abstract The parkinsonian gait disorder and freezing of are therapeutically demanding symptoms with considerable impact on quality life. aim this study was to assess the role subthalamic nigral neurons in control using intraoperative microelectrode recordings basal ganglia during a supine stepping task. Twelve male patients (56 ± 7 years) suffering from moderate idiopathic Parkinson’s disease (disease duration 10 3 years, Hoehn Yahr stage 2), undergoing awake neurosurgery for deep brain...
A role of CD4+ T cells during the progression from nonalcoholic fatty liver disease (NAFLD) to steatohepatitis (NASH) has been suggested, but which polarization state these characterizes this and development fibrosis remain unclear. In addition, a gut-liver axis suggested play in NASH, just begun be investigated. Combining single-cell RNA sequencing multiple-parameter flow cytometry, we provide first cell atlas our knowledge focused on liver-infiltrating patients with NAFLD showing that NASH...
Abstract Background Bariatric surgery is the most effective treatment for patients with obesity. After surgery, lifelong follow-up care recommended to improve weight-loss outcomes. However, attendance low, and reasons have yet be determined. Therefore, present study aimed identify patients’ expectations perspectives on after bariatric current unmet needs ways increase attendance. Methods Patients who underwent at a university medical center attended least one appointment completed an online...
•IL-17 induces the expression of PD-L1 in mouse and human cholangiocytes.•CD8+ T cell-derived IL-17 on antigen-presenting cholangiocytes.•PD-L1 by cholangiocytes restricts expansion self-reactive cells experimental cholangitis.•Caution may be warranted using broad neutralisation for treatment cell-mediated cholangitis. Background & AimsIL-17A-producing are present autoimmune cholestatic liver diseases; however, little is known about contribution to periductal immune responses. Herein, we...
Anastomotic leakage (AL) remains a prevalent and life-threatening complication after esophagectomy. Gastric tube perfusion assessment using indocyanine green fluorescence imaging (ICG-FI) has been published in several studies appears to be promising tool reduce AL rates by changing the surgical approach, namely an intraoperative evaluation of anastomosis localization.In this study, gastric was quantified ICG-FI 20 high-risk patients undergoing From time-dependent intensity curve, following...
Abstract Atherosclerosis is the underlying cause of myocardial infarction and ischemic stroke. It a lipid-triggered cytokine/chemokine-driven arterial inflammatory condition. We identify D-dopachrome tautomerase/macrophage migration-inhibitory factor-2 (MIF-2), paralog cytokine MIF, as an atypical chemokine promoting both atherosclerosis hepatic lipid accumulation. In hyperlipidemic Apoe –/– mice, Mif-2 -deficiency pharmacological MIF-2-blockade protect against lesion formation vascular...
Background: The development of obesity-associated comorbidities such as type 2 diabetes (T2D) and hepatic steatosis has been linked to selected microRNAs in individual studies; however, an unbiased genome-wide approach map T2D induced changes the miRNAs landscape human liver samples, a subsequent robust identification validation target genes are still missing. Methods: Liver biopsies from age- gender-matched obese individuals with (n=20) or without were used for microRNA microarray analysis....
Background Freezing of gait (FoG) is a disabling burden for Parkinson’s disease (PD) patients with poor response to conventional therapies. Combined deep brain stimulation the subthalamic nucleus and substantia nigra (STN+SN DBS) moved into focus as potential therapeutic option treat parkinsonian disorder refractory FoG. The mechanisms action DBS within cortical-subcortical-basal ganglia network on gait, particularly at cortical level, remain unclear. Methods Twelve idiopathic PD...
Abstract Background Low socioeconomic status (SES) is associated with an increased prevalence of obesity. It unknown whether SES influences the outcome after bariatric surgery in Germany. Therefore, aim our study was to investigate linked inferior surgery. Methods We included all patients who underwent university hospital from 2012–2014. Net income estimated by matching zip codes patient residency region‐specific purchasing power index. analyzed relationship between SES, weight loss and...
De novo lipogenesis (DNL) in visceral adipose tissue (VAT) is associated with systemic insulin sensitivity. DNL VAT regulated through ChREBP activity and glucose uptake Glut4 (encoded by Slc2a4). Slc2a4 expression, activity, are decreased obesity, the underlying cause however remains unidentified. We hypothesize that increased DNA methylation an enhancer region of decreases expression obesity resistance. found SLC2A4 morbidly obese subjects high HbA1c (>6.5%, n = 35) decreased, whereas...
Abstract Purpose Venous thromboembolic events (VTEs) are common complications after bariatric surgery, and enoxaparin is commonly used to prevent VTEs. The risk for VTEs sex-specific. Whether application results in similar anti-factor Xa activities (aFXa) males females with obesity remains be determined. We investigated whether our dosage regimen of resulted serum aFXa levels female male patients undergoing surgery. Materials Methods administered twice daily Patients a body mass index (BMI)...
Abstract Background Bariatric-metabolic surgery (BS) decreases the grade of steatosis, hepatic inflammation, and fibrosis in patients with severe obesity non-alcoholic fatty liver disease (NAFLD). Mechanisms include substantial weight loss, but also simultaneous effects on glucose homeostasis. Therefore, we aimed to investigate association between NAFLD remission type 2 diabetes (T2D) up 8 years following different types BS. Methods In a retrospective cohort study including 107 T2D at...
Background: The development of obesity-associated comorbidities such as type 2 diabetes (T2D) and hepatic steatosis has been linked to selected microRNAs in individual studies; however, an unbiased genome-wide approach map T2D induced changes the miRNAs landscape human liver samples, a subsequent robust identification validation target genes are still missing. Methods: Liver biopsies from age- gender-matched obese individuals with (n=20) or without were used for microRNA microarray analysis....
Abstract Background Hematologic patients requiring abdominal emergency surgery are considered to be a high-risk population based on disease- and treatment-related immunosuppression. However, the optimal surgical therapy perioperative management of with in coexisting hematological malignancies remain unclear. Methods We here report single-center retrospective analysis aimed investigate impact due clinically suspected gastrointestinal perforation (group A), intestinal obstruction B), or acute...
SUMMARY Atherosclerosis is the underlying cause of cardiovascular diseases (CVDs) such as myocardial infarction and ischemic stroke. It a lipid-triggered chronic inflammatory condition arterial vascular wall that driven by various pathways including atherogenic cytokines chemokines. D-dopachrome tautomerase (D-DT), also known macrophage migration inhibitory factor-2 (MIF-2), belongs to MIF protein family, which best for its pathogenic role in variety immune conditions CVDs. While well...
In Germany, socioeconomically deprived citizens more often develop esophageal carcinoma, since typical risk factors follow the social gradient. Therefore, we hypothesized that socioeconomic deprivation might also be associated with advanced tumor stages and comorbidities at time of surgery. As a consequence, may related to postoperative complications reduced overall survival. 310 patients who had undergone esophagectomy for cancer in curative intent between 2012 2020 University Medical...
The development of obesity-associated comorbidities such as type 2 diabetes (T2D) and hepatic steatosis has been linked to selected microRNAs in individual studies; however, an unbiased genome-wide approach map T2D induced changes the miRNAs landscape human liver samples, a subsequent robust identification validation target genes is still missing.Liver biopsies from age- gender-matched obese individuals with (n=20) or without were used for microRNA microarray analysis. candidate validated 85...