A5115599142- Diet and metabolism studies
- Diabetes Treatment and Management
- Diabetes Management and Research
- Pharmacology and Obesity Treatment
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Bariatric Surgery and Outcomes
- Circadian rhythm and melatonin
- Retinal Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Diet, Metabolism, and Disease
- Dietary Effects on Health
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Sleep and Wakefulness Research
- Endoplasmic Reticulum Stress and Disease
- Sleep and related disorders
- Spectroscopy Techniques in Biomedical and Chemical Research
- Regulation of Appetite and Obesity
- Metabolism and Genetic Disorders
- Non-Invasive Vital Sign Monitoring
- Nutrition, Genetics, and Disease
University of Lübeck
2018-2025
University Hospital Schleswig-Holstein
2018-2025
German Center for Diabetes Research
2019-2024
Heinrich Heine University Düsseldorf
2019-2024
Deutsches Diabetes-Zentrum e.V.
2019-2024
Universitäres Kinderwunschzentrum Lübeck
2024
Abstract Purpose About 20–25% of patients experience weight regain (WR) or insufficient loss (IWL) after bariatric metabolic surgery (BS). Therefore, we aimed to retrospectively assess the effectiveness adjunct treatment with GLP-1 receptor agonist semaglutide in non-diabetic WR IWL BS. Materials and Methods Post-bariatric without type 2 diabetes (T2D) ( n = 44) were included analysis. The primary endpoint was 3 6 months initiation treatment. Secondary endpoints change BMI, HbA1c, lipid...
Hypoglycemia is a particular problem in people with diabetes while it can also occur other clinical circumstances. unawareness describes condition which autonomic and neuroglycopenic symptoms of hypoglycemia decrease hence are hardly perceivable. A failure to recognize time lead unconsciousness, seizure, even death. The risk factors include intensive glycemic control, prior episodes severe hypoglycemia, long duration diabetes, alcohol consumption, exercise, renal failure, sepsis....
Key points The Anrep effect represents the alteration of left ventricular (LV) contractility to acutely enhanced afterload in a few seconds, thereby preserving stroke volume (SV) at constant preload. As result missing preload stretch our model, differs from slow force response and has different mechanism. demonstrated two phases. First, sudden increased was momentary equilibrated by LV as higher power strokes strongly‐bound myosin cross‐bridges. Second, slightly delayed recovery SV is...
There is evidence that reduced sleep duration increases hunger, appetite, and food intake, leading to metabolic diseases, such as type 2 diabetes obesity. However, the impact of timing, irrespective its on regulation hunger less clear. We aimed evaluate loss during late vs. early part night desire for food.Fifteen normal-weight ([mean ± SEM] body-mass index: 23.3 0.4 kg/m2) healthy men were studied in a randomized, balanced, crossover design, including two conditions loss, i.e., 4 h first...
Abstract Obstructive sleep apnea syndrome (OSAS) and obesity go hand in the majority of patients both are associated with a systemic inflammation, immune disturbance comorbidities such as cardiovascular disease. However, unambiguous impact OSAS on individual inflammatory microenvironment immunological consequences human monocytes has not been distinguished yet. Therefore, aim this study was to investigate related factors by performing flow cytometric whole blood measurements CD14/CD16...
Abstract Objectives Recent studies have suggested a link between type 1 diabetes mellitus (T1D) and metabolic dysfunction associated steatotic liver disease (MASLD) in children adolescent, but longitudinal evidence is lacking. This study aimed to investigate the potential association poorly controlled T1D elevated alanine aminotransferase (ALT), serving as proxy for MASLD adolescents over time. Methods The included 32,325 aged 2−17 years with from Germany, Austria, Switzerland who had...
Complications of diabetes are often attributed to glucose and reactive dicarbonyl metabolites derived from glycolysis or gluconeogenesis, such as methylglyoxal. However, in the CNS, neurons endothelial cells use lactate energy source addition glucose, which does not lead formation methylglyoxal has previously been considered a safer route consumption than glycolysis. Nevertheless, hotspots for cellular pathology underlying neurological complications diabetes, suggesting cause that is...
The 'time-of-day' modifies the metabolic response to meals, but less data exist on diurnal variations in hedonic drive eat. In present paper, we evaluate effects of meal timing and macronutrient composition responses homeostatic vs. regulation appetite. study 1, 84 young, healthy adults completed an online computer-based task assessing eat morning evening. 2, 24 healthy, young men received 2 identical (850 kcal each) meals (8:45 h) evening (18:00 h), experimental conditions: (i) regular...
Abstract The aim of this study was to evaluate the newly developed non‐invasive blood glucose system NIRLUS® (Near‐Infra Red Light Ultra Sound; NIRLUS Engineering AG, Lübeck, Germany) under standardized conditions. Seventeen healthy men normal weight (body mass index 22.4 ± 1.4 kg/m 2 ), aged 18 45 years, were enrolled in study. During an intravenous tolerance test, profiles measured simultaneously using and a “gold standard” laboratory reference system. Correlation analysis revealed strong...
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We aimed to characterise and compare individuals diagnosed with type 1 diabetes (T1D), latent autoimmune in adults (LADA) 2 (T2D), a real-world setting.
Abstract During the COVID-19 pandemic, there were increased concerns about glycemic control in patients with diabetes. Therefore, we aimed to assess changes diabetes management during lockdown for type 1 or 2 mellitus (T1DM, T2DM) Germany. We included data from 24,623 (age>18 years) T1DM (N=6,975) T2DM (N=17,648) documented 2019 and 2020 multicenter Diabetes-Prospective Follow-up registry (DPV). conducted a groupwise comparison of identical different time periods pandemia. Pairwise...
Background: Continuous glucose monitoring (CGM) might have beneficial effects on glycemic control and body mass index (BMI) in adults with type 1 (T1D) or 2 diabetes (T2D). Methods: The prospective follow-up registry was used to identify individuals T1D T2D ≥18 years starting CGM management 2015 later information available. Hemoglobin A1c (HbA1c), BMI, event rates of severe hypoglycemia the year before start were compared two periods: (1) use for 3-6 months (2) >6 months. Repeated...
Abstract Obesity is characterized by excessive body fat accumulation and comorbidities such as diabetes mellitus, cardiovascular disease, obstructive sleep apnea syndrome (OSAS). Both obesity OSAS are associated with immune disturbance, alterations of systemic inflammatory mediators, cell recruitment to metabolic tissues. Chemokine CXCL10 an important regulator proinflammatory responses significantly increased in patients severe obesity. This research project aims investigate the impact on...
Abstract Obesity is a dramatically increasing disease, accompanied with comorbidities such as cardiovascular disease and obstructive sleep apnea syndrome (OSAS). Both obesity OSAS per se are associated systemic inflammation. However, the multifactorial impact of obesity, OSAS, its concomitant diseases on immunological characteristics circulating monocytes has not yet been fully resolved. Monocyte subsets 82 patients were analyzed in whole blood measurements terms CD14/CD16 cell surface...
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