A5022448511- Diabetes Management and Research
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Pharmacology and Obesity Treatment
- Liver Disease and Transplantation
- Advanced Causal Inference Techniques
- Clinical practice guidelines implementation
- Diet and metabolism studies
- Artificial Intelligence in Healthcare
- Diabetes and associated disorders
- Machine Learning in Healthcare
- Statistical Methods in Clinical Trials
- Pancreatitis Pathology and Treatment
- Metabolomics and Mass Spectrometry Studies
- Diabetes Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
Deutsches Diabetes-Zentrum e.V.
2023-2025
Heinrich Heine University Düsseldorf
2023-2025
German Center for Diabetes Research
2023-2025
Universitätsmedizin Göttingen
2024
Background Water T 1 of the liver has been shown to be promising in discriminating progressive forms fatty diseases, inflammation, and fibrosis, yet proper correction for iron lipid is required. Purpose To examine feasibility an empirical approach when measuring imaging‐based validate this by spectroscopy on vivo data. Study Type Retrospective. Population Next mixed lipid‐iron phantoms, individuals with different hepatic content were investigated, including people type diabetes ( N = 15,...
Fragestellung: Die Nationale Versorgungsleitlinie zum Typ-2-Diabetes (T2D) empfiehlt bei manifesten kardiovaskulären Erkrankungen oder einem hohen Risiko eine Therapie mit Metformin plus SGLT2-Inhibitoren (SGLT2i) GLP-1-Rezeptor-Agonisten (GLP-1-RA). Mit dem Ziel, datenbasiert personalisierte Behandlungsentscheidungen treffen zu können, untersuchten wir folgende Inwiefern können routinemäßig erfasste klinische Daten von Menschen T2D für Behandlungsentscheidung zwischen SGLT2i GLP-1-RA...
This work focuses on an empirical approach to determine water T1 from multiparametric MR images, including T1, PDFF and T2* maps. To this end, a multiple linear regression model was fit describe the deviation in MOLLI based values, which were measured phantoms built at increasing lipids iron content. method validated cohort of healthy volunteers diabetes subjects (n=45). Further investigations conducted elucidate relationship between before after correction for hepatic lipid content, liver...
In event-driven trials, the target power under a certain treatment effect is maintained as long required number of events obtained. The misspecification survival function in planning phase does not result loss power. However, trial might take longer than planned if event rate lower assumed. Blinded sample size reestimation (BSSR) uses non-comparative interim data to adjust some assumptions are wrong. setting an trial, may be adjusted maintain chances obtain within time frame. For purpose...
Typ-2-Diabetes (T2D) ist eine heterogene Erkrankung mit variierendem Krankheitsverlauf und Risiko für Komplikationen. Die metabolische Heterogenität des T2D kann nach Anwendung eines neuartigen Dimensionalitätsreduktionsverfahrens auf einer zweidimensionalen Baumstruktur visualisiert werden, sodass jede Person basierend 9 allgemein-verfügbaren klinischen Variablen an spezifischen Position dieser dargestellt wird. Ziel der Studie war, dieses Verfahren zu validieren untersuchen, ob diese...