A5025748703- Sphingolipid Metabolism and Signaling
- Cardiac Ischemia and Reperfusion
- Erythrocyte Function and Pathophysiology
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Cardiac electrophysiology and arrhythmias
- Advanced Nanomaterials in Catalysis
- Laser Applications in Dentistry and Medicine
- Cancer-related molecular mechanisms research
- Cardiac Fibrosis and Remodeling
- Cardiomyopathy and Myosin Studies
- Lipid Membrane Structure and Behavior
- Nanocluster Synthesis and Applications
- Neonatal Health and Biochemistry
- Cardiovascular Function and Risk Factors
- Tissue Engineering and Regenerative Medicine
- Angiogenesis and VEGF in Cancer
- Congenital heart defects research
- Salivary Gland Disorders and Functions
- Apelin-related biomedical research
- Mesenchymal stem cell research
- Bee Products Chemical Analysis
- Wnt/β-catenin signaling in development and cancer
Heinrich Heine University Düsseldorf
2022-2023
Düsseldorf University Hospital
2023
Ruhr University Bochum
2019-2020
Tabriz University of Medical Sciences
2012-2019
The current study aimed to address the impact of serum from type 2 diabetes patients on angiogenic properties human bone marrow mesenchymal stem cells and its relationship autophagy signaling. Human primary were enriched incubated with diabetic normal subjects for 7 days. Compared data control group, was found induce a higher cellular death rate (P < 0.001) apoptotic changes 0.01). We also showed that condition significantly abolished angiogenesis tube formation Matrigel substrate, decreased...
Key points The Anrep effect represents the alteration of left ventricular (LV) contractility to acutely enhanced afterload in a few seconds, thereby preserving stroke volume (SV) at constant preload. As result missing preload stretch our model, differs from slow force response and has different mechanism. demonstrated two phases. First, sudden increased was momentary equilibrated by LV as higher power strokes strongly‐bound myosin cross‐bridges. Second, slightly delayed recovery SV is...
Abstract Background 10 - Hydroxy-2-decenoic acid, an unsaturated fatty acid is the most active and unique component to royal jelly that has antimicrobial properties. Streptococcus mutans associated with pathogenesis of oral cavity, gingivoperiodontal diseases bacteremia following dental manipulations. In S. colonize soft tissues including tongue, palate, buccal mucosa. When considering role supragingival plaque in caries, proportion producing bacteria (particularly ), direct relevance...
Red blood cells (RBC) are the major carriers of sphingosine-1-phosphate (S1P) in blood. Here we show that variations RBC S1P content achieved by altering synthesis and transport genetic pharmacological means regulate glucose uptake metabolic flux. This is due to S1P-mediated activation catalytic protein phosphatase 2 (PP2A) subunit leading reduction cell-surface transporters (GLUTs). The mechanism dynamically responds cues from environment increasing synthesis, enhancing PP2A activity,...
In this study, the ability of methotrexate (MTX)-loaded stimuli-responsive novel silica nanocomposites (MSNs) (with mean diameter ± 60 nm) in induction apoptosis, and change Bax/Bcl-2 mRNA levels, were investigated. MTT assay RT -PCR analysis performed on MDA-MB-231 breast cancer cells, to evaluate their anti-proliferative, apoptotic anti-apoptotic effects. MTX-loaded MSNs caused marked decrease percentage viable with a significant down-regulation level expression gene (Bcl-2), up-regulation...
Ischemia/reperfusion injury is a tissue occurring post-reperfusion of tissues with pre-existing ischemia. A good blood supply to aids in the survival ischemic tissue, however, due prolonged ischemia levels ATP decrease and pH declines leading acidosis. Reduced leads an increase AMP/ATP ratio, causing cessation intracellular calcium transport, hence overload cell death. In this study, we demonstrate synergistic antagonistic effect DJ1 microR-214 (miR-214) rescuing myoblast C2C12 cells after...
Purpose: Cardiovascular gene therapy is a sophisticated approach, thanks to the safety of vectors, stable transgene expression, delivery method, and different layers heart. To date, numerous expression vectors have been introduced in biotechnology biopharmacy industries relation genetic manipulation. Despite rapid growth these modalities, they must be intelligently designed, addressing cardiac-specific less side effects. Herein, we conducted pilot project aiming design hypoxia-inducible...
Abstract Membrane phospholipids affect GLUT function in RBC but the role of their large intercellular S1P pool is unknown. We show that altering content by intervening its precursor uptake, synthesis and efflux had major impacts on glucose uptake glycolysis. identified mechanism as direct activation PP2A leading to cell-surface reduction. This was highly dynamic it responded metabolic cues from environment regulating intracellular thereby hence counteracting pathophysiological conditions...