A5032042281- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Fibroblast Growth Factor Research
- Diet, Metabolism, and Disease
- Estrogen and related hormone effects
- Fatty Acid Research and Health
- Xenotransplantation and immune response
- Cholesterol and Lipid Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Pharmacological Effects of Natural Compounds
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and biosynthesis
- Hormonal and reproductive studies
- Genetic Syndromes and Imprinting
University of Lübeck
2021-2024
German Center for Diabetes Research
2023-2024
Institute of Molecular and Cell Biology
2023
Technical University of Munich
2023
Universidade Estadual de Campinas (UNICAMP)
2023
Yale University
2023
University of Salzburg
2023
University of Augsburg
2023
Universität Hamburg
2023
University Medical Center Hamburg-Eppendorf
2023
Background: The development of obesity-associated comorbidities such as type 2 diabetes (T2D) and hepatic steatosis has been linked to selected microRNAs in individual studies; however, an unbiased genome-wide approach map T2D induced changes the miRNAs landscape human liver samples, a subsequent robust identification validation target genes are still missing. Methods: Liver biopsies from age- gender-matched obese individuals with (n=20) or without were used for microRNA microarray analysis....
DNA methylation is dynamically regulated in metabolic diseases, but it remains unclear whether the changes are causal or consequential. Therefore, we used a longitudinal approach to refine onset of and at high temporal resolution. Male C57BL/6N mice were fed with 60 % high-fat diet (HFD) for up 12 weeks metabolically characterized weekly. Liver was collected after 1, 2, 4, 5, 6, 7, 8, hepatic gene expression analyzed. A subset obese underwent vertical sleeve gastrectomy (VSG) metformin...
De novo lipogenesis (DNL) in visceral adipose tissue (VAT) is associated with systemic insulin sensitivity. DNL VAT regulated through ChREBP activity and glucose uptake Glut4 (encoded by Slc2a4). Slc2a4 expression, activity, are decreased obesity, the underlying cause however remains unidentified. We hypothesize that increased DNA methylation an enhancer region of decreases expression obesity resistance. found SLC2A4 morbidly obese subjects high HbA1c (>6.5%, n = 35) decreased, whereas...
Background: The development of obesity-associated comorbidities such as type 2 diabetes (T2D) and hepatic steatosis has been linked to selected microRNAs in individual studies; however, an unbiased genome-wide approach map T2D induced changes the miRNAs landscape human liver samples, a subsequent robust identification validation target genes are still missing. Methods: Liver biopsies from age- gender-matched obese individuals with (n=20) or without were used for microRNA microarray analysis....
Objective Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by inflammation, fibrosis, and accumulation of fatty acids in the liver. MASH disease progression has been associated with reduced thyroid hormone (TH) signaling liver, including expression deiodinase type I (DIO1) TH receptor beta (THRB). However, underlying mechanisms mediating these effects remain elusive. Here, we hypothesized that epigenetic may be involved modulating hepatic action. Methods Liver samples...
The development of obesity-associated comorbidities such as type 2 diabetes (T2D) and hepatic steatosis has been linked to selected microRNAs in individual studies; however, an unbiased genome-wide approach map T2D induced changes the miRNAs landscape human liver samples, a subsequent robust identification validation target genes is still missing.Liver biopsies from age- gender-matched obese individuals with (n=20) or without were used for microRNA microarray analysis. candidate validated 85...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Nesfatin-1, the cleavage product of nucleobindin-2, is an anorexigenic peptide and major regulator energy homeostasis. Beyond reducing food intake increasing expenditure, it also involved in regulating stress response. Interaction nucleobindin-2/nesfatin-1 glucose homeostasis has been observed recent findings suggest a link between action antidiabetic drug metformin nesfatinergic system. Hence, this study aimed to clarify role paraventricular nucleus hypothalamus as well its...
Abstract Background The development of obesity-associated comorbidities such as type 2 diabetes (T2D) and hepatic steatosis has been linked to selected microRNAs in individual studies; however, an unbiased genome-wide approach map T2D induced changes the miRNAs landscape human liver samples, a subsequent robust identification validation target genes is still missing. Methods Liver biopsies from age- gender-matched obese individuals with (n=20) or without were used for microRNA microarray...
The development of obesity-associated comorbidities such as type 2 diabetes (T2D) and hepatic steatosis has been linked to selected microRNAs in individual studies; however, an unbiased genome-wide approach map T2D induced changes the miRNAs landscape human liver samples, a subsequent robust identification validation target genes is still missing.Liver biopsies from age- gender-matched obese individuals with (n=20) or without were used for microRNA microarray analysis. candidate validated 85...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Hypothesis The development of leptin-reducing strategies demands the precise understanding surprisingly poorly studied regulation leptin gene expression in response to nutritional status. To address this regulation, we investigated if DNA methylation distinct enhancer elements leptin, as epigenetic answer factors, influences and is dynamic.
Hypothesis This work aimed to clarify whether nesfatin-1, a peptide of the paraventricular nucleus (PVN) involved in central nervous energy balance regulation, is mediator for effects metformin on homeostasis. Focussing particular food intake and expenditure induction weight loss by was studied.
Objective Fibroblast growth factor 21 (FGF21) improves weight loss, glucose metabolism and insulin signaling. FGF21 is mainly expressed in the liver, but acts adipose tissue. Obesity associated with changes DNA methylation, which alters gene expression. Therefore, we aim to study epigenetic regulation of Fgf21 if it impaired signaling observed human murine