A5038607643- Civil and Structural Engineering Research
- Structural Analysis of Composite Materials
- Spinal Fractures and Fixation Techniques
- Lower Extremity Biomechanics and Pathologies
- Bone fractures and treatments
- Radiomics and Machine Learning in Medical Imaging
- Spine and Intervertebral Disc Pathology
- Soft Robotics and Applications
- Artificial Intelligence in Healthcare and Education
- Surgical Simulation and Training
- Scoliosis diagnosis and treatment
- Diabetic Foot Ulcer Assessment and Management
- Building materials and conservation
- Foot and Ankle Surgery
- Anatomy and Medical Technology
- Shoulder Injury and Treatment
- Radiology practices and education
- Tendon Structure and Treatment
- Adipose Tissue and Metabolism
- Orthopedic Surgery and Rehabilitation
- Hip disorders and treatments
- Environmental Impact and Sustainability
- Orthopaedic implants and arthroplasty
- Regulation of Appetite and Obesity
- Hip and Femur Fractures
University Medical Center of the Johannes Gutenberg University Mainz
2022-2024
Johannes Gutenberg University Mainz
2022-2024
University Medical Centre Mannheim
2024
National Medical Research Center of Dentistry and Maxillofacial Surgery
2024
TU Wien
2019-2023
University of Lübeck
2022
Berufsgenossenschaftliche Unfallklinik Murnau
2012-2018
W&H (Austria)
2016-2018
Leipzig University
2014
Paracelsus Medical University
2012-2014
Objectives: Intramedullary nails with special lag screw designs may provide improved mechanical performance and alleviate clinical problems. We hypothesize that the proximal design of trochanteric affects performance. Methods: Ten pairs human cadaveric femora were implanted 2 different short intramedullary without (Gamma3) an interlocking (Intertan). An unstable, multifragmentary, pertrochanteric fracture was created. Bones tested in a cyclic testing protocol increasing loads until failure...
Background: Metatarsocuneiform (MTC) fusion is a treatment option for management of hallux valgus. We compared the biomechanical characteristics an internal fixation device with plantar plate fixation. Methods: Seven matched pairs feet from human cadavers were used to compare intramedullary (IM) plus compression screw combined screw. Specimen constructs loaded in cyclic 4-point bending test. obtained initial/final stiffness, maximum load, and number cycles failure. Bone mineral density was...
Chronic and acute tendinopathies are difficult to treat tendon healing is generally a very slow incomplete process our general understanding of biology regeneration lags behind that muscle or bone. Although still largely unexplored, several studies suggest positive effect nutritional interventions on health repair. With this study, we aim reveal effects high-glucose diet neoformation in non-diabetic rat model Achilles tenotomy. After surgery animals received either control for 2 4 weeks,...
Background Structured and standardized documentation is critical for accurately recording diagnostic findings, treatment plans, patient progress in health care. Manual can be labor-intensive error-prone, especially under time constraints, prompting interest the potential of artificial intelligence (AI) to automate optimize these processes, particularly medical documentation. Objective This study aimed assess effectiveness ChatGPT (OpenAI) generating radiology reports from dental panoramic...
<sec> <title>UNSTRUCTURED</title> Objectives: Artificial intelligence (AI) has emerged as a transformative tool in healthcare, particularly improving medical documentation and communication. This study investigates the potential of ChatGPT, an AI language model, to enhance patient comprehension radiology reports through simplification. Materials Methods: Three versions were evaluated: original AI-generated, simplified, further simplified versions. Patient feedback 300 patients was collected...
Background: Toxicity of the local anesthetic bupivacaine (BV) has been a matter debate across medical fields. Numerous in vitro studies demonstrate considerable toxicity BV on various cell types. Purpose: This study addresses question how tendon tissue responds to vivo and vitro. Study Design: Controlled laboratory study. Methods: In cultured rat Achilles tendon–derived cells were performed with viability assays cleaved caspase 3 immunocytochemistry. Quantitative reverse...
Currently the surgical training of kyphoplasty and vertebroplasty is performed on patients or specimens. To improve patient safety, a project was initiated to develop an Augmented Reality simulator for these interventions. Artificial vertebral segments should be integrated provide realistic haptic feedback. reach this, resulting forces during needle insertions (trans- extrapedicular) into formalin-fixed specimens were measured. The same insertion procedure also six customized polyurethane...
Abstract To extend the indications of intramedullary nails for distal or proximal fractures, with angle stable locking options have been developed. Studies on mechanical efficacy these systems inconsistent likely due to confounding variables such as number, geometry, orientation screws, well differences in loading mode. Therefore, aim this study was quantify effect angular stability performance nails. The results could then be compared effects various screw parameters and modes. A generic...
Free flap tissue transfer represents the gold standard for extensive defect reconstruction, although malperfusion due to thrombosis remains leading risk factor failure. Recent studies indicate an increased immune response and platelet activation in connection with pathologic coagulation. The underlying cellular molecular mechanisms remain poorly understood, however. presented study, therefore, aims investigate if transfer-related ischemia alters intra-flap metabolism electrolyte...
Study Design. Biomechanical Laboratory Study. Objective. Analysis of the biomechanical characteristics a novel sacral constrained dual-screw fixation device (S1-PALA), combining S1-pedicle screw and S1-ala screw, compared to standard bicortical (S1-PS) fixation. Summary Background Data. Instrumented fusions sacrum are biomechanically challenging plagued by high risk nonunion when S1-PS is used as sole means Thus, lumbopelvic increasingly selected instead, although associated with reasonable...
Treatment of distal tibia shaft fractures using intramedullary nailing requires stable fixation the fragment to prevent malunion. Angular locking for nails pledge provide increased mechanical stability. This study tested hypothesis that with angular interlocking screws would have construct stiffness, reduced fracture gap movement and enhanced fatigue failure compared conventional having same diameter. Biomechanical experiments were performed on 24 human cadaveric tibiae which obtained a...
Diabetes mellitus is a risk factor for various types of tendon disorders. The mechanisms underlying diabetes associated tendinopathies remain unclear, but typically, systemic factors related to high blood glucose levels are thought be causally involved. We hypothesize that immanent cells might directly involved in diabetic tendinopathy. therefore analyzed human and rat tendons by immunohistochemistry, laser capture microdissection, single cell PCR pancreatic β-cell markers. Moreover, we...
Patients with calcaneus fractures experience considerable interferences daily living activities. The quality of anatomical reconstruction is important because its influence on functional outcome. aim this study was to develop an automatic algorithm based computer tomographic (CT) images quantify the integrity calcaneal joint surfaces. Validation done by assessing intra-individual variations characteristic parameters. Bilateral hind foot CT data 12 subjects were manually segmented, and 3D...
Free flap failure represents a substantial clinical burden. The role of intraoperative volume management remains controversial, with valid studies lacking. Here, using large animal model, we investigated the influence on free perfusion and metabolism. Autotransfer musculocutaneous gracilis was performed 31 German domestic pigs, arterial anastomosis catheterization pedicle vein for sequential blood sampling. Flap reperfusion followed by induction hemorrhagic shock maintenance 30 min...
Abstract Currently the surgical training of parietal bone graft techniques is performed on patients or specimens. Commercially available models do not deliver realistic haptic feedback. Thus customized skull surrogates were developed for purposes. Two human bones used as reference. Based measurement insertion forces drilling, milling and saw procedures suitable material compositions molding cortical cancellous calvarial layers found. Artificial caps manufactured tested. Additionally...
Cranial grafts are favored to reconstruct skeletal defects because of their reduced resorption and histocompatibility. Training possibilities for novice surgeons include the "learning by doing" on patient, specimens or simulators. Although acceptance simulators is growing, major drawback lack validated bone models. The aim this study was create validate a realistic skull cap model show superiority compared commercially available model. Characteristic forces during machinery procedures were...
In Brief Study Design. A biomechanical calf cadaver study. Objective. The purpose of this study was to determine the intradiscal pressure gradient bridged healthy intervertebral segments in correlation with intraoperative distraction force. Summary Background Data. Bisegmental dorsal stabilization and anatomic reduction is a common treatment option for incomplete burst fractures lumbar spine. However, it remains unknown what extent bridging compromises an intact disc. Methods. L2–L3 disc...
Biomechanical in vitro laboratory study.To compare the biomechanical performance of 3 fixation concepts used for anterior instrumented scoliosis correction and fusion (AISF).AISF is an ideal estimate selective adolescent idiopathic scoliosis. Correction mediated using rods screws anchored vertebral bodies. Application large forces can promote early weakening implant-vertebra interfaces, with potential postoperative loss correction, implant dislodgment, nonunion. Therefore, improvement...