A5028401584- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- S100 Proteins and Annexins
- Tryptophan and brain disorders
- Liver Disease Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Health disparities and outcomes
- Chronic Kidney Disease and Diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Ginkgo biloba and Cashew Applications
- Metabolomics and Mass Spectrometry Studies
- Nuclear Receptors and Signaling
- Adipose Tissue and Metabolism
- Dialysis and Renal Disease Management
- Immune responses and vaccinations
- Neurological diseases and metabolism
- Health Systems, Economic Evaluations, Quality of Life
- Inflammatory mediators and NSAID effects
- Fibroblast Growth Factor Research
- Aging and Gerontology Research
- Vitamin K Research Studies
- GDF15 and Related Biomarkers
German Cancer Research Center
2020-2025
Heidelberg University
2020-2025
University Hospital Heidelberg
2020-2023
Heidelberg University
2022
Importance Previous research has suggested an association of kidney function with risk Alzheimer disease (AD) or other dementias and dementia-related blood biomarkers, but a distinct remains unclear. Objective To evaluate the diagnosis incident AD dementia within 17 years biomarkers neurofilament light (NfL), phosphorylated tau181 (p-tau181), glial fibrillary acidic protein (GFAP). Design, Setting, Participants In this prospective, population-based cohort study nested case-control study,...
Abstract Background In order to utilize polygenic risk scores (PRSs) for Alzheimer’s disease (AD) in a meaningful way, influential factors (i.e. training set) and prediction across groups such as APOE e4 (APOE4) genotype well associations dementia-related biomarkers should be explored. Therefore, we examined the association of APOE4 various PRSs, based on sets that utilized differing AD definitions, with incident all-cause dementia (ACD) within 17 years, levels phosphorylated tau181...
Abstract Background Chronic inflammation is a central feature of several forms dementia. However, few details on the associations blood-based inflammation-related proteins with dementia incidence have been explored yet. Methods The Olink Target 96 Inflammation panel was measured in baseline serum samples (collected 07/2000–06/2002) 1782 older adults from German, population-based cohort study case-cohort design. Logistic regression models were used to assess biomarkers all-cause dementia,...
Background Using data from the largest German cohort study, we aimed to investigate sex differences in relationship of socioeconomic position (SEP) with cardiovascular disease (CVD), CVD risk factors, and estimated risk. Methods Results A total 204 780 (50.5% women) participants baseline examination population‐based NAKO (German National Cohort) were included. Logistic, multinomial, linear regression models used estimate sex‐specific odds ratios (ORs) β coefficients 95% CIs CVD, very...
Understanding determinants of thoracic aortic morphology is crucial for precise diagnostics and therapeutic approaches. This study aimed to automatically characterize ascending based on 3D non-contrast-enhanced magnetic resonance angiography (NC-MRA) data from the epidemiological cross-sectional German National Cohort (NAKO) investigate possible mid-ascending diameter (mid-AAoD). Deep learning (DL) segmented aorta length, volume, was extracted 25,073 NC-MRAs. Statistical analyses...
Abstract Introduction Prospective studies on a potential association of 8‐iso‐prostaglandin F 2α (8‐iso‐PGF ) levels, biomarker lipid peroxidation, with dementia are limited. Methods Multivariate Cox regression models were used to assess associations urinary 8‐iso‐PGF levels all‐cause, Alzheimer's disease (AD), and vascular (VD) incidence in 5853 older adults from German, population‐based cohort. Results Over 14 years follow‐up, 365 all‐cause cases including 127 VD 109 AD diagnosed....
Abstract Background Subjective cognitive complaints (SCC) have been mostly studied in the context of Alzheimer’s disease memory clinic settings. The potential combining SCC with genetic information and blood biomarkers neurodegenerative diseases for risk assessment dementia depression absence among community-dwelling older adults has so far not explored. Methods Data were based on a population-based cohort 6357 participants 17-year follow-up (ESTHER study) clinic-based 422 patients....
Abstract Background It is of interest whether inflammatory biomarkers can improve dementia prediction models, such as the widely used Cardiovascular Risk Factors, Aging and Dementia (CAIDE) model. Methods The Olink Target 96 Inflammation panel was assessed in a nested case-cohort design within large, population-based German cohort study ( n = 9940; age-range: 50–75 years). All participants who developed over 20 years follow-up had complete CAIDE variable data 562, including 173 Alzheimer’s...
Abstract Introduction This study assessed whether in a population with comorbidity of neurodegenerative and cerebrovascular disease (mixed pathology) the association glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), phosphorylated tau181 (p‐tau181) dementia risk varied depending on levels total cholesterol apolipoprotein E ( APOE ) ε4 genotype. Methods Plasma biomarkers were measured using Simoa technology 768 participants nested case‐control embedded within an ongoing...
Subjective hearing and memory problems are detectable earlier than objective measures of sensory loss cognitive decline, which known to be related an increased risk dementia in later life.
Abstract Background and Aims To evaluate the potential of improved prediction 10-year risk major adverse cardiovascular events (MACE) in patients with type 2 diabetes by adding metabolomic biomarkers to SCORE2-Diabetes model. Methods Data from 10,257 1,039 UK Biobank (UKB) German ESTHER cohort, respectively, were used for model derivation, internal external validation. A total 249 metabolites measured nuclear magnetic resonance (NMR) spectroscopy. LASSO regression bootstrapping was identify...
ABSTRACT Background Pathologies of the thoracic aorta are associated with chronic cardiovascular disease and can be life-threatening nature. Understanding determinants aortic morphology is crucial for precise diagnostics preventive therapeutic approaches. This study aimed to automatically characterize ascending based on 3D non-contrast-enhanced magnetic resonance angiography (NE-MRA) data from large epidemiological cross-sectional German National Cohort (NAKO) investigate possible...
Polygenic risk scores (PRS) and subjective cognitive decline (SCD) are associated with the of developing dementia. It remains to examine whether they can improve established cardiovascular factors aging dementia (CAIDE) model how their predictive abilities compare.
Abstract Importance Chronic inflammation is increasingly recognized as a central feature of several forms dementia. Objective To determine which biomarkers the inflammation-related proteome are associated with all-cause dementia, Alzheimer’s disease (AD), or vascular dementia (VD). Design Analyses were performed in case-cohort study design based on an ongoing German population-based cohort study. Setting Serum samples participants collected at baseline (2000-20002), and followed up for 17...
Abstract Objectives To investigate the association between long term low-dose acetylsalicylic acid (LDASA) use and development of all-cause dementia, Alzheimer’s disease (AD) vascular dementia (VD). Design Meta-analysis individual participant data from two prospective cohort studies. Setting Community-dwelling older adults Germany (ESTHER) United Kingdom (UK Biobank). Participants 5,258 ESTHER 305,394 UK Biobank participants who were 55 years or completed drug assessment included for...