A5100685367- Neuroscience and Neuropharmacology Research
- Ion Channels and Receptors
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Pharmacological Receptor Mechanisms and Effects
- Functional Brain Connectivity Studies
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Stress Responses and Cortisol
- Nicotinic Acetylcholine Receptors Study
- Neurogenesis and neuroplasticity mechanisms
- Liver Disease Diagnosis and Treatment
- Tryptophan and brain disorders
- Gut microbiota and health
- EEG and Brain-Computer Interfaces
- Metabolomics and Mass Spectrometry Studies
- Cancer-related cognitive impairment studies
- Neural dynamics and brain function
- Nuclear Structure and Function
- Neuroendocrine regulation and behavior
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- RNA modifications and cancer
- Mitochondrial Function and Pathology
Capital Medical University
2022-2025
Beijing Anding Hospital
2022-2025
Heidelberg University
2024-2025
German Cancer Research Center
2024-2025
Nanjing Medical University
2015-2024
Sorbonne Université
2022
Centre de Recherche Saint-Antoine
2022
Hôpital Saint-Antoine
2022
Xuzhou Medical College
2022
Yale University
2020
Abstract Activation of transient receptor potential vanilloid 4 (TRPV4) induces neuronal injury. TRPV4 activation enhances inflammatory response and promotes the proinflammatory cytokine release in various types tissue cells. Hyperneuroinflammation contributes to damage epilepsy. Herein, we examined contribution neuroinflammation TRPV4-induced neurotoxicity its involvement inflammation pilocarpine model temporal lobe epilepsy mice. Icv. injection agonist GSK1016790A (GSK1016790A-injected...
Background Major Depressive Disorder (MDD) is a pervasive mental health issue with significant diagnostic challenges. Electroencephalography (EEG) offers non-invasive window into the neural dynamics associated MDD, yet efficacy contingent upon appropriate selection of EEG features and brain regions. Methods In this study, resting-state signals from both eyes-closed eyes-open conditions were analyzed. We examined band power across various regions, assessed asymmetry between hemispheres,...
The incidence of type 1 diabetes (T1D) has been increasing among children and adolescents, in which environmental factors, including gut microbiota, play an important role. However, the underlying mechanisms are yet to be determined. Here, we show that patients with newly diagnosed T1D displayed not only a distinct profile microbiota associated decreased short-chain fatty acids (SCFAs) production, but also altered IgA-mediated immunity compared healthy control subjects. Using germ-free NOD...
This study investigated the influence of sigma-1 receptor (σ1 R) deficiency on adult neurogenesis.We employed 8-week-old male σ1 R knockout R(-/-) ) mice to examine proliferation and differentiation progenitor cells, survival neurite growth newborn neurons in hippocampal dentate gyrus (DG).In comparison with wild-type (WT) littermates, numbers 24-h-old BrdU(+) cells Ki67(+) increased, while number 28-day-old decreased without changes proportion /NeuN(+) /GFAP(+) cells. The density was...
A characteristic phenotype of congenital generalized lipodystrophy 2 (CGL2) that is caused by loss-of-function seipin gene mental retardation. Here, we show deficiency in hippocampal CA1 pyramidal cells the reduction peroxisome proliferator-activated receptor gamma (PPARγ). Twelve-week-old systemic knock-out mice and neuronal ( -nKO) mice, but not adipose exhibited spatial cognitive deficits as assessed Morris water maze Y-maze, which were ameliorated treatment with PPARγ agonist...
The mechanisms by which neonatal inflammation leads to cognitive deficits in adulthood remain poorly understood. Inhibitory GABAergic synaptic transmission plays a vital role controlling learning, memory and plasticity. Since early-life has been reported adversely affect the transmission, aim of this study was investigate whether how affects resulting impairment. Neonatal mice received daily subcutaneous injection lipopolysaccharide (LPS, 50 μg/kg) or saline on postnatal days 3-5. It found...
Williams-Beuren syndrome (WBS) is a microdeletion disorder with cognitive phenotype. NSUN5 gene, which encodes cytosine-5 RNA methyltransferase, located in WBS deletion locus. To investigate the influence of on behaviors, we produced single-gene Nsun5 knockout (Nsun5-KO) mice. Here, report that adult Nsun5-KO mice showed spatial deficits. Size brain and hippocampal structures number CA1 or CA3 pyramidal cells did not differ from WT Basal properties Schaffer collateral-CA1 synaptic...
In this study, we used GM2/GD2 synthase knockout (GM2/GD2−/−) mice to examine the influence of deficiency in ganglioside “a-pathway” and “b-pathway” on cognitive performances hippocampal synaptic plasticity. Eight-week-old GM2/GD2−/− male showed a longer escape-latency Morris water maze test shorter latency step-down inhibitory avoidance task than wild-type (WT) mice. Schaffer collateral-CA1 synapses slices from an increase slope EPSPs with reduced paired-pulse facilitation, indicating...
Background: Continuous administration of low-dose nonsteroidal anti-inflammatory drugs such as indomethacin (IND) is associated with an increased risk gastrointestinal damage. In this study, the authors developed IND-loaded redox nanoparticles (IND@RNPO) core–shell-type polymeric micelles possessing nitroxide radicals reactive oxygen species scavengers. Results: Orally administered IND@RNPO significantly accumulated in intestinal mucosa and improved blood uptake IND. Because...
A novel Gram-stain-negative, flagellated, rod-shaped, yellow-pigmented aerobic bacterium, strain SA925T, that is capable of degrading 1-methylphenanthrene was isolated from oil-polluted soil collected a refinery located in Guangzhou, China. Phylogenetic analysis based on the 16S rRNA gene sequence demonstrated SA925T belongs to genus Novosphingobium and evolutionarily close type strains gossypii (98.5 % similarity), panipatense (98.2 %), mathurense (98.0 %) pentaromativorans (96.5 %). The...
Seipin gene is originally identified as a loss-of-function for congenital generalized lipodystrophy type 2 (CGL2). Neuronal seipin knockout (seipin-nKO) mice display depression-like phenotype with reduction of hippocampal peroxisome proliferator-activated receptor gamma (PPARγ) level. The present study investigated the influence deficiency on adult neurogenesis in dentate gyrus (DG) and underlying mechanisms. Here, we show that proliferative capability stem cells seipin-nKO was significantly...
It has been suggested that there is a critical window for estrogen replacement therapy in postmenopausal women with Alzheimer's disease; however, supporting evidence lacking. To address this issue, we investigated the effective period estradiol (E2) treatment using mouse model of AD. Four-month-old female APPswe/PSEN1dE9 (APP/PS1) mice were ovariectomized (OVX) and treated E2 2 months starting at age 4 (early period), 6 (mid or 8 (late period). We then evaluated hippocampal neurogenesis,...