A5101874169- Ion Channels and Receptors
- Acupuncture Treatment Research Studies
- Neuroscience and Neuropharmacology Research
- Nitric Oxide and Endothelin Effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion channel regulation and function
- Neurological Disease Mechanisms and Treatments
- Myofascial pain diagnosis and treatment
- Anesthesia and Neurotoxicity Research
- Neurogenesis and neuroplasticity mechanisms
- Ginkgo biloba and Cashew Applications
- Biochemical effects in animals
- Physical Education and Training Studies
- Cardiac Arrest and Resuscitation
- Diet, Metabolism, and Disease
- Cholinesterase and Neurodegenerative Diseases
- Complementary and Alternative Medicine Studies
- Intracranial Aneurysms: Treatment and Complications
- Electron Spin Resonance Studies
- Respiratory Support and Mechanisms
- Ginseng Biological Effects and Applications
- MicroRNA in disease regulation
- Psychosomatic Disorders and Their Treatments
- Facial Nerve Paralysis Treatment and Research
- Intracerebral and Subarachnoid Hemorrhage Research
Dalian Medical University
2022
Chongqing Medical University
2022
Second Affiliated Hospital of Chongqing Medical University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Nanjing Medical University
2008-2021
West China Hospital of Sichuan University
2021
Sichuan University
2021
Second Affiliated Hospital of Nanjing Medical University
2018
Huaian First People’s Hospital
2018
Harbin Medical University
2018
Abstract Activation of transient receptor potential vanilloid 4 (TRPV4) induces neuronal injury. TRPV4 activation enhances inflammatory response and promotes the proinflammatory cytokine release in various types tissue cells. Hyperneuroinflammation contributes to damage epilepsy. Herein, we examined contribution neuroinflammation TRPV4-induced neurotoxicity its involvement inflammation pilocarpine model temporal lobe epilepsy mice. Icv. injection agonist GSK1016790A (GSK1016790A-injected...
Objective.— To discuss the results of a multicenter randomized controlled trial efficacy verum acupuncture in treating acute migraine attacks. Background.— Acupuncture has been used China for centuries to treat headache. Convincing evidence its alleviating pain, however, inadequate date. Methods.— A total 218 patients with were recruited study; 180 met inclusion criteria; 175 completed callback process and into 3 groups. One group received while subjects other 2 groups treated sham...
As a result of its spatial confinement in cardiomyocytes, neuronal nitric oxide synthase (nNOS) is thought to regulate mitochondrial and sarcoplasmic reticulum (SR) function by maintaining nitroso-redox balance Ca(2+) cycling. Thus, we hypothesize that ischemic postconditioning (IPostC) protects hearts against ischemic/reperfusion (I/R) injury through an nNOS-mediated pathway. Isolated mouse were subjected I/R Langendorff apparatus, H9C2 cells primary neonatal rat cardiomyocytes...
Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of damage characterized by abnormal hepatic fat accumulation and inflammatory response. Although the molecular mechanisms responsible for are not yet fully understood, pathogenesis NAFLD likely involves multiple signals. The identification effective therapeutic strategies to target these signals is utmost importance. Carnosic acid (CA), as phenolic diterpene with anticancer, anti-bacterial, anti-diabetic neuroprotective...
Abstract Activation of transient receptor potential vanilloid 4 (TRPV4) can increase hippocampal neuronal excitability. TRPV4 has been reported to be involved in the pathogenesis epilepsy. Voltage‐gated potassium channels (VGPCs) play an important role regulating excitability and abnormal VGPCs expression or function is related Here, we examined effect activation on delayed rectifier current ( I K ) pyramidal neurons Kv subunits male mice. We also explored changes mice following...
Glycine plays an important role in regulating hippocampal inhibitory/ excitatory neurotransmission through activating glycine receptors (GlyRs) and acting as a co-agonist of N-methyl-d-aspartate-type glutamate receptors. Activation transient receptor potential vanilloid 4 (TRPV4) is reported to inhibit A-type γ-aminobutyric acid receptor, ligand-gated chloride ion channel. GlyRs are also channels this paper aimed explore whether activation TRPV4 could modulate GlyRs.Whole-cell patch clamp...
Many patients develop severe and persistent pain after hepatectomy delaying postoperative rehabilitation. Studies have suggested that intravenous lidocaine infusion relieved improved overall outcomes. However, its efficacy on is still masked, due to the metabolic change of by liver. We hypothesized in perioperative period would lead reduction improve patient experience.In this prospective double-blind, randomized controlled design trial, 260 adults scheduled for will be allocated placebo...
Abstract Objective To investigate how the Epstein‐Barr virus (EBV) encoded microRNA BART7 (miR‐BART7) affects tumorigenicity, metastasis, and TRAIL sensitivity of non‐small cell lung cancer (NSCLC). Methods Real time‐polymerase chain reaction was performed to detect miR‐BART7 expression in NSCLC lines. A549 Calu‐1 cells transfected with inhibitors/mimics were used do in‐vitro experiments, including 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide, Annexin V‐fluorescein...
The rapidly inactivating potassium current (IA ) is important in controlling neuronal action potentials. Altered IA function and K+ channel expression have been found epilepsy, activation of the transient receptor potential vanilloid 4 (TRPV4) involved epilepsy pathogenesis. This study examined whether TRPV4 affects Kv4.2 interacting protein (KCHIP) changes following pilocarpine-induced status epilepticus (PISE) mice. Herein, hippocampal levels KCHIP2 increased 3 h-3 d decreased 7-30 d; that...
To further evaluate the safety of ginkgo diterpene lactone meglumine injection in clinical use ischemic stroke patients. Clinical study was conducted 82 units and 6 300 cases were completed included from June 2013 to December 2014 by using multicenter, prospective, open uncontrolled design methods for research. A total 29 adverse reactions observed experiment. Adverse reaction ratio (ADR) 0.46%, about 86.21% (25 cases) them mild with transient response which could be alleviated or...
Abstract Background: Nonspecific neck pain (NNP) is a common type of that causes serious health problems and closely related to myofascial syndrome (MPS). Here, we compare the effectiveness ultrasound-guided trigger point injection therapy (TPI) conventional physical treatment in patients with NNP multiple dimensions. Methods: Thirty-eight were randomly assigned control group TPI group, single dose 3 ml 0.5% lidocaine was injected into each points all affected muscles under ultrasound...
Objective To observe the therapeutic effects of oral placement therapy (OPT) on managing sialorrhea after stroke.Methods A total 37 stroke inpatients with were enrolled from January 2011 to September 2013 in authors' department for study and divided into 2 group basis time enrollment.The control (n =18) received 30min routine treatment (including such neuromuscular facilitation techniques as Bobath Rood techniques,motor relearning program,neuromuscular electrical stimulation ice...