A5051797489- Hormonal Regulation and Hypertension
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Renin-Angiotensin System Studies
- Apelin-related biomedical research
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Cryptographic Implementations and Security
- Physical Unclonable Functions (PUFs) and Hardware Security
- Nitric Oxide and Endothelin Effects
- MicroRNA in disease regulation
- Heat Transfer and Optimization
- Cardiovascular Disease and Adiposity
- Circular RNAs in diseases
- Eicosanoids and Hypertension Pharmacology
- Pulmonary Hypertension Research and Treatments
- Chaos-based Image/Signal Encryption
- Advanced Malware Detection Techniques
- Blood Pressure and Hypertension Studies
- Inflammasome and immune disorders
- Peptidase Inhibition and Analysis
- Cancer, Lipids, and Metabolism
- Ion Channels and Receptors
- Cardiac Valve Diseases and Treatments
- Regulation of Appetite and Obesity
- Cancer-related molecular mechanisms research
Nanjing Medical University
2009-2025
Beijing Union University
2018-2024
Target (United States)
2024
Kangda College of Nanjing Medical University
2023
State Key Laboratory of Virology
2023
University of Duisburg-Essen
2023
Second Affiliated Hospital of Nanjing Medical University
2019-2023
Wannan Medical College
2010-2023
Zhejiang Ocean University
2023
Children's Hospital of Fudan University
2023
Abstract Glucose metabolism and innate immunity evolved side-by-side. It is unclear if how the two systems interact with each other during hepatitis B virus (HBV) infections and, so, which mechanisms are involved. Here, we report that HBV activates glycolysis to impede retinoic acid-inducible gene I (RIG-I)-induced interferon production. We demonstrate sequesters MAVS from RIG-I by forming a ternary complex including hexokinase (HK). Using series of pharmacological genetic approaches,...
Abstract Activation of transient receptor potential vanilloid 4 (TRPV4) induces neuronal injury. TRPV4 activation enhances inflammatory response and promotes the proinflammatory cytokine release in various types tissue cells. Hyperneuroinflammation contributes to damage epilepsy. Herein, we examined contribution neuroinflammation TRPV4-induced neurotoxicity its involvement inflammation pilocarpine model temporal lobe epilepsy mice. Icv. injection agonist GSK1016790A (GSK1016790A-injected...
In this study, we demonstrated an essential function of the hexosamine biosynthesis pathway (HBP)-associated O-linked β-N-acetylglucosamine (O-GlcNAc) signaling in influenza A virus (IAV)-induced cytokine storm. O-GlcNAc transferase (OGT), a key enzyme for protein O-GlcNAcylation, mediated IAV-induced production. Upon investigating mechanisms driving event, determined that IAV induced OGT to bind interferon regulatory factor-5 (IRF5), leading O-GlcNAcylation IRF5 on serine-430. is required...
Present in more than one billion adults, hypertension is the most significant modifiable risk factor for mortality resulting from cardiovascular disease. Although its pathogenesis not yet fully understood, disruption of renin‑angiotensin system (RAS), consisting systemic and brain RAS, has been recognized as primary reasons several types hypertension. Therefore, acquiring sound knowledge basic science RAS underlying mechanisms signaling pathways associated with may facilitate discovery novel...
Sympathetic activity is enhanced in hypertension, which contributes to the pathogenesis of hypertension and progression organ damage. The cardiac sympathetic afferent reflex (CSAR) renovascular involved activation. present study was designed investigate whether angiotensin II (Ang II) Ang type 1 (AT1) receptors paraventricular nucleus (PVN) contribute CSAR outflow experimental hypertensive rats. Hypertension induced by two-kidney one-clip (2K1C) method. normotensive rats underwent sham...
Proliferation of vascular smooth muscle cells (VSMCs) greatly contributes to remodeling in hypertension. This study is determine the roles and mechanisms miR-135a-5p intervention attenuating VSMC proliferation spontaneously hypertensive rats (SHRs). MiR-135a-5p level was raised, while fibronectin type III domain-containing 5 (FNDC5) mRNA protein expressions were reduced VSMCs SHRs compared with those Wistar-Kyoto (WKYs). Enhanced inhibited by knockdown or inhibitor, but exacerbated mimic....
Estimate glucose disposal rate (eGDR), Chinese visceral adiposity index (CVAI), triglyceride-glucose (TyG), TyG-body mass (TyG-BMI), metabolic score for insulin resistance (METS-IR), and atherogenic of plasma (AIP) are considered surrogate indexes (IR). There is a lack studies comparing the predictive values different IR stroke risk among individuals with abnormal metabolism. This study aimed to investigate relationships between six in metabolism, evaluate their abilities risk. Data from...
Background: Transcatheter aortic valve replacement (TAVR) is currently the main approach for treating severe stenosis (AS), and preoperative echocardiography a necessary measure. In this research, we analyzed application value of transthoracic (TTE) transesophageal (TEE) in TAVR, aiming to provide more reliable reference opinions future clinical implementation TAVR patients with AS. Methods: 204 AS who were treated our hospital from January 2022 February 2024 selected as research subjects....
Background: Transthoracic echocardiography (TTE) and transesophageal (TEE) are two of the most commonly used echocardiographic protocols in clinical practice. In this study, we compared differences effects on hemodynamics, inflammatory stress response, pain mediators patients with severe aortic stenosis (AS). Methods: 204 AS who were treated Transcatheter valve replacement (TAVR) our hospital from January 2022 to February 2024 selected as research subjects. Among them, 109 received TTE (TTE...
Our previous studies have shown that angiotensin II and reactive oxygen species in the paraventricular nucleus (PVN) modulate cardiac sympathetic afferent reflex (CSAR). The present study was designed to demonstrate more conclusively PVN is an important component of central neurocircuitry CSAR. In anaesthetized Sprague-Dawley rats with sinoaortic denervation cervical vagotomy, renal nerve activity (RSNA) mean arterial pressure (MAP) were continuously recorded. CSAR evaluated by response RSNA...
Vascular oxidative stress and inflammation play a major role in vascular diseases. This study was aimed at determining the protective roles of fibronectin type III domain-containing 5 (FNDC5) angiotensin II- (Ang II-) induced underlying mechanisms. Wild-type (WT) FNDC5 -/- mice, primary mouse smooth muscle cells (VSMCs), rat aortic cell line (A7R5) were used present study. Subcutaneous infusion Ang II caused more serious hypertension, remodeling, stress, NLRP3 inflammasome activation, AMPK...
Erianin (Eri) is the extract of Dendrobium chrysotoxum Lindl. The NLRP3 inflammasome a multiprotein complex that plays key roles in wide variety chronic inflammation-driven human diseases. Nevertheless, little known about protection Eri against inflammasome-related In this study, we demonstrated inhibited activation vitro and vivo . Mechanistically, directly interacted with NLRP3, leading to inhibition assembly. associated Walker A motif NACHT domain suppressed ATPase activity. mouse models,...
With the proposed goal of “Carbon Neutrality”, photovoltaic energy is gradually gaining leading role in transformation. At present, crystalline silicon cells are still mainstream technology industry, but due to similarity defect characteristics and small scale defects, automatic detection (PV) by electroluminescence (EL) imaging a challenging task. In order better meet growing demand for high-quality cell products intelligent manufacturing use, ensure safe efficient operation power stations,...
Circulating Ang II activates an aldosterone-mineralocorticoid receptor (MR) - angiotensin (Ang II) type 1 (AT1R) pathway in the hypothalamus. To obtain insights into actual neuronal projections involved, adeno-associated virus carrying small interfering RNA against either AT1aR (AAV-AT1aR-siRNA) or MR (AAV-MR-siRNA) were infused paraventricular nucleus (PVN) Wistar rats. Intra-PVN infusion of AAV-AT1aR-siRNA AAV-MR-siRNA decreased AT1R expression PVN but not subfornical organ (SFO)...
Proliferation and oxidative stress of vascular smooth muscle cells (VSMCs) contribute to remodeling in hypertension several major diseases. B-cell lymphoma 6 (BCL6) functions as a transcriptional repressor. The present study is designed determine the roles BCL6 VSMC proliferation underlying mechanism. Angiotensin (Ang) II was used induce human VSMCs. Effects overexpression knockdown were, respectively, investigated Ang II-treated Therapeutical effects on remodeling, stress, were determined...
Hepatitis B virus X protein (HBx) critically contributes to the development of hepatocellular carcinoma (HCC). However, mechanisms by which HBx promotes HCC remain unclear. In present study, using a combination gene expression profiling and immunohistochemistry, we found higher levels SH2 domain–containing 5 (SH2D5) in liver tissue from HBV-associated (HBV-HCC) patients than adjacent nontumor tissues. Moreover, HBV infection elevated SH2D5 levels, observed that plays an important role...
Oxidative stress and the migration of vascular smooth muscle cells (VSMCs) are important for remodeling in a variety diseases. miR-31-5p promotes cell colorectal cancer but inhibits renal carcinoma. However, whether is involved oxidative VSMC remains unknown. This study shows crucial roles migration, as well underlying mechanisms. Experiments were carried out primary VSMCs from aortic media Wistar–Kyoto rats (WKY) spontaneously hypertensive (SHR), A7r5 line. was assessed by NADPH oxidase...
Intracerebroventricular infusion of a mineralocorticoid receptor (MR) or angiotensin II type 1 (AT1R) blocker in rats attenuates sympathetic hyperactivity and progressive left ventricular (LV) dysfunction post myocardial infarction (MI). The present study examined whether knockdown MRs AT1Rs specifically the paraventricular nucleus (PVN) contributes to these effects, compared cardiac effects with those systemic treatment β1-adrenergic metoprolol. PVN was infused adeno-associated virus...
Glucagon-like peptide-1 (GLP-1) and its analogs are widely used for diabetes treatment. The paraventricular nucleus (PVN) is crucial regulating cardiovascular activity. This study aims to determine the roles of GLP-1 receptors (GLP-1R) in PVN sympathetic outflow blood pressure. Experiments were carried out male normotensive rats spontaneously hypertensive (SHR). Renal nerve activity (RSNA) mean arterial pressure (MAP) recorded. GLP-1R expressions present PVN. microinjection agonist...