A5104683167- Glycosylation and Glycoproteins Research
- Ubiquitin and proteasome pathways
- Advanced Breast Cancer Therapies
- Chronic Lymphocytic Leukemia Research
- Galectins and Cancer Biology
- Proteoglycans and glycosaminoglycans research
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- Hedgehog Signaling Pathway Studies
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Chromatin Remodeling and Cancer
- Advancements in Transdermal Drug Delivery
- Breast Cancer Treatment Studies
- Immune Cell Function and Interaction
- interferon and immune responses
- Monoclonal and Polyclonal Antibodies Research
- Advanced Fluorescence Microscopy Techniques
- Tumors and Oncological Cases
George Washington University
2021-2024
Qilu Hospital of Shandong University
2024
Hubei University of Technology
2020
In this study, we demonstrated an essential function of the hexosamine biosynthesis pathway (HBP)-associated O-linked β-N-acetylglucosamine (O-GlcNAc) signaling in influenza A virus (IAV)-induced cytokine storm. O-GlcNAc transferase (OGT), a key enzyme for protein O-GlcNAcylation, mediated IAV-induced production. Upon investigating mechanisms driving event, determined that IAV induced OGT to bind interferon regulatory factor-5 (IRF5), leading O-GlcNAcylation IRF5 on serine-430. is required...
Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) play a pivotal role in cell cycle cancer development. Targeting CDK4/6 has demonstrated promising effects against breast cancer. However, resistance to inhibitors (CDK4/6i), such as palbociclib, remains substantial challenge clinical settings. Using high-throughput combinatorial drug screening genomic sequencing, we find that the microphthalmia-associated transcription factor (MITF) is activated via O-GlcNAcylation by O-GlcNAc transferase...
Abstract Glioblastoma multiforme (GBM) remains incurable despite multimodal treatments after surgical debulking. Almost all patients with GBM relapse within a narrow margin (2–3 cm) of the initial resected lesion due to unreachable residual cancerous cells. Here, completely biodegradable microneedle for cavity delivery glioblastoma‐associated macrophages (GAMs)‐activating immune nano‐stimulator that mitigates glioblastoma is reported. The tumor lesion‐directed biocompatible releases and...
Abstract The JAK2/STAT pathway is hyperactivated in many cancers, and such hyperactivation associated with a poor clinical prognosis drug resistance. mechanism regulating JAK2 activity complex. Although translocation of between nucleus cytoplasm an important regulatory mechanism, how regulated what the physiological function this remain largely unknown. Here, we found that protease SENP1 directly interacts deSUMOylates JAK2, deSUMOylation leads to its accumulation at cytoplasm, where...
Cyclin-dependent kinases 4 and 6 (CDK4/6) play a pivotal role in cell cycle cancer development. Targeting CDK4/6 has demonstrated promising effects against breast cancer. However, resistance to inhibitors (CDK4/6i), such as palbociclib, remains substantial challenge clinical settings. Using high-throughput combinatorial drug screening genomic sequencing, we found that the microphthalmia-associated transcription factor (MITF) is activated via O-GlcNAcylation by O-GlcNAc transferase (OGT)...