A5086311823- Service-Oriented Architecture and Web Services
- DNA Repair Mechanisms
- Wound Healing and Treatments
- Ocular Diseases and Behçet’s Syndrome
- MicroRNA in disease regulation
- Advanced Software Engineering Methodologies
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Systemic Lupus Erythematosus Research
- Advanced biosensing and bioanalysis techniques
- interferon and immune responses
- Microtubule and mitosis dynamics
- Asthma and respiratory diseases
- Business Process Modeling and Analysis
- Retinal Diseases and Treatments
- Stability and Control of Uncertain Systems
- T-cell and B-cell Immunology
- Ubiquitin and proteasome pathways
- Proteoglycans and glycosaminoglycans research
- Stability and Controllability of Differential Equations
- Protist diversity and phylogeny
- Synthesis and Biological Evaluation
- Mobile Agent-Based Network Management
Tianjin First Center Hospital
2023-2025
Tianjin Medical University
2023-2025
Anhui Jianzhu University
2025
Nankai University
2020-2025
Beijing University of Chinese Medicine
2022-2024
George Washington University
2018-2024
Beihang University
2008-2024
China Academy of Railway Sciences
2023-2024
Beth Israel Deaconess Medical Center
2022-2024
University of California, San Diego
2024
Abstract Th17 cells require IL-6 and TGFβ for lineage commitment IL-23 maintenance. Unexpectedly, naive IL-6−/− splenocytes stimulated with anti-CD3 produced normal amounts of IL-17 during the first 24 h culture. These rapid IL-6-independent producers were identified as predominantly DX5+ TCRβ+ NKT cells, a comparable response could be found using invariant NKT-specific ligand α-galactosylceramide. Human also IL-17. constitutively expressed IL-23R RORγt. Ligation either TCR or triggered...
Gellan gum is a naturally occurring polymer that can cross-link in the presence of divalent cations to form biocompatible hydrogels. However, physically cross-linked gellan hydrogels lose their stability under physiological conditions, thus restricting applications these vivo. To improve mechanical strength gels, we incorporated methacrylate into and chemically hydrogel through three polymerization methods: step growth thiol-ene photoclick chemistry, chain-growth via photopolymerization,...
Rheumatoid arthritis (RA) is an autoimmune disease with unknown etiology, occurring in approximately 1.0% of general population. More and more studies have suggested that long non-coding RNAs (lncRNAs) could play important roles various biological processes be associated the pathogenesis different kinds diseases including RA. Although a large number lncRNAs been found, our knowledge their function physiological/pathological significance still its infancy. In order to reveal functional...
Abstract Poly-(ADP-ribose) polymerase inhibitors (PARPi) selectively kill breast and ovarian cancers with defects in homologous recombination (HR) caused by BRCA1/2 mutations. There is also clinical evidence for the utility of PARPi without BRCA mutations, but underlying mechanism not clear. Here, we report that deubiquitylating enzyme USP15 affects cancer cell response to regulating HR. Mechanistically, recruited DNA double-strand breaks (DSBs) MDC1, which requires FHA domain MDC1...
Abstract Purpose NHHR, the ratio of non-high-density lipoprotein cholesterol to high-density cholesterol, is a novel lipid marker associated with risk heart diseases and various health conditions. However, there limited evidence regarding relationship between NHHR onset hypertension diseases. The aim this study was investigate association new-onset among Chinese middle-aged older general population. Methods This prospective cohort utilized data from nationally representative sample residents...
Thrombospondin (TSP)-1 has been reported to modulate T cell behavior both positively and negatively. We found that these opposing responses arise from interactions of TSP1 with two different receptors. The integrin α4β1 recognizes an LDVP sequence in the NH2-terminal domain was required for stimulation adhesion, chemotaxis, matrix metalloproteinase gene expression by TSP1. Recognition cells depended on activation state integrin, inhibited interaction activated its counter receptor vascular...
Cell surface proteoglycans on T cells contribute to retroviral infection, binding of chemokines and other proteins, are necessary for some cell responses the matricellular glycoprotein thrombospondin-1. The major expressed by primary Jurkat have an apparent M(r) > 200,000 modified with chondroitin sulfate heparan chains. Thrombospondin-1 bound in a heparin-inhibitable manner this proteoglycan soluble form released into medium. Based mass spectrometry, knockdown, immunochemical analyses,...
Abstract Background Premature ovarian insufficiency refers to the loss of function before 40 years age. The etiology is heterogeneous, and genetic factors account for 20–25% cases. However, how transform findings clinical molecular diagnose remains a challenge. To identify potential causative variations POI, next generation sequencing panel with 28 known genes POI was designed, large cohort 500 Chinese Han patients screened directly. Pathogenic evaluation identified variants phenotype...
Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) play a pivotal role in cell cycle cancer development. Targeting CDK4/6 has demonstrated promising effects against breast cancer. However, resistance to inhibitors (CDK4/6i), such as palbociclib, remains substantial challenge clinical settings. Using high-throughput combinatorial drug screening genomic sequencing, we find that the microphthalmia-associated transcription factor (MITF) is activated via O-GlcNAcylation by O-GlcNAc transferase...
CO2 transcritical power cycle (CTPC) systems have attracted considerable research focus in the fields of thermoelectric conversion and waste heat recovery. The regenerator is a key component affecting CTPC system's efficiency. To improve comprehensive performance regenerator, extensive has been conducted to optimize flow channel design. However, optimization traditional Z-channel printed circuit exchanger structure (ZPCHE) limited constant cross-sectional configurations along direction,...
Biological activities of the matrix glycoprotein thrombospondin-1 (TSP1) are cell type specific and depend on relative expression or activation several TSP1 receptors. Although engaging individual receptors in T lymphocytes can elicit costimulating signals, this study we show that intact inhibits TCR-mediated activation, assessed globally using cDNA microarrays. signaling suppressed genes induced Jurkat cells, including markers CD69, early growth response gene-1 (Egr-1), phosphatase...
Abstract In vivo blockade of the human IL-2R by mAb has been used for immunosuppression in transplantation, therapy leukemia, and autoimmune diseases. this study, we report that administration a humanized blocking Ab induced 4- to 20-fold expansion CD56bright regulatory NK cells uveitis patients over time. The from exhibited similar phenotype as those naturally occurring cells. Patients with active had significantly lower level compared normal donors (p < 0.01). addition, could...
Abstract Noninfectious uveitis is a predominantly T cell-mediated autoimmune, intraocular inflammatory disease. To characterize the gene expression profile from patients with noninfectious uveitis, PBMCs were isolated 50 clinically characterized syndrome. A pathway-specific cDNA microarray was used for profiling and real-time PCR array further confirmation. Sixty-seven inflammation- autoimmune-associated genes found differentially expressed in patients, 28 of those being validated by PCR....
Age-related macular degeneration remains the leading cause of irreversible blindness in United States and developed world. Intravitreal injections anti–vascular endothelial growth factor (VEGF) medications have become standard care for treatment wet form disease. Recent reports demonstrated an association with various immune factors. We aimed to investigate effect immunosuppressive therapy clinical course compared anti-VEGF plus one three systemic therapies versus alone recurrent choroidal...
We examined the regulation of α4β1 integrin function in melanoma cells and T by ligands CD47. A CD47 antibody (B6H12) that inhibited αvβ3-mediated adhesion induced CD47-binding peptides from thrombospondin-1 directly stimulated α4β1-mediated same to vascular cell molecule-1 N-terminal regions or thrombospondin-2. B6H12 also α4β1- as well α2β1- α5β1-mediated CD47-expressing but not CD47-deficient cells. co-purified a detergent-stable complex on affinity column. based C-terminal sequences...